特应性皮炎和肠道皮肤轴：从生态失调到新的靶向治疗策略的综述
Atopic dermatitis and the gut-skin axis: a review from dysbiosis to novel targeted therapeutic strategies.
摘要(中文译文)
特应性皮炎（AD）是一种常见的慢性、复发性、炎症性皮肤病，其发病机制复杂，涉及遗传、免疫和环境因素。近年来，肠-皮肤轴（GSA）研究的进展为AD的病理生理学提供了新的认识，突出了肠道菌群失调在免疫调节和炎症反应中的关键作用。本综述总结了AD中肠道和皮肤微生物失调及其对免疫稳态的影响，阐述了肠-皮肤轴功能障碍驱动AD炎症的分子/细胞机制，并重点介绍了靶向调控肠-皮肤轴的治疗策略。本文概述了相关干预措施的最新研究和临床转化进展，包括益生菌、益生元、后生元、饮食调整、粪菌移植以及靶向微生物/代谢物的生物制剂，为AD的精准管理和新型治疗开发提供了理论基础。
Abstract
Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disorder with a complex pathogenesis involving genetic, immune, and environmental factors. Recent advances in the research on the gut-skin axis (GSA) have shed new light on the pathophysiology of AD, highlighting the critical role of gut microbiota dysbiosis in immune regulation and inflammatory responses. This review summarizes gut and skin microbial dysbiosis in AD and its impact on immune homeostasis, elaborates on molecular/cellular mechanisms by which gut-skin axis dysfunction drives AD inflammation, and focuses on targeted therapeutic strategies for gut-skin axis modulation. It outlines the latest research and clinical translation of interventions, including probiotics, prebiotics, postbiotics, dietary adjustments, fecal microbiota transplantation, and microbe/metabolite-targeted biologics, providing a theoretical basis for AD precision management and novel therapeutic development.
如何引用
AMA
Ruzhen Peng, Xiao Huang, Yindi Bao, Guangwen Luo, Junfen Zeng, Liu Tang. Atopic dermatitis and the gut-skin axis: a review from dysbiosis to novel targeted therapeutic strategies.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1895580.
APA
Ruzhen Peng, Xiao Huang, Yindi Bao, Guangwen Luo, Junfen Zeng, Liu Tang (2026). Atopic dermatitis and the gut-skin axis: a review from dysbiosis to novel targeted therapeutic strategies.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1895580
GB/T 7714
Ruzhen Peng, Xiao Huang, Yindi Bao, Guangwen Luo, Junfen Zeng, Liu Tang. Atopic dermatitis and the gut-skin axis: a review from dysbiosis to novel targeted therapeutic strategies.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1895580.
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