IL-33-ILC2轴：呼吸系统疾病中2型免疫的关键调节因子
The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.
摘要(中文译文)
呼吸系统疾病构成全球重大公共卫生负担，2型免疫在其发病机制中发挥关键作用。白细胞介素-33（IL-33）-2型固有淋巴细胞（ILC2）轴调控气道2型免疫反应，从而触发、放大并维持病理性炎症。本综述阐述IL-33与肺ILC2的特征，包括IL-33的警报素功能及组织特异性表达，以及ILC2的来源、定位、功能异质性和微环境驱动的可塑性。特别讨论疾病特异性微环境如何塑造不同的ILC2状态，包括经典产2型细胞因子的ILC2、组织修复性产AREG的ILC2、ILC1样细胞及产IL-17的ILC2样状态。进一步综述IL-33-ILC2轴在支气管肺发育不良、哮喘、慢性阻塞性肺疾病、肺纤维化及病毒性呼吸道感染中的调控机制，突显ILC2显著的功能可塑性。靶向IL-33-ILC2轴及调控ILC2功能是多种2型免疫介导气道疾病的治疗策略。
Abstract
Respiratory diseases represent a major global public health burden, and type 2 immunity plays a key role in their pathogenesis. The interleukin-33 (IL-33)-group 2 innate lymphoid cell (ILC2) axis regulates airway type 2 immune responses, thereby triggering, amplifying, and maintaining pathological inflammation. This review addresses the characteristics of IL-33 and pulmonary ILC2s, including the alarmin function and tissue-specific expression of IL-33, and the origin, localization, functional heterogeneity, and microenvironment-driven plasticity of ILC2s. In particular, we discuss how disease-specific microenvironments shape divergent ILC2 states, including classical type 2 cytokine-producing ILC2s, tissue-repairing AREG-producing ILC2s, ILC1-like cells, and IL-17-producing ILC2-like states. We further review the regulatory mechanisms of the IL-33-ILC2 axis in bronchopulmonary dysplasia, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and viral respiratory infections are also discussed, highlighting the remarkable functional plasticity of ILC2s. Targeting the IL-33-ILC2 axis and modulating ILC2 function represent therapeutic strategies for various type 2-mediated airway diseases.
如何引用
AMA
Yue Zhu, Yi Zhang, Rui Cheng. The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1891857.
APA
Yue Zhu, Yi Zhang, Rui Cheng (2026). The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1891857
GB/T 7714
Yue Zhu, Yi Zhang, Rui Cheng. The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1891857.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出