靶向细菌群体感应：群体感应抑制剂与创新抗菌策略在提升食品安全及应对抗生素耐药性中的见解
Targeting Bacterial Quorum Sensing: Insights into Quorum Sensing Inhibitors and Innovative Antimicrobial Strategies for Enhancing Food Safety and Combating Antibiotic Resistance.
摘要(中文译文)
抗生素耐药性的传播以及抗生素耐药表型多样性的不断增加，对食品安全和公共卫生构成了日益严重的威胁。食源性细菌利用群体感应（QS）调控毒力表达和生物膜形成，从而增强致病性和耐药性。因此，靶向QS被认为是控制细菌的一种有前景的策略。群体感应抑制剂（QSIs）在应对细菌耐药性方面极具前景，因为它们不依赖于直接杀灭细菌，而是通过破坏细菌的群体行为来减弱其在食品中的腐败效应。本综述聚焦于具有QSI活性的天然和合成化合物，阐述其作用机制及作为抗菌剂的潜力。此外，本综述提出了创新的抗菌策略，包括基于纳米技术的递送系统、与噬菌体联用、CRISPR-Cas技术以及与现有QSIs协同的多靶点方法。这些整合策略旨在克服现有挑战，为控制细菌污染和感染提供新方法，同时具有广阔的应用前景。
Abstract
Antibiotic resistance transmission and the increasing diversity of antibiotic resistance phenotypes pose growing threats to food safety and public health. Foodborne bacteria employ quorum sensing (QS) to regulate virulence expression and biofilm formation, enhancing pathogenicity and drug resistance. Therefore, targeting QS is regarded as a promising strategy to control bacteria. Quorum sensing inhibitors (QSIs) are highly promising for addressing bacterial resistance, as they do not rely on the direct killing of bacteria but rather on attenuation of bacterial spoilage effects in food by disrupting their group behavior. This review focuses on natural and synthetic compounds with QSI activity, elaborating their mechanisms and potential as antimicrobial agents. Additionally, the review proposes innovative antimicrobial strategies, including nanotechnology-based delivery systems, combination with phage, CRISPR-Cas technology, and multitargeted approaches cooperated with existing QSIs. These integrated strategies are designed to overcome challenges, providing novel methodologies for controlling bacterial contamination and infections while holding broad application prospects.
如何引用
AMA
Huirong Yang, Lulin Zhu, Jianying Zhi, Qingping Zhong. Targeting Bacterial Quorum Sensing: Insights into Quorum Sensing Inhibitors and Innovative Antimicrobial Strategies for Enhancing Food Safety and Combating Antibiotic Resistance.. Journal of agricultural and food chemistry. 2026; doi:10.1021/acs.jafc.5c17992.
APA
Huirong Yang, Lulin Zhu, Jianying Zhi, Qingping Zhong (2026). Targeting Bacterial Quorum Sensing: Insights into Quorum Sensing Inhibitors and Innovative Antimicrobial Strategies for Enhancing Food Safety and Combating Antibiotic Resistance.. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.5c17992
GB/T 7714
Huirong Yang, Lulin Zhu, Jianying Zhi, Qingping Zhong. Targeting Bacterial Quorum Sensing: Insights into Quorum Sensing Inhibitors and Innovative Antimicrobial Strategies for Enhancing Food Safety and Combating Antibiotic Resistance.[J]. Journal of agricultural and food chemistry, 2026 doi:10.1021/acs.jafc.5c17992.
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