Cureus Journal of Medical ScienceCureus 医学科学杂志
Cureus Journal of Medical Science(英文缩写 CUREUS J MED SCIENCE),ISSN 2168-8184,eISSN 2168-8184,中文译名:Cureus 医学科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
Cureus Journal of Medical Science 最新收录文献
-
1. Cerebral/Cortical Visual Impairment in Primary Care: Extending the Evidence to Family Medicine.
PMID:日期:2026-09-01Introduction Cerebral/cortical visual impairment (CVI) is a leading cause of childhood visual impairment but remains underrecognized. CVI-related education, awareness, and visual dysfunction screening practices among family medicine physicians remain poorly characterized. This study evaluated CVI education and awareness, visual dysfunction screening, and referral practices among family medicine physicians. This present study evaluated whether similar patterns extend to family medicine physicians. Methods Nebraska family medicine physicians completed an anonymous 60-question electronic survey assessing CVI education and awareness, screening for visual dysfunction in children with neurologic disease, referral practices, and intended use of hypothetical screening tools. Results Fifty-seven responses were analyzed, with varying response numbers for each question. Fifty-four (98.2%) respondents reported no CVI education during residency/fellowship, and 51 (92.7%) reported no CVI continuing medical education. Forty-three (78.2%) respondents also expressed interest in future CVI education. Fifty (92.6%) were unaware of CVI diagnostic criteria, and 38 (70.4%) respondents reported screening for visual dysfunction in children with neurologic disease in 25% of encounters or less. Intended use was greater for shorter hypothetical screening approaches. Referral pathways and reported specialist availability varied. Conclusions Family medicine physicians reported limited CVI education and infrequent visual dysfunction screening. These findings suggest that opportunities to improve CVI education and recognition may extend across primary care specialties. This study also underscores potential opportunities for future efforts to improve recognition of children who may warrant further evaluation for CVI.
-
2. Psoriasis and Psoriatic Arthritis in Pregnancy: Current Evidence and Clinical Considerations.
PMID:日期:2026-09-01Psoriasis and psoriatic arthritis (PsA) are chronic, immune-mediated inflammatory diseases that commonly affect individuals of reproductive age, presenting unique challenges relating to fertility, pregnancy, lactation, and long-term reproductive health. This narrative review summarizes the current evidence on the relationship between psoriatic diseases and pregnancy, focusing particularly on disease activity, fertility, obstetric outcomes, hereditary risk, the psychosocial impact, and treatment options throughout the reproductive journey. The available evidence indicates that psoriasis and PsA can impact reproductive health and fertility, as well as pregnancy outcomes, particularly in individuals with active or severe disease. Chronic systemic inflammation and associated comorbidities likely play an important role in these associations. While pregnancy-related immunological adaptations may improve disease activity in some women, flare-ups remain common during the postpartum period. The management of psoriatic disease during pregnancy has undergone a substantial paradigm shift. Contemporary evidence increasingly supports maintaining adequate disease control throughout the reproductive period with therapies with an established safety profile. This review highlights the evolving understanding of psoriasis and PsA as systemic diseases that extend beyond dermatological and rheumatological manifestations and may influence reproductive health at multiple levels. Future research should focus on the long-term safety of newer targeted therapies, the impact of paternal exposure, patient-reported reproductive outcomes, and developing evidence-based, multidisciplinary care pathways for women with psoriatic disease during pregnancy and the postpartum period.
-
3. Retraction: Recurrent Radiculopathy Caused by an Epidural Cervical Plasmacytoma Revealing Plasma Cell Leukemia: A Case Report and Literature Review.
PMID:日期:2026-09-01[This retracts the article DOI: 10.7759/cureus.114134.].
-
4. A Case of Delayed-Onset Hyphema After PreserFlo MicroShunt Implantation.
PMID:日期:2026-09-01We report a case of delayed-onset hyphema with reflux bleeding adjacent to the PreserFlo MicroShunt (PFM) tube entry site. A 66-year-old Japanese man with bilateral primary open-angle glaucoma underwent PFM implantation in the left eye because of elevated intraocular pressure (IOP) and progressive visual field loss despite treatment with four topical anti-glaucoma agents. He had previously undergone cataract surgery and microhook ab interno trabeculotomy (μLOT) in the same eye. Because of insufficient IOP control and further visual field progression after PFM implantation, Ahmed glaucoma valve implantation with pars plana tube insertion was subsequently performed in combination with 25-gauge pars plana vitrectomy. At two years and three months after PFM implantation, a small number of red blood cells were observed floating in the anterior chamber. Gonioscopy showed that the PFM tube was positioned between the pigmented and non-pigmented trabecular meshwork, with reflux bleeding from both sides of the tube entry site. The previous μLOT clefts did not overlap with the PFM tube entry site. The hyphema resolved with observation alone, although possible recurrence was noted six months later. This case demonstrates that delayed-onset hyphema can occur more than two years after PFM implantation and that careful gonioscopic examination can help identify the source of bleeding.
-
5. A Case of Early PreserFlo MicroShunt Obstruction Following Presumed Inadvertent Ciliary Sulcus Implantation.
PMID:日期:2026-09-01We report a case of early postoperative PreserFlo MicroShunt (PFM; Santen Pharmaceutical Co., Ltd., Osaka, Japan) obstruction following presumed inadvertent ciliary sulcus implantation. A 67-year-old Japanese man with primary open-angle glaucoma underwent superonasal PFM implantation in the right eye, which had previously undergone cataract surgery, scleral buckling, and microhook ab interno trabeculotomy. The preoperative intraocular pressure (IOP) in the right eye was 26 mmHg on two classes of topical IOP-lowering medications. Although the proximal tip was not visible in the anterior chamber, aqueous humor outflow was confirmed intraoperatively, and the device was left in place. On postoperative day 1, IOP was 24 mmHg, and no filtering bleb was observed. The PFM was removed, and a new device was implanted into the anterior chamber through an adjacent scleral tunnel. The IOP was 6 mmHg on postoperative day 1 after the second PFM implantation. Stereomicroscopic examination of the first explanted PFM device revealed intraluminal pigmented tissue fragments consistent with uveal tissue, although their precise origin could not be established. Bleb needling was performed at five weeks because the IOP had increased to 31 mmHg, presumably due to bleb encapsulation. The IOP was 15 mmHg at three months after reoperation. This instructive case illustrates the importance of confirming the scleral tract trajectory and implant position, as apparently satisfactory intraoperative outflow does not ensure sustained tube patency. These findings should not be generalized to the safety or efficacy of intentional ciliary sulcus implantation.
-
6. Acute Poisonings Admitted to the Intensive Care Unit of Cocody University Hospital, Côte d'Ivoire, Africa: Clinical Characteristics and Factors Associated With Intensive Care Unit Mortality.
PMID:日期:2026-09-01Acute poisoning is a common reason for emergency department (ED) visits and intensive care unit (ICU) admission in sub-Saharan Africa. This study aimed to describe the clinical and toxicological characteristics of acute poisonings admitted to the ICU and to identify clinical and circumstantial factors associated with ICU mortality in Côte d'Ivoire. This is a retrospective, observational, single-center study conducted from January 2020 to December 2022. All patients admitted to the ICU for acute poisoning were included. Sociodemographic, clinical, toxicological, and emergency management data were analyzed using Microsoft Excel 2016 (Microsoft Corp., Redmond, WA) and Epi Info 7.2 (CDC, Atlanta, GA). Chi-square or Fisher's exact tests were used (significance threshold: p < 0.05). Of 944 ICU admissions, 296 (31.4%) were for acute poisoning; 200 were analyzed after excluding incomplete records. All patients were initially assessed in the hospital emergency department before ICU transfer. The mean age was 17.4 ± 15.1 years; 53% were female; 48% were under 15 years. Voluntary ingestion accounted for 55% of cases. Caustic substances (48%), organophosphates (17%), and medications (14%) were the most common agents. The overall ICU mortality was 16%. Factors significantly associated with ICU death included age under 15 years (p = 0.005), petroleum product exposure (odds ratio (OR): 3.90 (1.37-11.10); p = 0.005), seizures (OR: 12.06 (5.37-27.26); p < 0.001), respiratory distress (OR: 2.37 (1.18-4.77); p = 0.043), cardiovascular collapse (OR: 6.09 (3.27-10.96); p < 0.001), and dehydration (OR: 26.35 (8.26-106.33); p < 0.001). Additional factors associated with death included delayed ED presentation (≥24 hours: OR: 14.40 (2.43-85.33); p = 0.004) and prehospital oil-based emetic use (OR: 2.08 (1.02-4.24); p = 0.04). Acute poisoning predominantly affects children and young adults. Early triage in the ED, recognition of severity signs, and prompt referral are critical to improving outcomes. These findings have direct implications for emergency medicine practice in resource-limited settings.
-
7. Concurrent Catastrophic Antiphospholipid Syndrome, Hemophagocytic Lymphohistiocytosis, and Myocarditis Leading to Multi-organ Failure in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome.
PMID:日期:2026-09-01Catastrophic antiphospholipid syndrome (CAPS) is a fulminant and life-threatening manifestation of antiphospholipid syndrome (APLS), often presenting with rapid multi-organ dysfunction and high mortality despite aggressive therapy. Its associations with hemophagocytic lymphohistiocytosis (HLH) and lupus myocarditis are not well understood. We report the case of a 43-year-old woman with systemic lupus erythematosus (SLE) and secondary APLS who developed CAPS following elective mitral valve repair. Her course was complicated by renal cortical necrosis, recurrent lupus myocarditis, refractory immune thrombocytopenia, sepsis, and HLH, requiring multiple immunosuppressive modalities including corticosteroids, intravenous immunoglobulin, plasma exchange, rituximab, cyclophosphamide, and anakinra. Despite intensive multidisciplinary management across rheumatology, cardiology, nephrology, hematology, infectious diseases, and intensive care, she suffered progressive multi-organ failure and transitioned to palliative care. This case highlights the diagnostic and therapeutic complexity of overlapping autoimmune syndromes, the risks of surgical triggers in predisposed patients, and the challenges of balancing immunosuppression against infection in the setting of CAPS. It underscores the need for dynamic multidisciplinary collaboration, early recognition of HLH and lupus myocarditis overlap, and timely integration of palliative care when maximal therapy fails.
-
8. Microplastics in Human Ovarian Follicular Fluid and Female Fertility.
PMID:日期:2026-09-01Microplastics and nanoplastics are increasingly reported in human biological matrices, raising concern about the exposure of the ovarian follicle during oocyte maturation. This narrative review evaluated evidence on plastic particles or polymer mass in human ovarian follicular fluid and their potential relevance to female fertility and assisted reproductive technology (ART). PubMed, including the Medical Literature Analysis and Retrieval System Online (MEDLINE); publisher records; reference lists; and citing articles were searched through July 28, 2026. Six full human observational studies and three preliminary reports were identified, demonstrating the limited size of the current evidence base. The full studies detected plastic-derived particles or polymer mass in human follicular fluid, although reported concentrations and polymer profiles differed substantially across analytical platforms. Several small studies associated higher polyethylene (PE) or polyvinyl chloride (PVC) burdens with lower fertilization rates, higher follicle-stimulating hormone (FSH) levels, or diminished ovarian reserve (DOR), while the largest case-control study reported the strongest association for polyamide 66 (PA66). These findings have not been independently replicated and remain observational. Cross-sectional designs, small and selected infertility-clinic populations, residual confounding, possible procedural contamination, nonequivalent measurement units, and the absence of standardized analytical methods preclude causal interpretation and quantitative comparison across studies. Animal and cell studies provide mechanistic plausibility but frequently use exposure conditions that may not represent human follicular exposure. Current evidence therefore supports the presence of plastic-derived material in the human follicular microenvironment but does not establish that microplastics cause infertility or that follicular-fluid testing has clinical utility. Prospective multicenter studies using standardized contamination controls, harmonized exposure measurements, and preregistered reproductive outcomes are required.
-
9. Biomechanical Analysis of Rotator Cuff Repair: Comparison of Sutures and Fixation Techniques in a Synthetic Model.
PMID:日期:2026-09-01Introduction Irreparable rotator cuff tears represent one of the greatest challenges in contemporary orthopedic surgery, imposing significant functional limitation and requiring reconstruction strategies with high mechanical fixation strength. The choice between different suture materials and anchoring techniques directly influences the initial biomechanical stability of the repair, determining construct safety during the critical period of biological healing. Objective To evaluate and compare the load-to-failure of four tendon repair configurations in humeral head synthetic models (Sawbones®; Pacific Research Laboratories, Inc., Vashon, WA, USA), combining two surgical sutures - Ethibond® USP 5 (Ethicon Inc., Raritan, NJ, USA; braided polyester) and FiberWire® USP 2 (Arthrex Inc., Naples, FL, USA; ultra-high-molecular-weight polyethylene) - with two fixation techniques: double metal anchor and transosseous tunnel. Methods Linear tensile mechanical tests to failure were performed on 20 shoulder models, with five samples per experimental group. The tendon was simulated using synthetic leather strips (corino), secured with a five-pass epitendinous running suture. Maximum load to failure was measured with a calibrated dynamometer in kilogram-force (kgf) and converted to Newtons (N). Inclusion criteria restricted the analysis to failures exclusive to the suture material, excluding any structural construct failure. Results All configurations exceeded the 200 N biomechanical threshold considered safe for early rehabilitation. The Ethibond® transosseous tunnel group showed the highest mean strength (357.55 N; SD ± 46.7), followed by FiberWire® with double anchor (330.88 N; SD ± 18.3), transosseous FiberWire® (296.36 N; SD ± 8.6), and Ethibond® with double anchor (293.41 N; SD ± 43.9). Between-group Welch's t-tests showed a trend toward higher strength for the Ethibond® transosseous configuration versus Ethibond® double anchor (p = 0.056), and a significant difference between FiberWire® double anchor and FiberWire® transosseous (p = 0.010); pooled main effects of suture material and fixation technique alone were not significant, suggesting an interaction between suture caliber and fixation geometry. Conclusion In this synthetic model, the transosseous technique combined with high-caliber polyester suture produced the greatest mean mechanical strength, although the advantage over anchor fixation did not reach statistical significance. Surgeons may achieve biomechanically safe and cost-effective fixation using transosseous tunnels with Ethibond® USP 5, reserving anchors and FiberWire® for cases in which tear geometry precludes tunnel creation.
-
10. Radiological Correlates of Headache and Papilledema in Patients Undergoing Cranial MRI: Clinical Relevance of the Evans Index and Fazekas Score.
PMID:日期:2026-09-01The Evans index and Fazekas score are among the most frequently reported incidental findings on cranial magnetic resonance imaging (MRI), yet their relationship with confirmed headache and papilledema is not well characterized outside the normal pressure hydrocephalus (NPH) literature. In this exploratory, hypothesis-generating study, we evaluated this association in patients undergoing cranial MRI for headache and/or visual disturbance. In this retrospective study, cranial MRI of 224 patients (two non-overlapping cohorts, n=100 and n=124) was evaluated by one of two radiologists, who graded the Fazekas score and Evans index. Headache severity (0-3) and papilledema (present/absent) were obtained from clinical records. Associations were assessed with chi-square, Mann-Whitney U, Spearman correlation, and multivariable logistic regression adjusted for age and sex; a sensitivity analysis additionally adjusted for the collinear reader/cohort variable. Papilledema was present in 47 patients (21.0%). The Evans index was independently associated with papilledema (adjusted OR 2.07/0.05-unit increase, 95% CI 1.27-3.33, p=0.004) and headache (adjusted OR 1.52, 95% CI 1.01-2.25, p=0.047); the Fazekas score showed no independent association with either. The papilledema association was non-significant on univariate testing (p=0.206). After adjusting for reader/cohort, the papilledema association strengthened (adjusted OR 2.76, 95% CI 1.59-4.80, p<0.001), while the headache association was attenuated (adjusted OR 1.37, 95% CI 0.89-2.09, p=0.148). The Evans index, but not the Fazekas score, was associated with papilledema across all adjusted models, an association that persisted after adjustment for demographic and cohort variables, although reader identity and cohort membership could not be fully disentangled in this design. Its association with headache was weaker, driven largely by between-cohort differences. Papilledema was recorded as a binary clinical finding without standardized Frisén-scale grading or optical coherence tomography confirmation. These exploratory findings suggest the Evans index may warrant further prospective study beyond NPH, rather than establishing it as a validated marker of intracranial pressure.