炎症放大的统一模型：秋水仙碱对心脏代谢和传染病的见解
A Unifying Model of Inflammatory Amplification: Insights From Colchicine Across Cardiometabolic and Infectious Disease.
摘要(中文译文)
炎症是传统上被视为互不相同的疾病（包括病毒感染、冠状动脉疾病和代谢紊乱）所共有的生物学过程。尽管临床表现各异，这些疾病均由共同的免疫炎症通路驱动。本综述阐述了先天免疫系统与适应性免疫系统之间的相互作用如何失调，进而导致以持续性免疫激活、细胞因子信号传导和组织损伤为特征的自放大炎症循环。在此框架内，炎症小体激活和免疫代谢功能障碍成为疾病的核心驱动因素。随后探讨了秋水仙碱的作用，将其作为一种靶向炎症放大级联上游组分的治疗模型。最后讨论了新兴治疗策略以及可能有助于指导未来更精准治疗方向的关键空白。
Abstract
Inflammation is a shared biological process underlying diseases that are traditionally viewed as distinct, including viral infections, coronary artery disease, and metabolic disorders. Despite differing clinical presentations, these conditions are driven by common immune-inflammatory pathways. This review describes how interactions between the innate and adaptive immune systems can become dysregulated, leading to a self-amplifying inflammatory cycle characterized by persistent immune activation, cytokine signaling, and tissue injury. Within this framework, inflammasome activation and immunometabolic dysfunction emerge as central drivers of disease. The role of colchicine is then examined as a therapeutic model that targets upstream components of the inflammatory amplification cascade. Finally, emerging therapeutic strategies are discussed, along with key gaps that may help guide more targeted approaches to treatment in the future.
如何引用
AMA
Amir B Rabbani. A Unifying Model of Inflammatory Amplification: Insights From Colchicine Across Cardiometabolic and Infectious Disease.. Cureus. 2026; doi:10.7759/cureus.110588.
APA
Amir B Rabbani (2026). A Unifying Model of Inflammatory Amplification: Insights From Colchicine Across Cardiometabolic and Infectious Disease.. Cureus. https://doi.org/10.7759/cureus.110588
GB/T 7714
Amir B Rabbani. A Unifying Model of Inflammatory Amplification: Insights From Colchicine Across Cardiometabolic and Infectious Disease.[J]. Cureus, 2026 doi:10.7759/cureus.110588.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出