膳食花青素：加工、药代动力学与新型包封/递送系统
Dietary Anthocyanins: Processing, Pharmacokinetics and Novel Encapsulation/Delivery Systems.
摘要(中文译文)
花青素（ACNs）是水溶性类黄酮色素，广泛分布于水果、蔬菜和谷物中，并与多种健康益处相关。其在功能食品中的应用受到限制，原因在于化学稳定性差以及生物利用度低且多变，后者由加工过程中pH依赖的结构互变和胃肠道内广泛的首过代谢所致。现有综述往往分别讨论生物活性或递送技术，而未阐明结构脆弱性如何转化为应指导递送设计的药代动力学约束。在此，我们提出一个将结构脆弱性、药代动力学局限性和递送设计相联系的综合框架。对新兴包封平台在稳定性、胃肠道滞留、释放行为和功能性能方面的影响进行了批判性评价。此外还讨论了安全性和监管方面的考量。未来研究应优先采用药代动力学指导和刺激响应性策略，以优化ACNs及其代谢物的时空归趋和功能性暴露特征。本综述可为基于ACNs的功能食品配方开发提供实践指导。
Abstract
Anthocyanins (ACNs) are water-soluble flavonoid pigments widely distributed in fruits, vegetables, and grains and associated with diverse health benefits. Their application in functional foods is limited by poor chemical stability and low, variable bioavailability caused by pH-dependent structural interconversion during processing and extensive presystemic metabolism in the gastrointestinal tract. Existing reviews often address bioactivity or delivery technologies separately, without clarifying how structural vulnerability translates into pharmacokinetic constraints that should guide delivery design. Here, we propose an integrative framework linking structural vulnerability, pharmacokinetic limitations, and delivery design. Emerging encapsulation platforms are critically evaluated for their effects on stability, gastrointestinal retention, release behavior, and functional performance. Safety and regulatory considerations are also discussed. Future research should prioritize pharmacokinetics-guided and stimuli-responsive strategies to optimize the spatiotemporal fate and functional exposure profile of ACNs and their metabolites. This review may provide practical guidance for the development of ACNs-based functional food formulations.
如何引用
AMA
Dandan Ma, Yong Cheng, Mengli Geng, Zhaojun Wang, Qiuming Chen, Maomao Zeng, et al. Dietary Anthocyanins: Processing, Pharmacokinetics and Novel Encapsulation/Delivery Systems.. Journal of agricultural and food chemistry. 2026; doi:10.1021/acs.jafc.5c17315.
APA
Dandan Ma, Yong Cheng, Mengli Geng, Zhaojun Wang, Qiuming Chen, Maomao Zeng, et al (2026). Dietary Anthocyanins: Processing, Pharmacokinetics and Novel Encapsulation/Delivery Systems.. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.5c17315
GB/T 7714
Dandan Ma, Yong Cheng, Mengli Geng, Zhaojun Wang, Qiuming Chen, Maomao Zeng, et al. Dietary Anthocyanins: Processing, Pharmacokinetics and Novel Encapsulation/Delivery Systems.[J]. Journal of agricultural and food chemistry, 2026 doi:10.1021/acs.jafc.5c17315.
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