合成生物学 synthetic biology - PubMed 文献(第 2 页)
PubMed 共收录约 81,794 篇相关文献，本站只列出其中相关度最高的前 50 篇（共 5 页）；要看全部结果、按影响因子 / 分区 / 年份筛选，请前往完整搜索。
本页是「合成生物学（synthetic biology）」PubMed 检索结果的第 2 页，列出第 11–20 篇相关文献；主题介绍见第 1 页。
合成生物学 的 PubMed 搜索结果(第 2 页)
-
Transforming drug development with synthetic biology and AI. 以合成生物学和人工智能变革药物开发
The COVID-19 pandemic has thrust RNA as a platform for drug development into the spotlight. However, identifying promising drug candidates is challenging. With advances in synthetic biology and artificial intelligence (AI) models, we can overcome this hurdle, transforming drug development and ushering in a new era in the pharmaceutical industry.
-
Synthetic biology-powered microbial co-culture strategy and application of bacterial cellulose-based composite materials. 合成生物学驱动的微生物共培养策略及细菌纤维素基复合材料的应用
Bacterial cellulose (BC) is a carbohydrate polymer that is widely produced by diverse bacteria with unique structural features and properties. BC has a high water-retention capacity, appealing mechanical properties, and higher purity compared to plant cellulose. Due to these attractive properties, BC has been exploited in many applications, including biomedical treatment, textiles, architecture, and environmental engineering. Recently, taking advantage of synthetic biology concepts and techniques, the integration of genetically engineered microorganisms and BC produces composite materials with intriguing characteristics, for example, responsiveness to stimuli and capability to regenerate. These synthetic biology-inspired BC-based composite materials greatly extend the scopes of applications of BC. In this review, we discuss the construction and application of BC-based composite materials with an emphasis on those produced by genetically engineered microorganisms and by microbial co-culture approaches. We highlight the advantages of the synthetic biology-inspired fabrication strategy of BC-based composites and consider the challenges that need to be addressed by future work.
-
Use and dual use of synthetic biology. 合成生物学的使用和双重使用
A brief history of the field shows that the impression of novelty we have today when we talk about synthetic biology is merely the sign of a rapid loss of memory of the events surrounding its creation. The dangers of misuse were identified even before the first experiments, but this has not led to a shared awareness. Building a cell ab initio involves combining a machine (called a chassis by specialists in the field) and a program in the form of synthetic DNA. Only the latter—the program—is the subject of the vast majority of work in the field, and it is there that the risks of misuse appear. Combined with knowledge of the genomic sequence of pathogens, DNA synthesis makes it possible to reconstitute dangerous organisms or even to develop new ways of propagating malicious software. Finally, the lack of thought given to the risk of accidents when laboratories develop gain-of-function experiments that increase the virulence of a pathogen makes a world where this type of experiments is developed particularly dangerous.
-
Synthetic biology-driven microbial production of folates: Advances and perspectives. 合成生物学驱动的微生物生产叶酸：进展和前景
With the development and application of synthetic biology, significant progress has been made in the production of folate by microbial fermentation using cell factories, especially for using generally regarded as safe (GRAS) microorganism as production host. In this review, the physiological functions and applications of folates were firstly discussed. Second, the current advances of folate-producing GRAS strains development were summarized. Third, the applications of synthetic biology-based metabolic regulatory tools in GRAS strains were introduced, and the progress in the application of these tools for folate production were summarized. Finally, the challenges to folates efficient production and corresponding emerging strategies to overcome them by synthetic biology were discussed, including the construction of biosensors using tetrahydrofolate riboswitches to regulate metabolic pathways, adaptive evolution to overcome the flux limitations of the folate pathway. The combination of new strategies and tools of synthetic biology is expected to further improve the efficiency of microbial folate synthesis.
-
Synthetic biology for Taxol biosynthesis and sustainable production. 用于紫杉醇生物合成和可持续生产的合成生物学
Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.
-
Tuning specificity and topology of lectins through synthetic biology. 通过合成生物学调控凝集素的特异性和拓扑结构
Lectins are non-immunoglobulin and non-catalytic glycan binding proteins that are able to decipher the structure and function of complex glycans. They are widely used as biomarkers for following alteration of glycosylation state in many diseases and have application in therapeutics. Controlling and extending lectin specificity and topology is the key for obtaining better tools. Furthermore, lectins and other glycan binding proteins can be combined with additional domains, providing novel functionalities. We provide a view on the current strategy with a focus on synthetic biology approaches yielding to novel specificity, but other novel architectures with novel application in biotechnology or therapy.
-
Plant synthetic biology could drive a revolution in biofuels and medicine. 植物合成生物学可能推动生物燃料和医学领域的革命
The plant synthetic biology field has exploded in the last five years, in part driven by techniques such as CRISPR and cheap DNA synthesis. This review summarizes the current state of research in plant synthetic biology, and how it is being applied to two topics: renewable fuels and chemicals, and medicine.
-
RNA and RNP as Building Blocks for Nanotechnology and Synthetic Biology. RNA和RNP作为纳米技术和合成生物学的构建模块
Recent technologies that aimed to elucidate cellular function have revealed essential roles for RNA molecules in living systems. Our knowledge concerning functional and structural information of naturally occurring RNA and RNA-protein (RNP) complexes is increasing rapidly. RNA and RNP interaction motifs are structural units that function as building blocks to constitute variety of complex structures. RNA-central synthetic biology and nanotechnology are constructive approaches that employ the accumulated information and build synthetic RNA (RNP)-based circuits and nanostructures. Here, we describe how to design and construct synthetic RNA (RNP)-based devices and structures at the nanometer-scale for biological and future therapeutic applications. RNA/RNP nanostructures can also be utilized as the molecular scaffold to control the localization or interactions of target molecule(s). Moreover, RNA motifs recognized by RNA-binding proteins can be applied to make protein-responsive translational "switches" that can turn gene expression "on" or "off" depending on the intracellular environment. This "synthetic RNA and RNP world" will expand tools for nanotechnology and synthetic biology. In addition, these reconstructive approaches would lead to a greater understanding of building principle in naturally occurring RNA/RNP molecules and systems.
-
Co-evolution of physical and social sciences in synthetic biology. 合成生物学中物理科学和社会科学的共同进化
Emerging technologies research often covers various perspectives in disciplines and research areas ranging from hard sciences, engineering, policymaking, and sociology. However, the interrelationship between these different disciplinary domains, particularly the physical and social sciences, often occurs many years after a technology has matured and moved towards commercialization. Synthetic biology may serve an exception to this idea, where, since 2000, the physical and the social sciences communities have increasingly framed their research in response to various perspectives in biological engineering, risk assessment needs, governance challenges, and the social implications that the technology may incur. This paper reviews a broad collection of synthetic biology literature from 2000-2016, and demonstrates how the co-development of physical and social science communities has grown throughout synthetic biology's earliest stages of development. Further, this paper indicates that future co-development of synthetic biology scholarship will assist with significant challenges of the technology's risk assessment, governance, and public engagement needs, where an interdisciplinary approach is necessary to foster sustainable, risk-informed, and societally beneficial technological advances moving forward.
-
"Toehold Switches; a foothold for Synthetic Biology". “立足点开关：合成生物学的立足点”
Toehold switches are de novo designed riboregulators that contain two RNA components interacting through linear-linear RNA interactions, regulating the gene expression. These are highly versatile, exhibit excellent orthogonality, wide dynamic range, and are highly programmable, so can be used for various applications in synthetic biology. In this review, we summarized and discussed the design characteristics and benefits of toehold switch riboregulators over conventional riboregulators. We also discussed applications and recent advancements of toehold switch riboregulators in various fields like gene editing, DNA nanotechnology, translational repression, and diagnostics (detection of microRNAs and some pathogens). Toehold switches, therefore, furnished advancement in synthetic biology applications in various fields with their prominent features.