一种新型根管冲洗剂可实现单宁酸-银纳米涂层的快速形成，用于根管感染中的持续抗菌治疗
A novel root canal irrigant enabling rapid formation of a tannic acid-silver nanocoating for sustained antibacterial therapy in root canal infections.
摘要(中文译文)
持续根管内消毒有助于彻底清除残留的病原微生物并防止根管感染复发。现有的长时间消毒策略依赖于氢氧化钙或抗生素糊剂，然而这些药物需要后续彻底去除，从而延长了治疗周期并增加了操作复杂性。在此，我们报道了一种基于单宁酸（TA）溶液和硝酸银（AgNO₃）溶液的双组分冲洗系统，该系统可在≤3分钟内快速形成持久的抗菌涂层，且无需后续去除。该系统通过双腔注射器递送，借助酚羟基与银的配位及随后的还原反应，在根管壁上生成TA-Ag纳米涂层，通过银的持续释放实现长期消毒。抗菌实验表明，TA-Ag冲洗系统在3分钟处理后对生物膜的清除率超过99%，并能抑制牙本质上的细菌定植长达2周。此外，TA分子可通过酚羟基螯合体液中的钙离子，诱导钙结晶并促进根管壁再矿化。小鼠伤口感染模型证实，TA-Ag冲洗液能有效清除细菌、减轻炎症并加速组织愈合。牙髓干细胞实验和口腔黏膜接触试验验证了其生物相容性和安全性。总之，本研究提出了一种安全有效的根管冲洗系统，能够实现持续的根管内消毒和再矿化，在根管治疗及其他生物医学应用中展现出巨大前景。
Abstract
Continuous intracanal disinfection facilitates the complete elimination of residual pathogenic microorganisms and prevents the recurrence of root canal infections. Current prolonged disinfection strategies rely on calcium hydroxide or antibiotic pastes; however, these agents require thorough subsequent removal, which extends the treatment cycle and increases procedural complexity. Herein, we report a two-component irrigation system based on tannic acid (TA) solution and silver nitrate (AgNO) solution that rapidly forms a long-lasting antibacterial coating (≤3 min) without the need for subsequent removal. Delivered a dual-chamber syringe, this system generates a TA-Ag nanocoating on the root canal wall through phenolic hydroxyl-Ag coordination and subsequent reduction, enabling long-term disinfection through sustained Ag release. Antibacterial assays demonstrated that the TA-Ag irrigation system achieved over 99% eradication of biofilms after a 3-min treatment and maintained inhibition of bacterial colonization on dentin for up to 2 weeks. In addition, TA molecules can chelate calcium ions from body fluid phenolic hydroxyl groups, inducing calcium crystallization and promoting root canal wall remineralization. mouse wound infection models confirmed that the TA-Ag irrigant efficiently eliminates bacteria, attenuates inflammation, and accelerates tissue healing. Dental pulp stem cell experiments and oral mucosal contact tests verified its biocompatibility and safety. Collectively, this study presents a safe and effective root canal irrigation system capable of sustained intracanal disinfection and remineralization, showing great promise in root canal therapy and also other biomedical applications.
如何引用
AMA
Xinzhi Tan, Chan He, Xingyu Hu, Fangjun Huo, Peini Lin, Pu Li, et al. A novel root canal irrigant enabling rapid formation of a tannic acid-silver nanocoating for sustained antibacterial therapy in root canal infections.. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00185h.
APA
Xinzhi Tan, Chan He, Xingyu Hu, Fangjun Huo, Peini Lin, Pu Li, et al (2026). A novel root canal irrigant enabling rapid formation of a tannic acid-silver nanocoating for sustained antibacterial therapy in root canal infections.. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00185h
GB/T 7714
Xinzhi Tan, Chan He, Xingyu Hu, Fangjun Huo, Peini Lin, Pu Li, et al. A novel root canal irrigant enabling rapid formation of a tannic acid-silver nanocoating for sustained antibacterial therapy in root canal infections.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00185h.
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