交联聚（N-丙烯酰基甘氨酸）纳米颗粒对2型糖尿病并发症的保护作用：体内研究
{"_":"Protective effects of cross-linked poly(-acryloyl glycine) nanoparticles in type 2 diabetes-induced complications: study.","i":["N","in vivo"]}
摘要(中文译文)
慢性高血糖诱导的活性氧（ROS）和全身性炎症可导致周围神经、心脏神经以及自主神经系统的损伤。这种损伤进展缓慢，在较长时间内逐渐发生。这些对机体重要器官的累积性损伤可导致心脏骤停等致命后果或患者极度不适，并可引发周围感染和神经病理性疼痛。针对进展性糖尿病周围神经病变（DPN）和糖尿病心脏神经病变（DCN），目前可用的治疗选择有限，仅限于血糖管理。在此背景下，本研究开发了具有生物相容性的聚丙烯酰甘氨酸纳米颗粒（pNAG NPs），其粒径为100-350 nm，具有多孔结构，有助于减轻炎症和ROS，进而保护神经、肝脏、胰腺和心脏组织。在MIN 6细胞上的研究显示了pNAG纳米颗粒的促增殖效应和细胞相容性。这些纳米颗粒的治疗效果通过高脂饮食诱导的糖尿病大鼠模型进行了验证。围绕重要器官进行了代谢和功能分析，并测定了胰岛素敏感性、葡萄糖和精氨酸耐量。评估了心电图（ECG）和神经传导速度（NCV），以及若干重要炎症标志物和ROS指示酶（过氧化物酶）的作用，证实了pNAG NPs的治疗反应。本研究进一步证明了pNAG NPs在2型糖尿病管理中的潜在作用，包括减轻炎症、改善代谢功能以及心脏和神经保护效应。结果表明，我们的pNAG NPs及该治疗策略可减轻糖尿病引起的主要并发症，并可能成为一种替代治疗选择。
Abstract
Chronic hyperglycemia-induced ROS and systemic inflammation can lead to damage to peripheral and cardiac nerves as well as the autonomic nervous system. This damage progresses slowly and occurs over a long period of time. This collective damage to vital organs of the body leads to fatal effects such as cardiac arrest or extreme discomfort to patients, and can cause peripheral infections and neuropathic pain. There are limited therapeutic options available for progressive diabetic peripheral neuropathy (DPN) and diabetic cardiac neuropathy (DCN) limited to blood glucose management. Along this line, in this work we have developed biocompatible poly(-acryloyl glycine) nanoparticles (pNAG NPs) with a size of 100-350 nm and with a porous structure, which help in reducing inflammation and ROS, and subsequently protect neuronal, liver, pancreas, and cardiac tissues. An study on MIN 6 cells shows the proliferative effects and cytocompatibility of the pNAG nanoparticles. The therapeutic efficiency of these nanoparticles was validated through a high-fat diet-induced diabetes rat model. Metabolic and functional analyses were performed considering essential organs, and determined the insulin sensitivity, glucose and arginine tolerance. ECG and NCV, along with the role of a few essential inflammatory markers and ROS-indicating enzymes (peroxidase), were assessed and proved the therapeutic response of the pNAG NPs. This work further demonstrates the potential impact of pNAG NPs for the management of type 2 diabetes with reduction of inflammation, improvement of metabolic function, and cardio- and neuroprotective effects. The results show that our pNAG NPs and the therapeutic approach can mitigate major diabetes-induced complications and could be an alternate therapeutic option.
如何引用
AMA
Gurmeet Singh, Taniya Das, Kirti Wasnik, Desh Deepak Yadav, Divya Pareek, Pradip Paik. {"_":"Protective effects of cross-linked poly(-acryloyl glycine) nanoparticles in type 2 diabetes-induced complications: study.","i":["N","in vivo"]}. Journal of materials chemistry. B. 2026; doi:10.1039/d6tb00902f.
APA
Gurmeet Singh, Taniya Das, Kirti Wasnik, Desh Deepak Yadav, Divya Pareek, Pradip Paik (2026). {"_":"Protective effects of cross-linked poly(-acryloyl glycine) nanoparticles in type 2 diabetes-induced complications: study.","i":["N","in vivo"]}. Journal of materials chemistry. B. https://doi.org/10.1039/d6tb00902f
GB/T 7714
Gurmeet Singh, Taniya Das, Kirti Wasnik, Desh Deepak Yadav, Divya Pareek, Pradip Paik. {"_":"Protective effects of cross-linked poly(-acryloyl glycine) nanoparticles in type 2 diabetes-induced complications: study.","i":["N","in vivo"]}[J]. Journal of materials chemistry. B, 2026 doi:10.1039/d6tb00902f.
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