血清25-羟基维生素D浓度作为急性缺血性卒中患者的生物标志物和免疫调节剂：一项回顾性单中心研究
Serum 25-Hydroxyvitamin D Concentration as a Biomarker and Immunomodulator in Patients with Acute Ischemic Stroke: A Retrospective Single-Center Study.
摘要(中文译文)
多项研究显示，血清25-羟基维生素D[25(OH)D]浓度与急性缺血性卒中（AIS）风险呈负相关。本研究旨在确定25(OH)D浓度与AIS治疗病程及结局、脑损伤炎症反应指标水平之间的关系。对2020年1月1日至2025年5月31日期间在单一中心住院的1381例真实世界AIS患者的病历资料进行回顾性分析，评估血清25(OH)D水平、多项炎症指标及临床数据。与25(OH)D浓度最低四分位组患者相比，最高四分位组患者住院时间更短、全因死亡风险更低、改良Rankin量表（mRS）残疾评分更低。随着25(OH)D四分位数的升高，我们发现：中性粒细胞计数降低；葡萄糖、HbA1c、白蛋白、C反应蛋白（CRP）以及CRP与白蛋白、淋巴细胞、中性粒细胞和血小板的比值降低；中性粒细胞与淋巴细胞比值及中性粒细胞与白蛋白比值降低，全身免疫炎症指数和全身炎症反应指数亦降低。在多因素logistic回归分析中，25(OH)D四分位数（OR，95% CI：1.52，1.09-2.12；= 0.012）是唯一与出院时mRS评分≤2呈正相关的变量，而中性粒细胞与淋巴细胞比值、年龄、糖尿病及血管内机械取栓治疗是出院时功能状态不良的生物标志物。AIS患者较高的25(OH)D浓度与更好的生存率、更低水平的炎症反应指标及出院时更低的残疾程度相关。
Abstract
: Several studies reveal an inverse relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and the risk of acute ischemic stroke (AIS). The aim of this study was to determine relationships between 25(OH)D concentration and the course and outcomes of AIS treatment and the level of indices of inflammatory response to brain injury. Retrospective analysis of medical documentation of 1381 real-world AIS patients hospitalized in a single center between 1 January 2020 and 31 May 2025. Serum 25(OH)D level, several inflammatory indices, and clinical data were assessed. : Compared to patients in the lowest quartile of 25(OH)D concentration, those in the highest quartile had a shorter length of in-hospital stay, a lower risk of all-cause death, and a lower score for disability on a modified Rankin scale (mRS). Along with an increase in 25(OH)D quartiles, we found: a decrease in neutrophil count; a decrease in glucose, HbA1c, albumin, C-reactive protein (CRP), and CRP-to-albumin, -lymphocyte, -neutrophil, and -platelet ratios; lower neutrophil-to-lymphocyte and -albumin ratios, and lower systemic immune inflammation, and systemic inflammation response indices. In multifactorial logistic regression, the quartile of 25(OH)D (OR, 95% CI: 1.52, 1.09-2.12; = 0.012) was the only variable to have a positive association with a mRS score ≤ 2 at discharge from hospital, and neutrophil-to-lymphocyte ratio, age, diabetes, and treatment with endovascular mechanical thrombectomy were biomarkers of poor functional status at discharge. Higher 25(OH)D concentration in AIS patients is related to better survival and a lower level of inflammatory response indices and disability at discharge.
如何引用
AMA
Milena Świtońska, Agnieszka Rogalska, Alicja Szulc, Oliwia Jarosz, Magdalena Konieczna-Brazis, Łukasz Wołowiec, et al. Serum 25-Hydroxyvitamin D Concentration as a Biomarker and Immunomodulator in Patients with Acute Ischemic Stroke: A Retrospective Single-Center Study.. Nutrients. 2026; doi:10.3390/nu18132179.
APA
Milena Świtońska, Agnieszka Rogalska, Alicja Szulc, Oliwia Jarosz, Magdalena Konieczna-Brazis, Łukasz Wołowiec, et al (2026). Serum 25-Hydroxyvitamin D Concentration as a Biomarker and Immunomodulator in Patients with Acute Ischemic Stroke: A Retrospective Single-Center Study.. Nutrients. https://doi.org/10.3390/nu18132179
GB/T 7714
Milena Świtońska, Agnieszka Rogalska, Alicja Szulc, Oliwia Jarosz, Magdalena Konieczna-Brazis, Łukasz Wołowiec, et al. Serum 25-Hydroxyvitamin D Concentration as a Biomarker and Immunomodulator in Patients with Acute Ischemic Stroke: A Retrospective Single-Center Study.[J]. Nutrients, 2026 doi:10.3390/nu18132179.
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