针对溶骨性疾病的精确生物材料治疗策略
Precision biomaterial therapeutic strategies for osteolytic diseases.
摘要(中文译文)
溶骨性疾病是一类主要以进行性骨破坏和骨稳态失衡为特征的疾病，常见于骨髓炎、牙周炎、骨转移和骨质疏松症等病理状态。由于病理机制复杂及局部微环境异常，传统治疗策略在病灶部位的精准干预和长期疗效维持方面仍面临明显局限。近年来，生物材料的快速发展为溶骨性疾病的治疗开辟了新的研究途径；通过调控骨吸收与骨形成过程，有望实现对疾病进展的有效干预。本文围绕五类典型的溶骨性疾病，系统总结了以刺激响应型药物递送材料和骨量调控材料为代表的先进治疗策略。其中，刺激响应型材料能够响应局部微环境特征，实现治疗药物在病灶区域内的时空可控释放；骨量调控材料则通过抑制异常的破骨细胞活性并促进成骨过程来恢复骨稳态。此外，针对感染、肿瘤和代谢异常等多种病理病因，本文总结了代表性生物材料的设计策略和研究进展，同时比较分析了各类治疗系统在作用机制、优势与局限性方面的差异。总体而言，基于生物材料的治疗策略为溶骨性疾病的精准治疗提供了重要机遇，并在推动治疗模式从对症处理向病因干预转变方面展现出广阔前景。
Abstract
Osteolytic diseases are a group of conditions characterised primarily by progressive bone destruction and an imbalance in bone homeostasis; they are commonly observed in pathological conditions such as osteomyelitis, periodontitis, bone metastases and osteoporosis. Due to complex pathological mechanisms and abnormalities in the local microenvironment, traditional treatment strategies still face significant limitations in terms of precise intervention at the site of the lesion and the maintenance of long-term efficacy. In recent years, rapid advances in biomaterials have opened new avenues of research for the treatment of osteolytic diseases; by modulating the processes of bone resorption and formation, it is hoped that effective intervention in disease progression can be achieved. This review systematically summarises advanced therapeutic strategies, represented by stimulus-responsive drug delivery materials and bone mass-regulating materials, focusing on five typical categories of osteolytic diseases. Among these, stimulus-responsive materials can respond to the characteristics of the local microenvironment, enabling the spatiotemporally controlled release of therapeutic drugs within the lesion area; bone mass-regulating materials, meanwhile, restore bone homeostasis by inhibiting abnormal osteoclastic activity and promoting the osteogenic process. Furthermore, addressing various pathological aetiologies such as infection, tumours and metabolic abnormalities, this paper summarises the design strategies and research progress of representative biomaterials, whilst comparing and analysing the differences among various therapeutic systems in terms of their mechanisms of action, advantages and limitations. Overall, biomaterial-based therapeutic strategies offer significant opportunities for the precision treatment of osteolytic diseases and demonstrate broad prospects for driving a shift in treatment paradigms from symptomatic management towards aetiological intervention.
如何引用
AMA
Hanyue Xue, Yangbin Wang, Keyu Kong, Sonu Ng, Yang Li, Wenxuan Fan, et al. Precision biomaterial therapeutic strategies for osteolytic diseases.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00511j.
APA
Hanyue Xue, Yangbin Wang, Keyu Kong, Sonu Ng, Yang Li, Wenxuan Fan, et al (2026). Precision biomaterial therapeutic strategies for osteolytic diseases.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00511j
GB/T 7714
Hanyue Xue, Yangbin Wang, Keyu Kong, Sonu Ng, Yang Li, Wenxuan Fan, et al. Precision biomaterial therapeutic strategies for osteolytic diseases.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00511j.
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