CURRENT OPINION IN MICROBIOLOGY微生物学新见
CURRENT OPINION IN MICROBIOLOGY(英文缩写 CURR OPIN MICROBIOL),ISSN 1369-5274,eISSN 1879-0364,中文译名:微生物学新见 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 7.584 | Q1 |
| 2022 | 5.400 | Q1 |
| 2023 | 5.900 | Q1 |
| 2024 | 7.500 | Q1 |
| 2025 | 8.000 | Q1 |
CURRENT OPINION IN MICROBIOLOGY 最新收录文献
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1. Structural diversity and functional versatility in Gram-positive S-layers.
PMID:日期:2026-10-01Surface layers (S-layers) are highly ordered, paracrystalline protein lattices that form the outermost envelope of many bacteria and archaea. Although widespread, their functions and structural organisation are only recently being elucidated at molecular resolution. This review addresses S-layer structure and function in Gram-positive bacteria, with emphasis on emerging insights into lattice-forming self-assembly and the mechanisms by which S-layers attach to the cell wall. Recent work highlights the role of Gram-positive S-layers as exoskeletons that provide organisation and mechanical stabilisation of the cell envelope, and discusses their involvement in host interactions and stress tolerance. Although crystallinity is central for S-layer function, these lattices must also incorporate intrinsic plasticity to accommodate cell curvature and permit cell growth and division. S-layers and associated proteins are increasingly thought to act as active organisers of the cell envelope, and can undergo shedding or remodelling in response to changing environmental conditions.
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2. Recent advances in lactic acid bacteria-derived extracellular vesicles.
PMID:日期:2026-10-01Lactic acid bacteria (LAB) are globally recognized for their essential roles in food fermentation and impact on human health. Recent evidence identifies bacterial extracellular vesicles (EVs) as unique functional entities, serving as key mediators in microbe-host interactions. LAB-EV biogenesis is primarily driven by mechanisms that compromise cell-wall integrity, including prophage-encoded holin-endolysin systems and autolysin activity. EVs as nano-sized particles exert diverse beneficial effects by inhibiting pathogens, shaping microbiota composition, reinforcing the intestinal epithelial barrier, and modulating host immunity. Their ability to cross biological barriers and reach distal organs also implies systemic impacts. Consequently, LAB-EVs are emerging as a versatile platform for next-generation postbiotics and delivery systems, capable of protecting and transporting bioactive compounds. The interpretation of the effects conveyed by LAB-EVs requires critical considerations regarding mechanistic depth and cargo heterogeneity. A so-far overlooked factor is the influence of bacteriophage elements, which can influence both biogenesis pathways and host immune signatures. To successfully transition toward industrial and clinical applications, research must shift from observational studies to rigorous mechanistic evaluations and standardized production strategies, such as the use of prophage-cured strains or the development of artificial EV-mimics. This review synthesizes recent advances in LAB-EV biology and outlines the considerations necessary to harness these nano-couriers as valuable tools in modern biomedicine and food science.
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3. Community metabolism in dynamic redox landscapes.
PMID:日期:2026-10-01Microbial communities are fundamentally shaped by the diverse metabolic processes through which microbes extract energy from the chemical and light-driven potential gradients in their environment. Thus, predicting microbial community dynamics requires a quantitative framework grounded in bioenergetics and accounting for the key factors influencing metabolite concentrations in microbes' local environment. Here, we present a perspective based on three tightly coupled factors governing microbial community metabolism: (i) the thermodynamics of redox reactions, that is, the redox tower, as a universal constraint on energy yield and reaction feasibility; (ii) external environmental and host-driven factors that set the availability of key metabolites that can act as electron donors and acceptors; and (iii) intracommunity cellular responses that alter metabolic outputs and feedback with local conditions. We emphasise that all three factors have to be integrated and considering any one without the others will only provide limited insights into community metabolisms. This integrative view needs to be incorporated into tightly coupled experiments and modelling to enable a mechanistic understanding of microbial community metabolism across environments.
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4. Cooperative anaerobic catabolism of chlorinated organic compounds: implications for sustainable bioremediation.
PMID:日期:2026-10-01Biodegradation research historically followed a reductionist approach focused on axenic (pure) cultures capable of catabolizing the specific contaminant(s) of interest. While this approach has substantially advanced our understanding of the microbiology, physiology, biochemistry, and genetics of contaminant degradation under laboratory conditions, it does not capture the complexity of natural and engineered environments. During in situ bioremediation, microbiomes are exposed to mixtures of contaminants, and microbial interactions profoundly influence contaminant transformation and fate. In anoxic environments, degradation of chlorinated compounds is often sustained by metabolic cooperation among taxonomically and physiologically distinct microorganisms. Through the exchange of metabolites such as hydrogen, formate, acetate, and other nutrients, microbial populations establish interdependent networks that overcome thermodynamic and physiological constraints, enabling self-sustaining systems of contaminant transformations that would be inefficient or impossible with individual organisms. We highlight examples of microbial interactions that underpin anaerobic catabolism of chlorinated contaminants, including systems resulting in self-sustained anaerobic bioremediation.
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5. Control of foreign DNA: emerging roles of xenogeneic silencers.
PMID:日期:2026-10-01Bacteria continuously acquire foreign DNA through horizontal gene transfer, yet its successful integration depends on regulatory mechanisms that balance genome protection with evolutionary innovation. Xenogeneic silencers are central to this process: they preferentially bind AT-rich DNA, a common feature of many horizontally acquired genetic elements, and repress its transcription. Recent studies, however, reveal a much broader regulatory repertoire. Beyond transcriptional repression, these proteins contribute to chromosome organization by forming higher-order nucleoprotein complexes and phase-separated condensates that shape bacterial nucleoid architecture. Furthermore, they play roles in regulating bacteriophage infection cycles, including mechanisms by which phages hijack host silencing activities for their own benefit. Their extensive regulatory reach, spanning virulence genes, biofilm formation, specialized metabolite production, and mobile genetic elements (MGEs), underscores their central role in connecting environmental signals, including fluctuations in the second messenger c-di-GMP, with gene expression, and genome organization. The diversification of xenogeneic silencers across bacterial chromosomes, plasmids, phages, and other MGEs highlights their evolutionary significance. Together, these recent findings position xenogeneic silencers as dynamic regulatory modules that shape the fate of foreign DNA across the horizontal gene transfer network.
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6. Interactions between fungi, algae, and bacteria: multispecies engineered living materials leverage function and structure.
PMID:日期:2026-10-01The need for materials that have a limited impact on the environment has led to the development of engineered living materials (ELMs), which integrate living organisms and material applications to generate functional matter. Filamentous fungi offer a promising scaffold to design ELMs, which can be produced from the bottom up, but the possibilities for introducing dynamic functionalities are limited. To solve this, multispecies ELMs can be designed, using bacteria and algae to introduce biological functions in the material. The amenability of bacteria for synthetic biology offers a suitable platform to develop novel functions, while algae can endow the material with photosynthetic properties. Due to the preexisting natural interactions between these organisms and fungi, such as lichens and fungal highways, the establishment of a consortium-based bottom-up ELM becomes feasible. In this review, we summarize the natural mutualistic interactions between fungi, algae, and bacteria and how they can be harnessed for the design and implementation of engineered living materials, using filamentous fungi as their structural backbone. Furthermore, we review the role of such interactions in industrial processes, where they have been engineered for wastewater treatment and biotechnological production. Lastly, we discuss the current challenges of engineered living materials, the advantages of consortia-based solutions, and their future perspectives.
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7. Organ-specific phenotypes of Candida albicans: implications for immunity and pathogenesis.
PMID:日期:2026-10-01Organ-specific immune responses are shaped by tissue microenvironments, which instruct and regulate the behaviour of tissue-resident macrophages and lymphocytes. During infection, microbes are also influenced by tissue-specific environmental signals, which may influence host-microbe interactions and infection outcome. The pathogenic fungus Candida albicans undergoes significant adaptation within the host, associated with major genetic and phenotypic changes as a result of stress responses. These underlie the ability of this yeast to evade host immune responses and establish infection. Recent evidence has pointed to C. albicans phenotypic diversity directly influencing the host microenvironment and therefore localised immune responses. In this review, we discuss organ-specific mechanisms of antifungal defence and fungal tissue-specific phenotypes and stress responses during invasive infection. We focus on C. albicans, the best studied fungal infection in multiple organs, while highlighting lessons learned from other fungal pathogens to signal important future directions for the field.
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8. Fructophilic lactic acid bacteria as a window into multi-scale convergent evolution.
PMID:日期:2026-10-01Fructophilic lactic acid bacteria (FLAB) are a group of lactic acid bacteria with unique growth characteristics, that is, poor growth on glucose. Their growth is enhanced in the presence of fructose or external electron acceptors. These organisms inhabit fructose-rich environments such as flowers, fruits, and pollinating insects, particularly honey bees. Apilactobacillus spp. and Fructobacillus spp. are representatives of FLAB, although they belong to phylogenetically distant clades. These organisms commonly possess markedly small genomes with a low number of coding DNA sequences. Furthermore, their genomes are characterized by a markedly reduced number of genes involved in carbohydrate transport and metabolism. Genome reduction in FLAB reflects convergent adaptation to fructose-rich environments rather than general genome streamlining. The two distinct FLAB genera, Fructobacillus and Apilactobacillus, independently lost more than 100 genes in statistically similar orders. In contrast, genes involved in carbohydrate and amino acid metabolism exhibited reversed orders of loss between the two genera. Furthermore, FLAB genomes lack an intact bifunctional alcohol/aldehyde dehydrogenase gene (adhE), which causes their poor growth on glucose. A comparative genomic study suggested the evolutionary process underlying adhE gene decay during adaptation to the fructose-rich environments, including pollinating insects. In conclusion, FLAB represent a unique example of habitat-driven convergent reductive evolution that can be investigated across multiple biological scales - from individual genes to whole genomes - in the diverse LAB group with a wide range of habitats, and partially share the fructophilic evolution with eukaryotic yeasts found in fructose-rich habitats.
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9. Understanding metabolic interactions between bacteria and fungi for cross-kingdom consortia applications.
PMID:日期:2026-10-01Bacterial-fungal interactions represent fundamental ecological associations that shape microbial community structure across diverse environments. While traditionally framed through the lens of antagonism, bacteria and fungi engage in sophisticated metabolic dialogs extending far beyond simple warfare. Both primary and specialized metabolites function as context-dependent signals, nutrient resources, and modulators of cellular processes that fundamentally influence the physiology, development, and evolutionary trajectory of both fungi and bacteria. Primary metabolites mediate mutualistic relationships through cross-feeding and syntrophy, while specialized metabolites, including volatile organic compounds, lipopeptides, and phenazines, modulate fungal physiology at sub-inhibitory concentrations, reprogramming metabolic networks and triggering adaptive responses without causing cell death. At the molecular level, bacterial metabolites regulate fungal gene expression through transcriptional reprogramming, with consequences that extend to long-term evolutionary adaptation. The complexity of Bacillus-Trichoderma interactions exemplifies how these principles translate into ecological outcomes, exhibiting context-dependent transitions from competition to synergism that enhance biocontrol efficacy, plant growth promotion, and organic matter turnover. Recognizing the multifunctional nature of microbial metabolites beyond direct toxicity opens new avenues for rationally engineering cross-kingdom consortia with targeted agricultural and biotechnological applications.
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10. Microbial growth control: integrating protein abundance and activity.
10. 微生物生长控制：整合蛋白质丰度和活性PMID:日期:2026-10-01Understanding the governing principles of microbial growth control is central to fundamental microbiology, biotechnology, and systems biology. Recent quantitative studies have highlighted the pivotal role of proteome allocation in microbial growth control. Rather than simply maximizing growth, microbial cells dynamically adjust their resource allocation strategies to balance multiple physiological traits due to the fundamental constraint of trade-offs. Moreover, beyond resource allocation, which largely involves 'abundance control', recent studies have revealed another critical regulatory layer of microbial growth - 'activity control', such as modulations of ribosomal elongation rates, metabolic enzyme efficiency, and the fraction of actively translating ribosomes. Integrating these quantitative principles is expected to advance a comprehensive understanding of how distinct microbial physio-types emerge across diverse ecological niches and to further guide the rational design of synthetic biology.