在神经退行性疾病背景下，高饮食炎症指数得分与肠和血脑屏障完整性之间的关系
Relationships Between High Dietary Inflammatory Index Scores and Intestinal and Blood-Brain Barrier Integrity in the Context of Neurodegenerative Diseases.
摘要(中文译文)
饮食对人类健康的影响正不断被研究。营养是影响基因表达最有力的工具之一，饮食习惯可促进肥胖、糖尿病、心血管疾病、癌症和神经退行性疾病（NDs）遗传易感性的表达。饮食炎症指数（DII）是一种数值评分，用于评估特定饮食的促炎或抗炎潜力。根据高DII评分，西方饮食或标准美国饮食（SAD）具有促炎特性。SAD通过破坏肠道微生物组，在肠道中营造不利环境，这与低度全身性炎症反应和氧化改变相关，可能促进NDs的发生发展。肠道通透性增加和血脑屏障（BBB）完整性丧失在饮食依赖性NDs的病理机制中发挥关键作用，通过肠-脑轴导致促炎信号传导。本叙述性综述旨在详细呈现当前关于肠-脑轴功能的知识现状，该功能取决于以DII衡量的饮食促炎/抗炎潜力，并结合肠道和BBB通透性障碍对NDs发生的贡献进行探讨。
Abstract
The impact of diet on human health is constantly being researched. Nutrition is one of the most powerful tools for influencing gene expression, and dietary habits can promote the expression of genetic predisposition to obesity, diabetes, cardiovascular disease, cancer, and neurodegenerative diseases (NDs). The dietary inflammatory index (DII) is a numerical score that assesses the pro-or anti-inflammatory potential of a given diet. According to high DII scores, a Western diet or a standard American diet (SAD) has proinflammatory properties. By disrupting the gut microbiome, SAD creates an unfavorable environment in the intestine that is associated with a low-grade systemic inflammatory response and oxidative changes that may promote the development of NDs. An increased intestinal permeability and loss of blood-brain barrier (BBB) integrity play key roles in the pathomechanisms of diet-dependent NDs, leading to proinflammatory signaling via the gut-brain axis. The aim of this narrative review is to present in detail the current state of knowledge on the function of the gut-brain axis depending on the pro-/anti-inflammatory potential of the diet, measured by the DII, in the context of the contributions of intestinal and BBB permeability disorders to the development of NDs.
如何引用
AMA
Dariusz Szukiewicz, Juliana Almeida-de-Souza, Małgorzata Gryka-Marton, Mateusz Wątroba, Anna D Grabowska. Relationships Between High Dietary Inflammatory Index Scores and Intestinal and Blood-Brain Barrier Integrity in the Context of Neurodegenerative Diseases.. Nutrients. 2026; doi:10.3390/nu18132106.
APA
Dariusz Szukiewicz, Juliana Almeida-de-Souza, Małgorzata Gryka-Marton, Mateusz Wątroba, Anna D Grabowska (2026). Relationships Between High Dietary Inflammatory Index Scores and Intestinal and Blood-Brain Barrier Integrity in the Context of Neurodegenerative Diseases.. Nutrients. https://doi.org/10.3390/nu18132106
GB/T 7714
Dariusz Szukiewicz, Juliana Almeida-de-Souza, Małgorzata Gryka-Marton, Mateusz Wątroba, Anna D Grabowska. Relationships Between High Dietary Inflammatory Index Scores and Intestinal and Blood-Brain Barrier Integrity in the Context of Neurodegenerative Diseases.[J]. Nutrients, 2026 doi:10.3390/nu18132106.
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