Nrf2/HO-1失调参与微塑料诱导的肠肝轴损伤机制和虾青素的保护作用
Nrf2/HO-1 Dysregulation is Involved in the Microplastic-Induced Gut-Liver Axis Damage Mechanism and the Protective Effect of Astaxanthin.
摘要(中文译文)
作为全球消费量最大的肉类产品之一，鸡肉中的微塑料（MPs）残留可能通过食物链进入人体。因此，本研究旨在探讨MPs暴露对鸡健康的不良影响以及虾青素（AST）的解毒机制。我们发现，MPs显著损害肝功能，诱导以肝细胞铁死亡、炎症、脂质紊乱和纤维化为特征的损伤。这种肝脏损伤与MPs引起的肠道菌群失调和肠道屏障破坏有关。AST通过激活Nrf2/HO-1信号通路并减轻肝脏氧化应激和铁死亡，发挥肝脏保护作用。同时，AST改善了肠道菌群组成和肠道屏障完整性，从而可能减少肠源性炎症负担。综上所述，这些研究结果表明，AST通过直接的肝脏作用和间接调节肠-肝轴来发挥肝脏保护作用。
Abstract
As one of the most consumed meat products globally, microplastics (MPs) residues in chickens may enter the human body through the food chain. Therefore, this study aimed to investigate the adverse effects of MPs exposure on chicken health and the detoxification mechanisms of astaxanthin (AST). We found that MPs significantly impaired liver function, inducing injury characterized by hepatocyte ferroptosis, inflammation, lipid disorder, and fibrosis. This hepatic damage was linked to MPs-induced gut microbiota dysbiosis and disruption of the intestinal barrier. AST exerted hepatoprotective effects by activating the Nrf2/HO-1 signaling pathway and attenuating hepatic oxidative stress and ferroptosis. In parallel, AST improved gut microbiota composition and intestinal barrier integrity, thereby potentially reducing gut-derived inflammatory burden. Together, these findings suggest that AST confers liver protection through both direct hepatic actions and indirect modulation of the gut-liver axis.
如何引用
AMA
Xiaoyan Guo, Zongsheng Qiu, Jingjing Qi, Yongti Liu, Baolian Yang, Chengwei Wei, et al. Nrf2/HO-1 Dysregulation is Involved in the Microplastic-Induced Gut-Liver Axis Damage Mechanism and the Protective Effect of Astaxanthin.. Journal of agricultural and food chemistry. 2026; doi:10.1021/acs.jafc.5c13915.
APA
Xiaoyan Guo, Zongsheng Qiu, Jingjing Qi, Yongti Liu, Baolian Yang, Chengwei Wei, et al (2026). Nrf2/HO-1 Dysregulation is Involved in the Microplastic-Induced Gut-Liver Axis Damage Mechanism and the Protective Effect of Astaxanthin.. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.5c13915
GB/T 7714
Xiaoyan Guo, Zongsheng Qiu, Jingjing Qi, Yongti Liu, Baolian Yang, Chengwei Wei, et al. Nrf2/HO-1 Dysregulation is Involved in the Microplastic-Induced Gut-Liver Axis Damage Mechanism and the Protective Effect of Astaxanthin.[J]. Journal of agricultural and food chemistry, 2026 doi:10.1021/acs.jafc.5c13915.
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