肠道-肝脏轴功能失调的巨噬细胞：肝硬化感染的驱动因素
Dysfunctional macrophages along the gut-liver axis: a driver of infection in cirrhosis.
摘要(中文译文)
肝硬化患者极易发生感染，而感染可触发一系列恶性循环事件，包括肝功能失代偿、器官衰竭和死亡率增加。这些感染通常起源于胃肠道，当细菌突破肠道屏障并向肝脏播散时即可发生。巨噬细胞是肠-肝轴上的关键免疫细胞，在稳态条件下对维持屏障完整性起着至关重要的作用。然而，在肝硬化中，巨噬细胞的特化、空间组织分布及抗菌功能均受到破坏。在本综述中，我们讨论了在理解肠道和肝脏巨噬细胞异质性方面所取得的进展，重点强调其不同的个体发育起源以及决定其功能的特化微环境。我们阐述了这些细胞群体在健康状态下所发挥的作用，特别是在衬覆肠-肝轴内关键细胞屏障方面的作用，随后讨论了这些过程在肝硬化背景下如何受损。最后，我们探讨了在晚期肝病中治疗策略如何靶向失调的巨噬细胞或恢复其屏障保护功能。
Abstract
Patients with cirrhosis are highly susceptible to infections which could trigger a vicious cycle of events, including hepatic decompensation, organ failure, and increased mortality. These infections often originate from the gastrointestinal tract when bacteria breach the intestinal barrier and disseminate towards the liver. Macrophages are key immune cells along the gut-liver axis, where they play a crucial role in preserving barrier integrity under homeostatic conditions. In cirrhosis, however, macrophage specialization, spatial organization, and antimicrobial functions are disrupted. In this review, we discuss the progress made in understanding the heterogeneity of intestinal and hepatic macrophages, emphasizing their distinct ontogeny and the specialized niches that dictate their function. We describe the roles these populations perform in health, particularly in lining critical cellular barriers within the gut-liver axis, followed by how these processes are compromised in the context of cirrhosis. Finally, we explore how therapeutic approaches might target dysregulated macrophages or restore their barrier-protective functions in advanced liver disease.
如何引用
AMA
Devrim Aslan, Hannelie Korf, Alexander Dumarey, Lena Smets, Ahmed Ghallab, Jan G Hengstler, et al. Dysfunctional macrophages along the gut-liver axis: a driver of infection in cirrhosis.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1870116.
APA
Devrim Aslan, Hannelie Korf, Alexander Dumarey, Lena Smets, Ahmed Ghallab, Jan G Hengstler, et al (2026). Dysfunctional macrophages along the gut-liver axis: a driver of infection in cirrhosis.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1870116
GB/T 7714
Devrim Aslan, Hannelie Korf, Alexander Dumarey, Lena Smets, Ahmed Ghallab, Jan G Hengstler, et al. Dysfunctional macrophages along the gut-liver axis: a driver of infection in cirrhosis.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1870116.
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