合成生物学 synthetic biology - PubMed 文献(第 4 页)
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合成生物学 的 PubMed 搜索结果(第 4 页)
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The Potential for Convergence between Synthetic Biology and Bioelectronics. 合成生物学与生物电子学融合的潜力
The fields of synthetic biology, which focuses on genetic and cellular substrates, and bioelectronics, which focuses on interfacing electronics with biology, may appear to have little in common on the surface. However, we contend that there is potential for convergence between the two fields based on shared and complementary design principles from each field. We provide examples where this convergence is beginning to take place in the engineered measurement and control of cell populations, individual cells, and membrane transport. We propose that as the convergence spreads, bioelectronics will enable real-time sensing and control of synthetic biological processes through integration with conventional electronics. The increased capabilities resulting from this convergence may broaden the scope and deepen the impact of both synthetic biology and bioelectronics.
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Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials. 探索合成生物学在工程化活体材料中的应用与前景
At the intersection of synthetic biology and materials science, engineered living materials (ELMs) exhibit unprecedented potential. Possessing unique "living" attributes, ELMs represent a significant paradigm shift in material design, showcasing self-organization, self-repair, adaptability, and evolvability, surpassing conventional synthetic materials. This review focuses on reviewing the applications of ELMs derived from bacteria, fungi, and plants in environmental remediation, eco-friendly architecture, and sustainable energy. The review provides a comprehensive overview of the latest research progress and emerging design strategies for ELMs in various application fields from the perspectives of synthetic biology and materials science. In addition, the review provides valuable references for the design of novel ELMs, extending the potential applications of future ELMs. The investigation into the synergistic application possibilities amongst different species of ELMs offers beneficial reference information for researchers and practitioners in this field. Finally, future trends and development challenges of synthetic biology for ELMs in the coming years are discussed in detail.
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Control engineering and synthetic biology: working in synergy for the analysis and control of microbial systems. 控制工程与合成生物学：协同作用于微生物系统的分析与控制
The implementation of novel functionalities in living cells is a key aspect of synthetic biology. In the last decade, the field of synthetic biology has made progress working in synergy with control engineering, whose solid framework has provided concepts and tools to analyse biological systems and guide their design. In this review, we briefly highlight recent work focused on the application of control theoretical concepts and tools for the analysis and design of synthetic biology systems in microbial cells.
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An integrative database and its application for plant synthetic biology research. 综合数据库及其在植物合成生物学研究中的应用
Plant synthetic biology research requires diverse bioparts that facilitate the redesign and construction of new-to-nature biological devices or systems in plants. Limited by few well-characterized bioparts for plant chassis, the development of plant synthetic biology lags behind that of its microbial counterpart. Here, we constructed a web-based Plant Synthetic BioDatabase (PSBD), which currently categorizes 1677 catalytic bioparts and 384 regulatory elements and provides information on 309 species and 850 chemicals. Online bioinformatics tools including local BLAST, chem similarity, phylogenetic analysis, and visual strength are provided to assist with the rational design of genetic circuits for manipulation of gene expression in planta. We demonstrated the utility of the PSBD by functionally characterizing taxadiene synthase 2 and its quantitative regulation in tobacco leaves. More powerful synthetic devices were then assembled to amplify the transcriptional signals, enabling enhanced expression of flavivirus non-structure 1 proteins in plants. The PSBD is expected to be an integrative and user-centered platform that provides a one-stop service for diverse applications in plant synthetic biology research.
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Applications and limitations of regulatory RNA elements in synthetic biology and biotechnology. 调控RNA元件在合成生物学和生物技术中的应用与局限
Synthetic biology requires the design and implementation of novel enzymes, genetic circuits or even entire cells, which can be controlled by the user. RNA-based regulatory elements have many important functional properties in this regard, such as their modular nature and their ability to respond to specific external stimuli. These properties have led to the widespread exploration of their use as gene regulation devices in synthetic biology. In this review, we focus on two major types of RNA elements: riboswitches and RNA thermometers (RNATs). We describe their general structure and function, before discussing their potential uses in synthetic biology (e.g. in the production of biofuels and biodegradable plastics). We also discuss their limitations, and novel strategies to implement RNA-based regulatory devices in biotechnological applications. We close with a description of some common model organisms used in synthetic biology, with a focus on the current applications and limitations of RNA-based regulation.
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Filamentous fungal synthetic biology: Current applications and ongoing developments. 丝状真菌合成生物学：当前应用与持续发展
Filamentous fungi have played an undeniable role in the biosphere for hundreds of millions of years and, for humans, have increasingly been developed as sources of food, medicine and other resources; their uses growing to include materials science and bioremediation. As these developments have gained pace, a variety of disparate fields are making new advances and turning to synthetic biology to increase their potential. As genetic sequencing and computing technologies widen our knowledge of the different species of fungi, synthetic biology enables us to harness and expand their unique traits. These developments are discussed in the context of these existing and emerging applications of engineering and synthetic biology, so that they might be more widely understood, thus promoting the standardisation of language and innovation. Certain challenges and research gaps within the investigated research fields are also highlighted, as are various opportunities and connections found during the exploration of these fields, and the impact of developing technologies including 3D printing and cell-free systems.
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Microbes as Biosensors. 微生物作为生物传感器
The ability to detect disease early and deliver precision therapy would be transformative for the treatment of human illnesses. To achieve these goals, biosensors that can pinpoint when and where diseases emerge are needed. Rapid advances in synthetic biology are enabling us to exploit the information-processing abilities of living cells to diagnose disease and then treat it in a controlled fashion. For example, living sensors could be designed to precisely sense disease biomarkers, such as by-products of inflammation, and to respond by delivering targeted therapeutics in situ. Here, we provide an overview of ongoing efforts in microbial biosensor design, highlight translational opportunities, and discuss challenges for enabling sense-and-respond precision medicines.
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Synthetic Biology Approaches to Enzymology in Food and Agriculture Systems. 食品和农业系统酶学的合成生物学方法
Global food insecurity remains a challenge, with 2.3 billion people worldwide experiencing food insecurity. Applications of synthetic biology offer a promising way to address this crisis through innovative and sustainable enzyme-mediated solutions. This review explores enzymology with food and agriculture systems and how recent advances are aided by synthetic biology. Focusing on how enzymes can be engineered for the greatest good to promote food safety, improved production, and coproduct valorization, we survey state-of-the-art advances in enzyme engineering to achieve these goals, providing a critical review on how technology from other industries could be adapted to food and agriculture. Key areas discussed include biocatalysis of food ingredients, synthetic biology for yield improvements, and computation design of enzymatic pathways for more resource-efficient food processing. This review concludes with a discussion of current limitations, regulations, and future directions for integrating synthetic biology into global food systems.
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Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances. 非常规酵母中的合成生物学与分子遗传学：当前工具与未来进展
Coupling the tools of synthetic biology with traditional molecular genetic techniques can enable the rapid prototyping and optimization of yeast strains. While the era of yeast synthetic biology began in the well-characterized model organism Saccharomyces cerevisiae, it is swiftly expanding to include non-conventional yeast production systems such as Hansenula polymorpha, Kluyveromyces lactis, Pichia pastoris, and Yarrowia lipolytica. These yeasts already have roles in the manufacture of vaccines, therapeutic proteins, food additives, and biorenewable chemicals, but recent synthetic biology advances have the potential to greatly expand and diversify their impact on biotechnology. In this review, we summarize the development of synthetic biological tools (including promoters and terminators) and enabling molecular genetics approaches that have been applied in these four promising alternative biomanufacturing platforms. An emphasis is placed on synthetic parts and genome editing tools. Finally, we discuss examples of synthetic tools developed in other organisms that can be adapted or optimized for these hosts in the near future.
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Synthetic biology tools for environmental protection. 用于环境保护的合成生物学工具
Synthetic biology transforms the way we perceive biological systems. Emerging technologies in this field affect many disciplines of science and engineering. Traditionally, synthetic biology approaches were commonly aimed at developing cost-effective microbial cell factories to produce chemicals from renewable sources. Based on this, the immediate beneficial impact of synthetic biology on the environment came from reducing our oil dependency. However, synthetic biology is starting to play a more direct role in environmental protection. Toxic chemicals released by industries and agriculture endanger the environment, disrupting ecosystem balance and biodiversity loss. This review highlights synthetic biology approaches that can help environmental protection by providing remediation systems capable of sensing and responding to specific pollutants. Remediation strategies based on genetically engineered microbes and plants are discussed. Further, an overview of computational approaches that facilitate the design and application of synthetic biology tools in environmental protection is presented.