脑肿瘤中髓系细胞的代谢
Metabolism of myeloid cells in brain tumors.
摘要(中文译文)
原发性和复发性脑肿瘤是侵袭性恶性肿瘤，死亡率高且治疗选择有限。尤其是胶质母细胞瘤（GBM），尽管肿瘤微环境（TME）中存在相当比例的免疫细胞，但对免疫治疗在很大程度上仍难治。越来越多的证据表明，脑肿瘤中的免疫抑制性TME是由驻留和浸润性髓系细胞的功能与代谢重编程所驱动。本文探讨了脑肿瘤中免疫代谢格局的决定因素以及异质性髓系细胞群体的独特特征。我们讨论了细胞类型之间的相互作用与代谢程序如何塑造空间生态位。我们进一步剖析了肿瘤分期、类型和治疗对TME代谢特征的影响。总体而言，本系统综述概述了脑肿瘤中的髓系细胞代谢，并强调了未来针对代谢状态开展癌症免疫治疗研究的潜在机遇。
Abstract
Primary and recurrent brain tumors are aggressive malignancies with high mortality rates and limited treatment options. Glioblastoma (GBM) in particular are largely refractory to immunotherapies despite harboring a significant proportion of immune cells in the tumor microenvironment (TME). Increasing evidence suggests that the immunosuppressive TME in brain tumors is driven by functional and metabolic reprogramming of resident and infiltrating myeloid cells. Here, we examine the determinants of immunometabolic landscape in brain tumors and distinct features of heterogeneous myeloid cell populations. We discuss how interactions between cell types and metabolic programs shape spatial niches. We further dissect the effect of tumor stage, type and therapy in informing metabolic features of the TME. Collectively, this systematic review provides an overview of myeloid cell metabolism in brain tumors and highlights potential opportunities for future studies targeting metabolic states for cancer immunotherapy.
如何引用
AMA
Aashna Saxena, Defne Bayik. Metabolism of myeloid cells in brain tumors.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1894833.
APA
Aashna Saxena, Defne Bayik (2026). Metabolism of myeloid cells in brain tumors.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1894833
GB/T 7714
Aashna Saxena, Defne Bayik. Metabolism of myeloid cells in brain tumors.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1894833.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出