CURRENT OPINION IN CHEMICAL BIOLOGY化学生物学新见
CURRENT OPINION IN CHEMICAL BIOLOGY(英文缩写 CURR OPIN CHEM BIOL),ISSN 1367-5931,eISSN 1879-0402,中文译名:化学生物学新见 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 8.972 | Q1 |
| 2022 | 7.800 | Q1 |
| 2023 | 6.900 | Q1 |
| 2024 | 6.100 | Q1 |
| 2025 | 7.200 | Q1 |
CURRENT OPINION IN CHEMICAL BIOLOGY 最新收录文献
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1. Metalloadaptor and metallochaperone proteins reveal new chemical principles of biological metal homeostasis.
PMID:日期:2026-10-01Transition metals are essential nutrients that serve as metabolic cofactors and signaling agents in every cell type across all kingdoms of life. Owing to their relatively low abundance and high chemical reactivity, living organisms have evolved dedicated biochemical pathways to ensure active acquisition and targeted delivery of transition metals to their proper locations across biological length scales spanning tissues to cells to proteins, thus promoting beneficial physiology and avoiding detrimental pathology. Here we summarize recent advances in the discovery of copper metalloadaptor and zinc metallochaperone proteins that reveal new foundational chemical principles of biological metal homeostasis.
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2. Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans.
PMID:日期:2026-10-01Proteoglycans (PGs) are intricate macromolecules decorated with linear polysulfated glycosaminoglycans (GAGs) that play critical roles in orchestrating a wide range of physiological and pathological events. Advances in the utilization of recombinant enzymes and biosynthetic pathways have expedited the production of defined and homogeneous GAGs, helping overcome traditional barriers of chemical synthesis. Furthermore, the synthesis of GAG chains has been increasingly integrated with other critical structural elements, most notably the core proteins. Robust synthetic methodologies toward well-defined GAGs and entire PG structures are critical because there is a lack of comprehensive structure-function data that addresses the PG architecture as a unified glycoconjugate. The construction of homogeneous PG is a formidable and rapidly evolving frontier in chemical biology, and the latest developments in this arena are summarized in this review.
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3. Design of programmable molecular interfaces for synthetic biology and therapeutic applications.
PMID:日期:2026-10-01De novo protein design is reshaping how synthetic biology specifies and controls molecular function. Recent advances in generative modeling, sequence design and structure prediction enable molecular interactions to be created from scratch, reducing reliance on natural solutions and extensive experimental screening. These approaches support the design of compact, stable binding proteins, programmable interaction modules, and higher-order assemblies with defined geometry and regulatory behavior. As a result, de novo proteins are increasingly used to modulate signaling pathways, direct molecular targeting, and organize functional architectures across diverse biological contexts. Although challenges remain in predicting behavior in complex environments and balancing multiple design objectives, continued methodological progress is establishing de novo scaffolds as versatile, composable elements for the next-generation of synthetic biology.
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4. Recent discovery of new enzymes in plant natural product biosynthesis.
PMID:日期:2026-10-01Plants are a vast reservoir of natural products with diverse structural scaffolds, making them an invaluable source for discovering novel enzymes that catalyze unique and evolutionarily specialized metabolic transformations in biosynthetic pathways. Rapid advances in genomics, metabolomics, protein structure prediction, and heterologous pathway reconstruction have enabled the identification of numerous cryptic biosynthetic enzymes responsible for key scaffold-forming and tailoring reactions in metabolism. Particularly notable are the discoveries of plant-derived enzymes that catalyze challenging chemical transformations, including oxidative carbon-carbon bond rearrangements, atypical cycloadditions, radical-mediated coupling reactions, and iterative scaffold remodeling. This review summarizes major advances in enzyme discovery in plant natural product biosynthesis in recent years, focusing on emerging catalytic mechanisms, strategies for elucidating pathways, and evolutionary relationships, and highlights their implications for synthetic biology, metabolic engineering, and the sustainable production of valuable natural products.
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5. Macropa derivatives for radiopharmaceutical and rare-earth element separation.
PMID:日期:2026-10-01Recognition of large f-block ions underlies advances in targeted radionuclide therapy and rare-earth element separations. Like the lanthanide-binding protein lanmodulin, the 18-membered macrocycle macropa displays reverse-size selectivity characterized by its preference for binding large metal ions. Its diaza-18-crown-6 scaffold enables efficient complexation of therapeutically relevant radiometals, such as Ac, Ra, and Bi, while accommodating diagnostic partners, including Pb and radiolanthanides. In parallel, systematic differences in stability constants across the lanthanide series enable size-based discrimination in separation chemistry. Macropa and its derivatives have been deployed in different strategies to recover and purify rare-earth elements and minor actinides. This manuscript describes recent studies on modifications of macropa, including cavity expansion, alteration of donor atoms, backbone rigidification, chelator-embedded F incorporation, and acyclic variants to demonstrate that effective selectivity arises from balancing preorganization, donor strength, and conformational adaptability. These studies establish macropa-based scaffolds as synthetic systems that bridge radiopharmaceutical coordination chemistry and rare-earth element separations.
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6. Small molecules for genetically encoded control and imaging of protein proximity.
PMID:日期:2026-10-01Many cellular processes are regulated through the conditional association of existing proteins, motivating methods that provide precise spatial control over protein proximity. Controlling and imaging protein proximity in living cells has traditionally relied on separate tools: chemical actuators to induce protein interactions and fluorescent reporters to monitor protein proximity. Chemically induced proximity (CIP) achieves this by using small molecules to conditionally recruit one protein to another. Here, we review the evolution of CIP strategies from non-covalent to covalent and hybrid systems, and discuss recent scaffold designs that combine proximity induction and optical reporting within a single molecular scaffold. These advances establish modern CIP scaffolds as unified platforms for simultaneously controlling and imaging protein interactions.
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7. Glycosyltransferases: Capturing catalytic states and conformational gating.
PMID:日期:2026-10-01Glycosyltransferases (GTs) install and remodel glycans that regulate protein function and shape extracellular matrices and microbial envelopes. Recent high-resolution structures, enabled by cryo-EM and X-ray crystallography, and increasingly complemented by AI-assisted modeling, now capture GTs in mechanistically informative states, including donor-acceptor complexes, gated conformations, and membrane polymerases engaged with nascent chains. In parallel, molecular simulations, including MD and QM/MM methodologies, are being used in selected GTs to map free-energy landscapes and resolve how active-site electrostatics and conformational changes tune reaction pathways across the S1-S2 continuum. We highlight recent advances in protein-directed GTs that initiate glycosylation on Ser/Thr, hydroxylysine, Asn, or Arg, and in glycan remodeling GTs that modify mature N-glycans or lipid-linked oligomannose precursors. We also discuss polymerizing and lipid-acceptor GTs that couple catalysis to translocation, scaffolding, or product release. Together, these studies show how transient catalytic states, loop closure, acceptor distortion, and atypical catalytic strategies control reaction trajectory, substrate selectivity, and processivity, while exposing opportunities for inhibition.
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8. Chemical biology tools for the O-GlcNAc modification: Determining systems-level functions and druggability.
PMID:日期:2026-10-01How can a single monosaccharide control nearly every human cellular feature? This question has hounded the O-GlcNAc field since 1984. Despite identifying thousands of O-GlcNAc proteins, high-throughput datasets have only deepened the mystery. This Current Opinion highlights chemical biology tools (current as of 2023-2026) that reveal coordinated O-GlcNAc networks in physiology and disease. We review five areas: (1) systems-level maps of tissue-specific OGT interactomes and substrates; (2) spatiotemporal tools for precise glycosylation manipulation; (3) multiplexed detection assays for O-GlcNAc activities alongside other PTMs; (4) targeted modulation via nontraditional inhibitors, noncatalytic OGT scaffolding, and ligand-directed assembly; and (5) disease models uncovering tissue-specific effects. Recent OGA inhibitor clinical challenges in Phase 1 and 2 studies pose existential questions about drugging O-GlcNAc, but recent advances covered in this Opinion propose insights for safe therapeutic targeting. Through the lens of new chemical biology tools, we see detailed patterns in how nutrient-responsive O-GlcNAcylation subtly regulates cellular decision-making.
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9. Recent advancements in radiometal chelation for targeted applications in nuclear medicine.
PMID:日期:2026-10-01In recent years, the rapid clinical advancement and expansion of nuclear imaging and therapy agents have (re)invigorated the field of radioisotope research due to progress and wider accessibility of radioisotope production. Many isotopes with decay properties suitable for imaging and therapy can be produced using low-energy cyclotrons; however, chemical labeling strategies enabling the incorporation of these isotopes into disease-/tissue-targeted radiopharmaceuticals are an active and rapidly expanding area of research. In this review, we survey key contemporary radiometal chelation strategies. One strategy encompasses the use of multifunctional, promiscuous azamacrocyclic chelators capable of binding divalent and trivalent radioactive isotopes for positron emission tomography, single-photon emission computed tomography, and radiotherapy with β or α emitters of disparate sizes, charges, and chemical properties. The second strategy focuses on natural-product inspired and oxygen-rich approaches, capitalizing on their high affinity for biologically inert, high valent trivalent/tetravalent and pentavalent, oxophilic metal ions.
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10. Discovery and engineering of enzymes for new-to-nature photobiocatalysis.
PMID:日期:2026-10-01Photobiocatalysis integrates enzymatic catalysis with photochemistry, enabling challenging radical transformations with high selectivity under mild conditions. Early developments in this field were largely driven by the discovery that enzyme-bound cofactors can form photoactive charge-transfer complexes with substrates, thereby initiating radical chemistry upon light irradiation. Recent advances, however, have substantially expanded the mechanistic landscape of photobiocatalysis through diverse mechanisms. This review summarizes major developments in photobiocatalysis reported since 2024. Rather than cataloging individual reactions, we focus on the fundamental mechanisms of radical generation and interception within enzyme active sites, and discuss how these mechanistic principles guide the discovery, engineering, and design of enzymes for new-to-nature photobiocatalysis.