从临床需求到脓毒症血液净化聚合物材料的进展综述
A review of progress from clinical needs to polymeric materials for sepsis blood purification.
摘要(中文译文)
脓毒症是由感染触发的危及生命的器官功能障碍综合征，以高发病率、高死亡率和不良预后为特征，已成为公共卫生和重症医学领域的重大挑战。脓毒症的临床管理受到制约，原因在于传统疗法无法有效清除致病介质，这使得血液净化成为一种重要的辅助策略。然而，血液净化材料的性能必须直接满足特定的临床需求，包括高吸附容量、快速动力学、选择性和生物相容性。本综述采用“从临床需求到材料解决方案”的框架。首先分析脓毒症血液净化的临床共识与争议，并总结血液净化材料的关键性能要求。随后，全面概述商业产品与实验室阶段新兴材料的设计原理、构效关系及临床性能，重点阐述高分子化学与工程如何应对临床挑战。此外，评估血液净化的优势与局限性，并讨论血液净化材料未来发展方向的前景。本综述旨在为临床实践和学术研究提供系统参考，推动脓毒症血液净化治疗的精准化和规范化应用。
Abstract
Sepsis is a life-threatening organ dysfunction syndrome triggered by infection, characterized by high morbidity, mortality, and poor prognosis, and has emerged as a major challenge in public health and critical care medicine. The clinical management of sepsis is hindered by the inability of conventional therapies to effectively remove pathogenic mediators, making blood purification an important adjunctive strategy. However, the performance of blood purification materials must directly address specific clinical requirements, including high adsorption capacity, rapid kinetics, selectivity, and biocompatibility. This review adopts a "from clinical needs to materials solutions" framework. The clinical consensus and controversies surrounding blood purification in sepsis are analyzed first, and the key performance requirements for blood purification materials are summarized. Then, it comprehensively outlines the design principles, structure-property relationships, and clinical performance of both commercial products and emerging laboratory-stage materials, with emphasis on how polymer chemistry and engineering address clinical challenges. Additionally, the benefits and limitations of blood purification are evaluated, and prospects for the future directions for the development of blood purification materials are discussed. This review aims to provide a systematic reference for clinical practice and academic research, and promote the precise and standardized application of blood purification therapy for sepsis.
如何引用
AMA
Long Chen, Yitong Wang, Tianyuan Hui, Sainan Li, Jianyi Liu, Zehao Niu, et al. A review of progress from clinical needs to polymeric materials for sepsis blood purification.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb01242f.
APA
Long Chen, Yitong Wang, Tianyuan Hui, Sainan Li, Jianyi Liu, Zehao Niu, et al (2026). A review of progress from clinical needs to polymeric materials for sepsis blood purification.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb01242f
GB/T 7714
Long Chen, Yitong Wang, Tianyuan Hui, Sainan Li, Jianyi Liu, Zehao Niu, et al. A review of progress from clinical needs to polymeric materials for sepsis blood purification.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb01242f.
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