纳豆可能通过激活肠道菌群-胆汁酸轴及OPG/RANKL信号通路减轻维甲酸诱导的骨质疏松症
Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.
摘要(中文译文)
纳豆是一种有益于骨骼健康的知名发酵豆制品，但其作用机制尚不明确。本研究探讨了纳豆对小鼠继发性骨质疏松症（OP）的影响。纳豆显著抑制了OP小鼠的体重下降、骨质量恶化和骨形态学损伤，并调节了OPG/RANKL通路蛋白表达（<0.05）。16S rRNA分析显示，纳豆增加了肠道微生物α多样性以及 、 、 的丰度，同时减少了 、 、 等有害细菌。这些微生物变化与OP小鼠的体重、骨骼大小和血清成骨代谢呈正相关。血清代谢组学显示，纳豆组的差异代谢物富集于PPAR信号通路和初级胆汁酸生物合成。mRNA和ELISA验证表明，纳豆上调的肝脏和循环PPARα可能调节下游胆汁酸通路，将肠道微生物与多器官代谢功能联系起来。总之，纳豆可能通过“肠道微生物-胆汁酸-OPG/RANKL”网络作用于肠道微生物以缓解骨丢失，靶向肠道、肝脏和骨骼等多个器官。这为通过肠-骨轴进行纳豆饮食干预预防骨质疏松症提供了理论依据。
Abstract
Natto, a well-known fermented soybean product beneficial for bone health, remains unclear in its mechanism. This study investigated its effect on secondary osteoporosis (OP) in mice. Natto significantly inhibited weight loss, bone quality deterioration, and bone morphological damage, and regulated OPG/RANKL pathway protein expression ( < 0.05) in OP mice. Analysis of 16S rRNA revealed that natto increased gut microbiota α-diversity and the abundance of , , and , while reducing harmful bacteria such as , , and . These microbial changes positively correlated with body weight, bone size, and serum osteogenic metabolism in OP mice. Serum metabolomics showed differential metabolites of the natto group enriched in PPAR signaling and primary bile acid biosynthesis. Verification by mRNA and ELISA indicated that the upregulated liver and circulating PPARα by natto may regulate downstream bile acid pathways, linking gut microbiota to multi-organ metabolic functions. In summary, natto may act on gut microbiota to alleviate bone loss via the "gut microbiota-bile acid-OPG/RANKL" network, targeting multiple organs including gut, liver, and bone. This provides a theoretical basis for natto dietary intervention in osteoporosis prevention through the gut-bone axis.
如何引用
AMA
Bimi Zhang, Mubai Sun, Yongfu Liu, Tong Pan, Xuecong Zhang, Yuguang He, et al. Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.. Nutrients. 2026; doi:10.3390/nu18121927.
APA
Bimi Zhang, Mubai Sun, Yongfu Liu, Tong Pan, Xuecong Zhang, Yuguang He, et al (2026). Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.. Nutrients. https://doi.org/10.3390/nu18121927
GB/T 7714
Bimi Zhang, Mubai Sun, Yongfu Liu, Tong Pan, Xuecong Zhang, Yuguang He, et al. Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.[J]. Nutrients, 2026 doi:10.3390/nu18121927.
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