原发性腭裂修复的时机、手术技术和功能结果：临床证据的重点综述
Timing, Surgical Techniques, and Functional Outcomes in Primary Cleft Palate Repair: A Focused Review of Clinical Evidence.
摘要(中文译文)
采用预设检索词，围绕腭裂、腭成形术、手术时机及腭咽功能不全（VPI）等相关主题，在PubMed、Scopus和Web of Science数据库中进行了一项结构化文献综述。旨在评估手术时机与手术技术对原发性腭裂修复术后功能结局的影响，重点关注腭咽功能。纳入报告言语相关结局的随机对照试验（RCT）和观察性队列研究。结果显示，手术时机、手术技术及结局定义方面存在显著异质性。多数观察性研究未显示手术时机与言语结局之间存在统计学显著关联。解剖因素，尤其是裂隙宽度和亚型，与术后结局的相关性更强。现有证据不支持原发性腭修复存在普遍最优的手术时机。功能结局似乎受手术时机以外多种因素的影响，包括手术技术和患者个体特征。需要标准化的结局测量方法和多中心研究以提高可比性并指导临床决策。
Abstract
A structured literature review was conducted across PubMed, Scopus, and Web of Science using predefined search terms related to cleft palate, palatoplasty, timing, and velopharyngeal insufficiency (VPI). The aim was to evaluate the impact of surgical timing and operative techniques on functional outcomes following primary cleft palate repair, with a focus on velopharyngeal function. Randomized controlled trials (RCTs) and observational cohort studies reporting speech-related outcomes were included. Considerable heterogeneity was identified in surgical timing, techniques, and outcome definitions. Most observational studies did not show a statistically significant association between timing and speech outcomes. Anatomical factors, particularly cleft width and subtype, demonstrated a stronger correlation with postoperative outcomes. Current evidence does not support a universally optimal timing for primary palatal repair. Functional outcomes appear to be influenced by multiple factors beyond timing, including surgical technique and patient-specific characteristics. Standardized outcome measures and multicenter studies are needed to improve comparability and guide clinical decision-making.
如何引用
AMA
Geomara N Guerron-Cuenca, Glen A Silva-Rojas, Galo G Farfán-Cano, Kevin J Silva-Rojas. Timing, Surgical Techniques, and Functional Outcomes in Primary Cleft Palate Repair: A Focused Review of Clinical Evidence.. Cureus. 2026; doi:10.7759/cureus.110304.
APA
Geomara N Guerron-Cuenca, Glen A Silva-Rojas, Galo G Farfán-Cano, Kevin J Silva-Rojas (2026). Timing, Surgical Techniques, and Functional Outcomes in Primary Cleft Palate Repair: A Focused Review of Clinical Evidence.. Cureus. https://doi.org/10.7759/cureus.110304
GB/T 7714
Geomara N Guerron-Cuenca, Glen A Silva-Rojas, Galo G Farfán-Cano, Kevin J Silva-Rojas. Timing, Surgical Techniques, and Functional Outcomes in Primary Cleft Palate Repair: A Focused Review of Clinical Evidence.[J]. Cureus, 2026 doi:10.7759/cureus.110304.
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