星形胶质细胞锚蛋白-2使小鼠海马中的记忆得以持久保存
Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.
摘要(中文译文)
记忆持久性，即随时间保持信息的能力，是长期记忆的基本特征。尽管星形胶质细胞参与突触可塑性，但其支持记忆持久性的分子机制尚不清楚。本研究表明，星形胶质细胞锚蛋白-2（Ank2）是成年小鼠记忆持久性所必需的。星形胶质细胞特异性敲除Ank2损害了远期记忆而不影响近期记忆，并破坏了长时程增强的维持。Ank2缺失减少了星形胶质细胞与印迹神经元的接触，并损害了由脑源性神经营养因子（BDNF）信号通过截短型原肌球蛋白受体激酶B受体（TrkB.T1）和2型肌醇1,4,5-三磷酸受体（IP3R2）驱动的星形胶质细胞形态发生。与这一机制一致，星形胶质细胞Ank2是海马BDNF输注增强记忆持久性所必需的。此外，选择性光遗传学激活星形胶质细胞TrkB.T1信号增强了远期记忆，证明星形胶质细胞BDNF信号足以促进记忆持久性。这些发现确定了星形胶质细胞Ank2是长期记忆持久性的关键调控因子。
Abstract
Memory persistence, the ability to retain information over time, is a fundamental feature of long-term memory. Although astrocytes contribute to synaptic plasticity, the molecular mechanisms by which they support memory persistence remain unclear. Here we show that astrocytic ankyrin-2 (Ank2) is required for memory persistence in adult mice. Astrocyte-specific deletion of Ank2 impaired remote memory without affecting recent memory and disrupted the maintenance of long-term potentiation. Loss of Ank2 reduced astrocyte contacts with engram neurons and impaired astrocyte morphogenesis driven by brain-derived neurotrophic factor (BDNF) signaling through the truncated tropomyosin receptor kinase B receptor (TrkB.T1) and inositol 1,4,5-trisphosphate receptor type 2 (IP3R2). Consistent with this mechanism, astrocytic Ank2 was required for the enhancement of memory persistence by hippocampal BDNF infusion. Furthermore, selective optogenetic activation of astrocytic TrkB.T1 signaling enhanced remote memory, demonstrating that astrocytic BDNF signaling is sufficient to promote memory persistence. These findings identify astrocytic Ank2 as a key regulator of long-term memory persistence.
如何引用
AMA
Hayoung Kim, Jiwoon Lim, Jooyoung Kim, Erva Ozkan, Gyu Hyun Kim, HyoJin Park, et al. Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.. Nature communications. 2026; doi:10.1038/s41467-026-75009-5.
APA
Hayoung Kim, Jiwoon Lim, Jooyoung Kim, Erva Ozkan, Gyu Hyun Kim, HyoJin Park, et al (2026). Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.. Nature communications. https://doi.org/10.1038/s41467-026-75009-5
GB/T 7714
Hayoung Kim, Jiwoon Lim, Jooyoung Kim, Erva Ozkan, Gyu Hyun Kim, HyoJin Park, et al. Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.[J]. Nature communications, 2026 doi:10.1038/s41467-026-75009-5.
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