用于感染伤口愈合的NIR增强型纳米酶催化剂的按需功能
On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.
摘要(中文译文)
具有内在类酶活性的纳米酶在从生物传感到治疗等多个领域展现出巨大潜力。然而，其发展仍受限于催化效率和稳定性不足等科学挑战。在此，我们提出一种创新的“纳米均匀分布”策略，通过将超小氧化铈纳米颗粒锚定在金纳米棒上，构建了金-氧化铈异质结构纳米催化剂。在近红外光照射下，该纳米催化剂不仅表现出优异的光热性能，还具有显著增强的酶模拟催化效率。此外，在无光照条件下，它仍保持强大的活性氧清除能力和良好的生物相容性。随后利用表皮感染伤口模型进行的评估表明，该纳米复合催化剂具有“全时段”治疗功能：在近红外照射下，金-氧化铈复合纳米催化剂通过光热和酶催化效应协同对抗细菌感染；在无近红外照射下，它能有效清除过量活性氧并减轻炎症反应。总之，本研究提出了一种“纳米均匀分布”策略，显著提高了纳米酶的催化性能，为纳米酶的结构设计及其生物医学应用提供了有价值的见解。
Abstract
Nanozymes with intrinsic enzyme-like activities have demonstrated considerable potential in diverse fields ranging from biosensing to therapeutics. However, their development remains compromised by scientific challenges such as insufficient catalytic efficiency and stability. Herein, we propose an innovative "nano-uniform distribution" strategy to engineer an Au-ceria heterostructure nanocatalyst by anchoring ultrasmall cerium oxide nanoparticles onto Au nanorods. Under near-infrared (NIR) light irradiation, this nanocatalyst exhibits not only excellent photothermal properties but also a significantly enhanced enzyme-mimetic catalytic efficiency. Moreover, in the absence of light, it retains robust reactive oxygen species (ROS) scavenging capability and good biocompatibility. Subsequent evaluation using an epidermal infected wound model demonstrates that the nanocomposite catalyst exhibits an "all-temporal" therapeutic functionality: with NIR irradiation, the Au-ceria composite nanocatalyst synergistically combats bacterial infection through photothermal and enzymatic catalytic effects; without NIR irradiation, it effectively clears excess ROS and mitigates inflammatory responses. In summary, this study presents a "nano-uniform distribution" strategy that markedly improves the catalytic performance of nanozymes, offering valuable insights for the structural design of nanozymes and their biomedical applications.
如何引用
AMA
Jintao He, Pengpeng Jia, Ying Huang, Pan Shi, Miao Tian, Yunhua Xu, et al. On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00640j.
APA
Jintao He, Pengpeng Jia, Ying Huang, Pan Shi, Miao Tian, Yunhua Xu, et al (2026). On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00640j
GB/T 7714
Jintao He, Pengpeng Jia, Ying Huang, Pan Shi, Miao Tian, Yunhua Xu, et al. On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00640j.
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