FUT2介导的肠道岩藻糖基化：健康与疾病中宿主-微生物群共生关系的主要调控者
FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.
摘要(中文译文)
肠道岩藻糖基化，即通过酶促反应将岩藻糖添加到糖缀合物上的过程，是调节胃肠道中宿主-微生物群相互作用的关键调控机制。本综述系统整合了肠黏膜岩藻糖基化的分子机制、多层次调控网络及功能意义方面的最新进展。本综述聚焦于由岩藻糖基转移酶2（FUT2）催化的α(1,2)-岩藻糖基化反应——该反应决定分泌者状态并修饰关键糖缀合物，包括黏蛋白和人乳寡糖。本综述审视了宿主来源因子对上皮岩藻糖基化的动态调控，包括免疫介质[特别是3型先天淋巴细胞（ILC3s）分泌的白细胞介素-22（IL-22）]、肠神经系统（ENS）及微生物信号。此外，本综述详细阐述了岩藻糖基化聚糖如何通过作为有益共生菌（包括 和 菌种）的选择性营养来源来塑造肠道微生物生态系统，同时增强对肠道病原体的定植抵抗。该轴的失调日益被认为与一系列人类疾病相关，包括炎症性肠病（IBD）、代谢功能障碍和肠道感染。最后，本综述讨论了靶向调节肠道岩藻糖基化及其下游生理后果的新兴治疗策略，特别强调基于宿主遗传决定因素——尤其是分泌者状态——的个性化方法。
Abstract
Intestinal fucosylation, the enzymatic addition of fucose to glycoconjugates, represents a pivotal regulatory mechanism that modulates host-microbiota crosstalk in the gastrointestinal tract. This review comprehensively synthesizes current advances in the molecular mechanisms, multilevel regulatory networks, and functional implications of intestinal mucosal fucosylation. This review focuses on α(1,2)-fucosylation catalyzed by fucosyltransferase 2 (FUT2)-a reaction that determines the secretor status and modifies critical glycoconjugates, including mucins and human milk oligosaccharides. This review examines the dynamic regulation of epithelial fucosylation by host-derived factors-including immune mediators [notably interleukin-22 (IL-22) secreted by group 3 innate lymphoid cells (ILC3s)], the enteric nervous system (ENS), and microbial signals. Furthermore, this review details how fucosylated glycans shape the gut microbial ecosystem by serving as selective nutrient sources for beneficial symbionts-including and species-while concurrently enhancing colonization resistance against enteric pathogens. Dysregulation of this axis is increasingly associated with a spectrum of human pathologies, including inflammatory bowel disease (IBD), metabolic dysfunction, and enteric infections. Finally, this review discusses emerging therapeutic strategies targeting the modulation of intestinal fucosylation and its downstream physiological consequences, with particular emphasis on personalized approaches informed by host genetic determinants-most notably secretor status.
如何引用
AMA
Lifen Zhao, Nianzhu Zhang. FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.. Frontiers in microbiology. 2026; doi:10.3389/fmicb.2026.1926158.
APA
Lifen Zhao, Nianzhu Zhang (2026). FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.. Frontiers in microbiology. https://doi.org/10.3389/fmicb.2026.1926158
GB/T 7714
Lifen Zhao, Nianzhu Zhang. FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.[J]. Frontiers in microbiology, 2026 doi:10.3389/fmicb.2026.1926158.
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