用于治疗眼部疾病的超分子肽水凝胶：从组织替代到药物递送系统
Supramolecular peptide hydrogels for the treatment of ocular diseases: from tissue replacements to drug delivery systems.
摘要(中文译文)
超分子肽水凝胶（SPHs）是一类由肽自组装形成的独特动态三维网络，在眼科应用中已展现出用于眼组织替代和药物递送的强大潜力。一方面，通过肽的合理设计，可精确调控其力学和理化性质，以模拟天然眼组织。另一方面，SPHs固有的动态特性使其能够高效包载市售药物，并引入刺激响应性或靶向部分，从而促进眼屏障穿透并增强治疗效果。在本综述中，我们系统总结了SPHs在眼病治疗中应用的最新进展，重点聚焦其设计原则及两个关键应用方面：眼组织替代物（用于玻璃体和角膜修复）以及针对常见眼病的药物递送系统，包括干眼病、角膜新生血管、细菌性角膜炎、前葡萄膜炎、糖尿病视网膜病变和年龄相关性黄斑变性。这些发现凸显了SPHs作为下一代精准眼科治疗生物材料的前景。
Abstract
Supramolecular peptide hydrogels (SPHs), a unique class of dynamic three-dimensional networks formed by self-assembly of peptides, have demonstrated strong potential for ocular tissue replacement and drug delivery in ophthalmic applications. On the one hand, their mechanical and physiochemical properties can be precisely tailored rational design of peptides to emulate native ocular tissues. On the other hand, the intrinsic dynamic features of SPHs enable efficient encapsulation of commercial drugs and incorporation of stimuli-responsive or targeting moieties, which in turn facilitate ocular barrier penetration and enhance therapeutic efficacy. In this review, we systematically summarize recent advances of the use of SPHs in ocular disease treatment, focusing on their design principles and two key application aspects: ocular tissue substitutes (for vitreous and corneal repair) and drug delivery systems targeting prevalent ocular pathologies, including dry eye disease, corneal neovascularization, bacterial keratitis, anterior uveitis, diabetic retinopathy, and age-related macular degeneration. These findings highlight the promising potential of SPHs as next-generation biomaterials for precision ophthalmic therapy.
如何引用
AMA
Daowei Xia, Wenting Li, Jing Xie, Dongdong Zhou, Hao Su. Supramolecular peptide hydrogels for the treatment of ocular diseases: from tissue replacements to drug delivery systems.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00761a.
APA
Daowei Xia, Wenting Li, Jing Xie, Dongdong Zhou, Hao Su (2026). Supramolecular peptide hydrogels for the treatment of ocular diseases: from tissue replacements to drug delivery systems.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00761a
GB/T 7714
Daowei Xia, Wenting Li, Jing Xie, Dongdong Zhou, Hao Su. Supramolecular peptide hydrogels for the treatment of ocular diseases: from tissue replacements to drug delivery systems.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00761a.
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