合成生物学 synthetic biology - PubMed 文献(第 5 页)
PubMed 共收录约 81,794 篇相关文献，本站只列出其中相关度最高的前 50 篇（共 5 页）；要看全部结果、按影响因子 / 分区 / 年份筛选，请前往完整搜索。
本页是「合成生物学（synthetic biology）」PubMed 检索结果的第 5 页，列出第 41–50 篇相关文献；主题介绍见第 1 页。
合成生物学 的 PubMed 搜索结果(第 5 页)
-
Synthetic biology for sustainable food colourant production: Innovations and opportunities. 用于可持续食用色素生产的合成生物学：创新与机遇
Natural healthy food colourants are increasingly demanded to replace synthetic ones which are linked to public health concerns. Although nature provides a rich palette of colours, producing food colourants from food crops or specific agricultural products can exacerbate food security issues and environmental challenges, such as deforestation driven by the expansion of farmland. Synthetic biology offers promising solutions to address the supply limitations of natural food colourants through developing colour-enriched plant varieties and particularly, high-yield microbial cell factories for production through precision fermentation. For the efficient translation of microbial fermentation solutions, it is important to integrate interdisciplinary synthetic/engineering biology research platforms, ranging from AI-assisted biological design to streamlined strain engineering workflows, and systems biology facilities, to address production challenges for scaling up. Bridging the lab-to-market gap through innovative economics and legality mechanism can accelerates the industrialisation of sustainable natural food colourants.
-
Synthetic biology and personalized medicine. 合成生物学与个性化医疗
Synthetic biology, application of synthetic chemistry to biology, is a broad term that covers the engineering of biological systems with structures and functions not found in nature to process information, manipulate chemicals, produce energy, maintain cell environment and enhance human health. Synthetic biology devices contribute not only to improve our understanding of disease mechanisms, but also provide novel diagnostic tools. Methods based on synthetic biology enable the design of novel strategies for the treatment of cancer, immune diseases metabolic disorders and infectious diseases as well as the production of cheap drugs. The potential of synthetic genome, using an expanded genetic code that is designed for specific drug synthesis as well as delivery and activation of the drug in vivo by a pathological signal, was already pointed out during a lecture delivered at Kuwait University in 2005. Of two approaches to synthetic biology, top-down and bottom-up, the latter is more relevant to the development of personalized medicines as it provides more flexibility in constructing a partially synthetic cell from basic building blocks for a desired task.
-
Synthetic Biology Approaches to Posttranslational Regulation in Plants. 植物翻译后调控的合成生物学方法
To date synthetic biology approaches involving creation of functional genetic modules are used in a wide range of organisms. In plants, such approaches are used both for research in the field of functional genomics and to increase the yield of agricultural crops. Of particular interest are methods that allow controlling genetic apparatus of the plants at post-translational level, which allow reducing non-targeted effects from interference with the plant genome. This review discusses recent advances in the plant synthetic biology for regulation of the plant metabolism at posttranslational level and highlights their future directions.
-
Directed evolution: an evolving and enabling synthetic biology tool. 定向进化：一种进化和使能的合成生物学工具
Synthetic biology, with its goal of designing biological entities for wide-ranging purposes, remains a field of intensive research interest. However, the vast complexity of biological systems has heretofore rendered rational design prohibitively difficult. As a result, directed evolution remains a valuable tool for synthetic biology, enabling the identification of desired functionalities from large libraries of variants. This review highlights the most recent advances in the use of directed evolution in synthetic biology, focusing on new techniques and applications at the pathway and genome scale.
-
Opportunities for artificial intelligence and synthetic biology in designing living drug delivery systems. 人工智能与合成生物学在设计活体药物递送系统中的机遇
Advances in artificial intelligence (AI) and synthetic biology are transforming biological research and biotechnology. These fields are for the first time enabling the design and development of human and bacterial cells that can serve as "living" drug delivery vehicles that perform sustained release of therapeutic cargo with spatiotemporal control. In recent years, human and bacterial cells have been engineered to deliver peptides, proteins, and biologics for treating a wide range of human diseases using synthetic biology approaches. To engineer effective living drug delivery systems, detailed knowledge is required about how to design receptors that can specifically sense the tissues targeted for drug delivery, signaling networks that can process signals from these receptors, and gene circuits that can control therapeutic cargo production and release. However, elucidating such receptors, signal processing and gene regulatory elements, and gene circuit compositions by traditional design-build-test-learn approaches is difficult and low throughput. Here we review how advances in AI and synthetic biology are meeting these challenges. We describe examples of how human cells and bacteria are engineered to become living drug delivery vehicles. We discuss how AI and synthetic biology approaches are being applied to discover the sequence-to-function design principles for engineering synthetic receptors, signaling proteins, and gene regulatory elements and the composition-to-function design principles for engineering synthetic gene circuits. We share an outlook on opportunities for AI and synthetic biology to synergize for creating next-generation living drug delivery systems.
-
Synthetic biology for therapeutic applications. 合成生物学的治疗应用
Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug discovery and production, as well as vaccine development and treatment of infectious diseases, cancer, and metabolic disorders.
-
Synthetic Biology to Improve the Production of Lipases and Esterases (Review). 合成生物学改善脂肪酶和酯酶的生产（综述）
Synthetic biology is an emergent field of research whose aim is to make biology an engineering discipline, thus permitting to design, control, and standardize biological processes. Synthetic biology is therefore expected to boost the development of biotechnological processes such as protein production and enzyme engineering, which can be significantly relevant for lipases and esterases.
-
Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering. 合成生物学与调控网络：代谢系统生物学与控制工程的交汇
Metabolic pathways can be engineered to maximize the synthesis of various products of interest. With the advent of computational systems biology, this endeavour is usually carried out through in silico theoretical studies with the aim to guide and complement further in vitro and in vivo experimental efforts. Clearly, what counts is the result in vivo, not only in terms of maximal productivity but also robustness against environmental perturbations. Engineering an organism towards an increased production flux, however, often compromises that robustness. In this contribution, we review and investigate how various analytical approaches used in metabolic engineering and synthetic biology are related to concepts developed by systems and control engineering. While trade-offs between production optimality and cellular robustness have already been studied diagnostically and statically, the dynamics also matter. Integration of the dynamic design aspects of control engineering with the more diagnostic aspects of metabolic, hierarchical control and regulation analysis is leading to the new, conceptual and operational framework required for the design of robust and productive dynamic pathways.
-
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals. 合成生物学与代谢工程对精细化学品工业生产的影响
Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.
-
Systems-synthetic biology in understanding the complexities and simple devices in immunology. 系统合成生物学在理解免疫学复杂性与简单器件中的应用
Systems and synthetic biology in the coming era has the ability to manipulate, stimulate and engineer cells to counteract the pathogenic immune response. The inherent biological complexities associated with the creation of a device allow capitalizing the biotechnological resources either by simply administering a recombinant cytokine or just reprogramming the immune cells. The strategy outlined, adopted and discussed may mark the beginning with promising therapeutics based on the principles of synthetic immunology.