具有高适应性和生物利用度的肿瘤靶向半刚性金属有机聚合物骨架纳米颗粒
Tumor-targeting semi-rigid metal-organic-polymer framework nanoparticles with high adaptability and bioavailability.
摘要(中文译文)
在自然界中，大多数生物组织兼具特定的结构稳定性与功能适应性。这一独特优势有助于药物载体耐受各种复杂的微环境和生物膜。因此，我们将具有上临界溶解温度（UCST）的柔性热响应聚合物链接枝到刚性多孔金属有机框架中，构建了仿生铜基双重响应金属有机聚合物框架（MOPF）纳米颗粒，用于靶向抗肿瘤治疗。该MOPF纳米载体表现出显著的载药量（9.03%）和包封率（96.40%），以及高度的适应性和生物利用度。在类似于肿瘤微环境的高热（43 °C）和高谷胱甘肽（GSH）浓度（10 mM）双重刺激下，其累积药物释放量在24小时内迅速达到65.82%，同时发生结构解离。通过催化的类芬顿反应，从MOPF中暴露的铜离子被进一步诱导产生大量羟基自由基，进而消耗GSH，导致高细胞凋亡率（细胞存活率：4.70%）。这种半刚性MOPF微结构不仅实现了化疗、化学动力学疗法和铜毒性疗法的融合，还为多功能药物载体适应治疗过程提供了一种创新策略。
Abstract
In nature, most bio-tissues combine specific structural stability with functional adaptability. This unique virtue can help drug carriers endure various complicated microenvironments and biomembranes. So, we integrated flexible thermo-responsive polymer chains with upper critical solution temperature (UCST) into a rigid porous metal-organic framework to construct bioinspired copper-based dual-responsive metal-organic-polymer framework (MOPF) nanoparticles for targeted anti-tumor treatment. This MOPF nanocarrier exhibited significant drug-loading (9.03%) and encapsulation efficiency (96.40%), as well as high adaptivity and bioavailability. Under the dual stimulation of hyperthermia (43 °C) and high glutathione (GSH) concentration (10 mM) similar to a tumor microenvironment, its cumulative drug release rapidly reached 65.82% in 24 hours, along with simultaneous structural dissociation. By a catalyzed Fenton-like reaction, the copper ions exposed from MOPF were further induced to generate a large number of hydroxyl radicals and then exhaust GSH with high cell apoptosis (cell survival: 4.70%). Such semi-rigid MOPF microstructures not only realized the merging of chemotherapy, chemodynamic therapy, and copper toxicity therapy but also provided an innovative strategy to adapt a therapeutic process for a multifunctional drug carrier.
如何引用
AMA
Shuxuan Liu, Kaiteng Pang, Meili Sun, Jie Qiao, Hongjing He, Yao Wang, et al. Tumor-targeting semi-rigid metal-organic-polymer framework nanoparticles with high adaptability and bioavailability.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00472e.
APA
Shuxuan Liu, Kaiteng Pang, Meili Sun, Jie Qiao, Hongjing He, Yao Wang, et al (2026). Tumor-targeting semi-rigid metal-organic-polymer framework nanoparticles with high adaptability and bioavailability.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00472e
GB/T 7714
Shuxuan Liu, Kaiteng Pang, Meili Sun, Jie Qiao, Hongjing He, Yao Wang, et al. Tumor-targeting semi-rigid metal-organic-polymer framework nanoparticles with high adaptability and bioavailability.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00472e.
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