组织侧记忆T细胞在腔屏障和癌症早期阻断期间重塑原位免疫监测
{"_":"Tissue-resident memory T cells reshape immune surveillance at luminal barriers and during early cancer interception.","i":["in situ"]}
摘要(中文译文)
组织驻留记忆T（TRM）细胞为理解屏障组织如何在危险发生的最早部位感知、限制和放大免疫反应提供了一个概念框架。TRM视角并非主要通过再循环细胞的延迟募集来审视免疫记忆，而是将免疫记忆置于特定的组织微环境中，在那里细胞位置、抗原经历、外出限制、代谢适应和局部细胞相互作用共同决定了免疫监视的质量。本文概述了TRM细胞的概念演变和定义边界，区分了管腔屏障两侧互补的CD4和CD8 TRM程序，并特别强调TRM细胞在肿瘤监视、免疫治疗反应、癌前微环境和乳腺导管拦截中的作用。我们还整合了近期人类生殖道表型分析数据，将TRM状态与临床相关的组织背景联系起来。我们认为，未来的TRM研究应超越基于CD69或CD103的注释，转而构建整合多组学、空间生物学、TCR克隆性和功能验证的证据链。乳腺导管并非经典的黏膜器官，但它可能成为一个关键场景，用以检验基于TRM的免疫学原理能在多大程度上扩展至癌症预防和局部免疫干预。
Abstract
Tissue-resident memory T (TRM) cells provide a conceptual framework for understanding how barrier tissues sense, restrict and amplify immune responses at the earliest sites of danger. Rather than viewing memory primarily through the delayed recruitment of recirculating cells, the TRM perspective places immune memory within defined tissue niches, where cellular position, antigen experience, egress restraint, metabolic adaptation and local cellular interactions collectively determine the quality of surveillance. Here we outline the conceptual evolution and definitional boundaries of TRM cells, distinguish complementary CD4 and CD8 TRM programmes across luminal barriers, and place particular emphasis on TRM cells in tumour surveillance, immunotherapy response, precancerous niches and mammary duct interception. We also integrate recent human reproductive tract phenotyping data to link TRM states with clinically relevant tissue contexts. We argue that future TRM studies should move beyond CD69 or CD103-based annotation and instead build evidence chains that integrate multi-omics, spatial biology, TCR clonality and functional validation. The mammary duct is not a classical mucosal organ, but it may become a critical setting in which to test how far TRM-based principles of immunity can be extended to cancer prevention and local immune intervention.
如何引用
AMA
Yimin Qin, Senyang Guo, Wei Chen, Xuan Ji, Jianhua Liu, Hongmei Zheng. {"_":"Tissue-resident memory T cells reshape immune surveillance at luminal barriers and during early cancer interception.","i":["in situ"]}. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1877664.
APA
Yimin Qin, Senyang Guo, Wei Chen, Xuan Ji, Jianhua Liu, Hongmei Zheng (2026). {"_":"Tissue-resident memory T cells reshape immune surveillance at luminal barriers and during early cancer interception.","i":["in situ"]}. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1877664
GB/T 7714
Yimin Qin, Senyang Guo, Wei Chen, Xuan Ji, Jianhua Liu, Hongmei Zheng. {"_":"Tissue-resident memory T cells reshape immune surveillance at luminal barriers and during early cancer interception.","i":["in situ"]}[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1877664.
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