{"_":"通过激活SF-1介导的类固醇激素生物合成增强睾酮生成来改善少弱精子症。","i":["冬虫夏草"]}
{"_":"Cultured Ameliorates Oligoasthenozoospermia by Enhancing Testosterone Production via Activation of SF-1-mediated Steroid Hormone Biosynthesis.","i":["Cordyceps Sinensis"]}
摘要(中文译文)
培养的（CCS）可改善少弱精子症（OAS）患者的精子质量，但其机制尚不清楚。本研究采用环磷酰胺（CTX）诱导的OAS小鼠模型，评估CCS对激素分泌、血睾屏障（BTB）完整性、睾丸氧化应激及生精细胞凋亡的影响，并进一步检测类固醇生成因子-1（SF-1）介导的类固醇激素生物合成。结果表明，CCS可升高血清激素水平、增加BTB相关蛋白表达并抑制生精细胞凋亡。此外，CCS上调了睾丸中类固醇生成酶及SF-1的蛋白表达。在体外实验中，CCS提取物可增强CTX损伤的TM3细胞的睾酮生成及类固醇生成酶表达，同时伴随SF-1的上调。此外，敲低SF-1可逆转CCS提取物对睾酮生成的作用。综上所述，CCS主要通过激活SF-1介导的类固醇激素生物合成来增强睾酮生成，从而改善OAS。睾酮水平升高有助于维持BTB完整性并抑制睾丸细胞凋亡。
Abstract
Cultured (CCS) improves sperm quality in patients with oligoasthenozoospermia (OAS), but its mechanisms remain unclear. A cyclophosphamide (CTX)-induced OAS mice model was employed to evaluate the effects of CCS on hormone secretion, blood-testis barrier (BTB) integrity, testicular oxidative stress, and spermatogenic cell apoptosis. The steroidogenic factor-1 (SF-1)-mediated steroid hormone biosynthesis was further examined. Our results demonstrated that CCS elevated serum hormone levels, increased BTB-related protein expression, and inhibited spermatogenic cell apoptosis. Furthermore, CCS upregulated the protein expression of steroidogenic enzymes and SF-1 in testes. In vitro, CCS extract enhanced testosterone production and steroidogenic enzyme expression in CTX-injured TM3 cells, concomitant with the upregulation of SF-1. Moreover, SF-1 knockdown reversed the effect of CCS extract on testosterone production. In conclusion, CCS improves OAS by enhancing testosterone production primarily via activation of SF-1-mediated steroid hormone biosynthesis. The increased testosterone contributes to maintaining BTB integrity and inhibiting testicular cell apoptosis.
如何引用
AMA
Boning Huang, Jingjing Wang, Siqi Xie, Zhengming Qian, Baoqin Lin. {"_":"Cultured Ameliorates Oligoasthenozoospermia by Enhancing Testosterone Production via Activation of SF-1-mediated Steroid Hormone Biosynthesis.","i":["Cordyceps Sinensis"]}. Journal of agricultural and food chemistry. 2026; doi:10.1021/acs.jafc.6c00772.
APA
Boning Huang, Jingjing Wang, Siqi Xie, Zhengming Qian, Baoqin Lin (2026). {"_":"Cultured Ameliorates Oligoasthenozoospermia by Enhancing Testosterone Production via Activation of SF-1-mediated Steroid Hormone Biosynthesis.","i":["Cordyceps Sinensis"]}. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.6c00772
GB/T 7714
Boning Huang, Jingjing Wang, Siqi Xie, Zhengming Qian, Baoqin Lin. {"_":"Cultured Ameliorates Oligoasthenozoospermia by Enhancing Testosterone Production via Activation of SF-1-mediated Steroid Hormone Biosynthesis.","i":["Cordyceps Sinensis"]}[J]. Journal of agricultural and food chemistry, 2026 doi:10.1021/acs.jafc.6c00772.
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