工程化碳基量子点：用于传染病治疗和诊断的下一代纳米药物
Engineered carbon-based quantum dots: a next-generation nanomedicine for the therapy and diagnosis of infectious diseases.
摘要(中文译文)
传染病仍是全球重大公共卫生问题，尽管抗生素和化学疗法已取得进展。针对新发及多重耐药微生物，开发新型治疗和诊断制剂的需求尚未得到满足。为克服这些问题，碳基量子点（QDs），即碳量子点（CQDs）和石墨烯量子点（GQDs），因其多样且独特的性质（如化学惰性、低毒性、生物相容性和光稳定性）而可成为一种替代途径。通过掺杂、功能化、表面钝化或与抗菌物质结合等方式整合多种部分而制备的工程化量子点（EQDs），在传染病管理中具有广泛的生物学应用。本综述旨在全面讨论天然量子点（CQDs和GQDs）及EQDs针对多种传染病致病病原体（即细菌、病毒、真菌和寄生虫）的药理学机制和检测策略的最新进展。其主要作用机制涉及细胞壁/膜破坏、复制和转录抑制、过量活性氧（ROS）生成、免疫应答通路激活以及与抗菌剂的协同相互作用。此外，EQDs整合了多种检测策略，包括光学、核酸、免疫、侧流分析和电化学检测，强调了其作为敏感探针用于快速监测生物和环境样本中病原体的潜在用途。最后，本综述讨论了不断变化的监管要求、潜在毒性以及临床转化中的挑战。本综述必将有助于推动利用天然QDs/EQDs开发新的可负担抗菌药物和诊断制剂的研究活动。
Abstract
Infectious diseases are a major global health issue despite the development of antibiotics and chemotherapy. There is an unmet need for the development of novel therapeutic and diagnostic agents to combat emerging and multi-drug-resistant microorganisms. To overcome these issues, carbon-based quantum dots (QDs), , carbon quantum dots (CQDs) and graphene quantum dots (GQDs), can be an alternative approach due to their diverse and distinct properties, such as chemical inertness, low toxicity, biocompatibility, and photostability. Engineered QDs (EQDs) prepared by integrating various moieties through doping, functionalization, surface passivation, or combination with antimicrobial substances have vast biological applications in the management of infectious diseases. The current review aims to comprehensively discuss the recent progress on pharmacological mechanisms and detection strategies of native QDs (CQDs and GQDs), and EQDs against a wide range of infectious disease-causing pathogens, namely, bacteria, viruses, fungi, and parasites. The major mechanisms of their action involve cell wall/membrane disruption, replication and transcription inhibition, excessive ROS generation, immune response pathway activation, and synergistic interactions with antimicrobial agents. In addition, EQDs integrated diverse detection strategies, including optical, nucleic acid, immune, lateral flow assay, electrochemistry, emphasizing their potential use as sensitive probes for the rapid monitoring of pathogens in biological and environmental samples. Finally, the evolving scenarios of regulatory requirements, potential toxicity, and challenges in their clinical translation are addressed in this review. The current review will certainly be useful in advancing research activities for developing new affordable antimicrobial drugs and diagnostic agents using native QDs/EQDs.
如何引用
AMA
Kallol Roy, Esha Roy, Nibedita Saikia, Pankaj Barman, Binoy K Saikia, Rituraj Konwar. Engineered carbon-based quantum dots: a next-generation nanomedicine for the therapy and diagnosis of infectious diseases.. Journal of materials chemistry. B. 2026; doi:10.1039/d5tb02755a.
APA
Kallol Roy, Esha Roy, Nibedita Saikia, Pankaj Barman, Binoy K Saikia, Rituraj Konwar (2026). Engineered carbon-based quantum dots: a next-generation nanomedicine for the therapy and diagnosis of infectious diseases.. Journal of materials chemistry. B. https://doi.org/10.1039/d5tb02755a
GB/T 7714
Kallol Roy, Esha Roy, Nibedita Saikia, Pankaj Barman, Binoy K Saikia, Rituraj Konwar. Engineered carbon-based quantum dots: a next-generation nanomedicine for the therapy and diagnosis of infectious diseases.[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d5tb02755a.
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