膳食胶原补充作为皮肤健康策略：对皮肤、头发、指甲及伤口愈合临床效果的叙述性综述
Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
摘要(中文译文)
胶原蛋白是皮肤的关键结构蛋白，对维持皮肤的机械强度、弹性和水合作用至关重要。口服胶原蛋白补充剂，特别是以胶原蛋白肽的形式，近年来作为一种支持皮肤健康和整体健康的营养策略引起了广泛关注。然而，关于其在支持皮肤健康以及改善头发、指甲和伤口愈合结局方面的有效性证据仍存在异质性。本综述旨在总结和批判性评价当前关于口服胶原蛋白补充剂及其在支持皮肤健康、头发和指甲质量以及伤口愈合方面潜在作用的人体研究证据。通过PubMed和Web of Science进行了针对性文献检索，以识别评估胶原蛋白补充剂对皮肤老化参数（包括弹性、皱纹、水合作用和屏障功能）以及脱发、指甲疾病和伤口愈合影响的临床试验和相关研究。补充胶原蛋白衍生肽与皮肤水合作用、弹性、皱纹外观和真皮细胞外基质组织的改善相关，同时还支持头发厚度和强度、适度促进指甲生长并促进伤口愈合。获益与低分子量、富含羟脯氨酸的肽最为一致，肽的特征似乎比胶原蛋白来源更为重要。证据受到研究持续时间短、设计异质性、多成分配方和行业资助的限制，这些因素降低了对所报告效应大小和一致性的信心。尽管如此，仍需要具有标准化结局的高质量、长期、独立资助的试验来证实这些发现。
Abstract
Collagen is a key structural protein of the skin, essential for maintaining its mechanical strength, elasticity, and hydration. Oral collagen supplementation, particularly in the form of collagen peptides, has recently gained significant interest as a nutritional strategy to support skin health and overall wellbeing. However, the evidence regarding its effectiveness in supporting skin health and improving hair, nail, and wound-healing outcomes remains heterogeneous. The aim of this review is to summarize and critically evaluate the current human evidence on oral collagen supplementation and its potential role in supporting skin health, hair and nail quality, and wound healing. A targeted literature search was conducted using PubMed and Web of Science to identify clinical trials and relevant studies assessing the effects of collagen supplementation on skin aging parameters, including elasticity, wrinkles, hydration, and barrier function, as well as hair loss, nail disorders, and wound healing. Collagen-derived peptide supplementation has been associated with improvements in skin hydration, elasticity, wrinkle appearance, and dermal extracellular matrix organization, while also supporting hair thickness and strength, modestly enhancing nail growth, and promoting wound healing. Benefits are most consistent with low-molecular-weight hydroxyproline-rich peptides, with peptide characteristics appearing more important than collagen source. Evidence is limited by short study durations, heterogeneous designs, multi-ingredient formulations, and industry funding, which reduce confidence in the magnitude and consistency of the reported effects. Nevertheless, high-quality, long-term, independently funded trials with standardized outcomes are still required to confirm these findings.
如何引用
AMA
Angelika Biełach-Bazyluk, Marta Jurga, Iwona Flisiak, Edyta Zbroch. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.. Nutrients. 2026; doi:10.3390/nu18132141.
APA
Angelika Biełach-Bazyluk, Marta Jurga, Iwona Flisiak, Edyta Zbroch (2026). Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.. Nutrients. https://doi.org/10.3390/nu18132141
GB/T 7714
Angelika Biełach-Bazyluk, Marta Jurga, Iwona Flisiak, Edyta Zbroch. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.[J]. Nutrients, 2026 doi:10.3390/nu18132141.
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