Nature Communications自然·通讯
Nature Communications(英文缩写 NAT COMMUN),ISSN 2041-1723,eISSN 2041-1723,中文译名:自然·通讯 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
Nature Communications 最新收录文献
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1. Model-free pattern separation of two-color ultrafast X-ray diffraction.
1. 双色超快X射线衍射的无模型图样分离PMID:日期:2026-09-03Two-color X-ray imaging with Free Electron Laser pulses offers a powerful approach for probing ultrafast structural dynamics in nanoscale systems, combining (near-)atomic spatial resolution with femtosecond temporal precision. The first X-ray pulse captures the object's initial state, while the second, time-delayed pulse records its subsequent evolution. A key challenge lies in disentangling the two patterns simultaneously recorded by the same detector. We demonstrate the realization of this approach on structurally varying nanoscale particles using two X-ray pulses of different photon energies, 1 and 1.2 keV. Sub-micrometer helium nanodroplets generated in vacuum are irradiated by the two X-ray pulses separated in time by up to 750 femtoseconds. Taking advantage of the high photon-energy resolution of the imaging detector, we separate the overlapping diffraction signals by analyzing individual pixel counts and applying pattern recognition. The helium nanodroplets' spherical shape allows us to cross-validate this approach by fitting the radial scattering profiles with Mie solutions for abichromatic field. The excellent agreement between the two methods, particularly in the sparsely illuminated outer regions of the diffraction patterns where high-resolution structural information is encoded, highlights the quality of this approach and its potential for future advanced X-ray movie techniques.
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2. High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions.
PMID:日期:2026-09-03Endosomal NHE6 (SLC9A6) and NHE9 (SLC9A9) transporters are essential for maintaining pH homeostasis within endosomes and their dysfunction has been linked to neurological and neurodegenerative disorders. NHE6 and NHE9 are widely considered to function as electroneutral exchangers that couple the export of protons to the import of sodium or potassium ions across cellular membranes, thereby forming the basis of proton leak pathways for internal pH balancing and fine-tuning. Among the 13 identified SLC9 family members, only NHE6 and NHE9 are targeted to endosomes. Despite their biological importance and therapeutic potential, the structural basis for their activity and regulation remains elusive. Here, we present the cryo-EM structures of human NHE9 and two splice variants of NHE6 that differ by alternative inclusion of the β-hairpin motif-containing loop domain located between transmembrane helices 2 and 3, showcasing structural diversity within the organellar NHE subfamily. By mapping the sodium-binding site, our results provide mechanistic insights into ion transport, and for NHE6 we provide evidence for a conserved PIP2-mediated regulatory mechanism. These findings provide a framework for understanding endosomal NHE function with implications for disorders such as Alzheimer's disease and glioblastoma.
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3. Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1.
PMID:日期:2026-09-03Statin therapies, used to lower high blood cholesterol, have been proposed to cause skeletal muscle side effects including myalgia and rhabdomyolysis. The ryanodine receptor 1 (RyR1)/Ca²⁺ release channel in skeletal muscle has recently been identified as an off-target binder of statins. Here, we report the cryo-electron microscopy structure of RyR1 in complex with rosuvastatin. Rosuvastatin occupies a single binding site in the pore region of RyR1 stabilizing the open conformation. In the closed conformation, the rosuvastatin binding site is occupied by the RyR1 auxiliary transmembrane helices (TMx1-2). Structural comparison indicates steric overlap of rosuvastatin with simvastatin (at Sim-1) but not with atorvastatin on RyR1, while all these statins may interfere with the conformational stability of the TMx1-2 helices. In contrast to simvastatin and atorvastatin, rosuvastatin does not exhibit multiple binding sites on RyR1 while similarly promoting RyR1 activation, indicating its potential as a preferable lead structure for developing statins that minimizes adverse side effects on RyR1.
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4. Motifs of brain cortical folding from birth to adulthood.
4. 从出生到成年期大脑皮层褶皱的基序PMID:日期:2026-09-03Cortical folding of the brain is widely regarded as an interplay between genetic programming and biomechanical forces, closely linked to cytoarchitectonic regionalisation. Abnormal folding patterns are frequently observed in neurodevelopmental conditions and psychiatric disorders. However, significant inter-individual variability of secondary and tertiary folds obscures the detection of shape biomarkers and confounds the investigation of folding-functional relationships. Here, we investigate cortical folding heterogeneity at a fine scale, using Multimodal Surface Matching with Hierarchical Templates (MSM-HT), a hierarchical surface registration, to parse cortical folding patterns into a representative family of distinct anatomical templates. By applying this technique both to young adults from the Human Connectome Project (HCP) and neonates in the Developing HCP and Brain Imaging in Babies (BIBS) cohorts, we identify and characterise common lobe-wise folding patterns: observing consistency across both age groups, with neonatal samples showing less variation. Crucially, we highlight significant hemispheric asymmetry within the temporal lobe in adults, with a consistent trend in neonates. This study provides a critical step towards understanding brain asymmetry and complex relationships between folding and function, offering a robust framework to generalise the uncovered cortical folding motifs across datasets and developmental stages.
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5. Heterogeneity in the response to the metabolic environment drives fosfomycin heteroresistance.
PMID:日期:2026-09-03Heteroresistance is a form of antibiotic resistance in which a phenotypically unstable subpopulation of resistant cells coexists with a majority susceptible population. Many mechanisms of heteroresistance are unclear and the impact of the extracellular environment on this phenomenon is unknown. Studying fosfomycin heteroresistance in Enterobacter cloacae complex, we observed that glucose availability greatly increased the frequency of the resistant subpopulation. Glucose downregulated the glycerol and fosfomycin importer GlpT via catabolite repression. Heteroresistance was generated by heterogeneity in single-cell expression of GlpT, in addition to expression of fosA, which acted as a resistance enhancer. Due to the impact of environmental glucose on glpT expression, we observed that the resistant subpopulation was more frequent during infection in murine models of hyperglycemia/diabetes. Thus, we reveal a paradigm where heterogeneity in response to the environment tunes resistant subpopulation frequency, which suggests that the metabolic context of infection in specific disease states may be important to consider in treatment decisions.
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6. Paleogeographic controls on Phanerozoic weathering rates and implications for climate regulation.
PMID:日期:2026-09-03Earth's climate has remained habitable for billions of years, a stability usually attributed to a negative feedback from silicate weathering - the chemical breakdown of silicate rocks on land, which consumes atmospheric carbon dioxide faster as climate warms. However, whether temperature or hydrology primarily drives this feedback remains uncertain. Here we show the two controls leave geographic fingerprints: in an ensemble of climate simulations with randomized continents, temperature-controlled weathering depends on tropical land fraction, whereas hydrology-controlled weathering depends on continental fragmentation. Stronger weathering removes more carbon dioxide, cooling the planet, so each regime predicts anti-correlation between temperature and its controlling geography. Reconstructed global temperatures spanning 480 million years are anti-correlated with tropical land fraction, except from roughly 295 to 200 million years ago - overlapping the supercontinent Pangea - when they anti-correlate with continental fragmentation. The mechanism stabilizing Earth's climate may thus have evolved, with temperature control apparently dominant for most of this period.
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7. Suppressing Polyamide Crystallization Unlocks Ultrapermeable and Highly Selective Nanofiltration Membranes.
PMID:日期:2026-09-03Nanofiltration (NF) membranes are essential for water purification. However, their performance is still largely optimized through empirical methods, as polyamide crystallinity remain difficult to control in scalable interfacial polymerization processes. In this study, we introduce an ultra-low-temperature interfacial polymerization strategy at -20 °C that enables direct polyamide chain assembly, suppresses crystallization, and forms a smooth, defect-free, fully amorphous selective layer. Comprehensive characterization confirms the formation of a homogeneous amorphous network, enabling a fourfold increase in water permeability and a threefold improvement in Cl/SO selectivity compared with room-temperature controls, surpassing high-performance NF membranes. The smooth surface further improves the antifouling performance of the NF membrane. Life cycle assessment based on experiments with real industrial wastewater, demonstrate that using the fabricated membrane can reduce treatment costs by 79.1%. This work establishes temperature-controlled chain assembly as a scalable lever for NF design and provides a practical pathway toward next-generation membranes for water treatment.
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8. Multi-stage single-cell atlas of a chordate non-embryonic development unveils dedifferentiating bud founder cells.
8. 脊索动物非胚胎发育的多阶段单细胞图谱揭示了去分化的芽基奠基细胞PMID:日期:2026-09-03Colonial tunicates are the only chordates capable of forming fully functional bodies from somatic tissues through non-embryonic development, or budding. In Botryllus schlosseri, budding produces new individuals (zooids) from a portion of the peribranchial epithelium of a preexisting zooid. While the anatomy of this process has been described in detail, the cellular and molecular mechanisms underpinning bud initiation remain elusive. Here, we present a multi-stage single-cell transcriptomic atlas of a non-embryonic development in a chordate, capturing initiation and development of zooids. We identify an epithelial founder cell population that gains developmental potential through possible dedifferentiation, challenging the long-standing hypothesis that a long-lived, circulating pluripotent stem cell drives new zooid formation. Although some circulating cells exhibit stem-like expression profiles, these populations are either hematopoietic or germline restricted lineages. This atlas provides a foundational resource for understanding the cellular origin and mechanisms underlying agametic development and possibly whole-body regeneration in chordates.
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9. PIP2 binding at allosteric site blocks activation in human rod CNG channels.
PMID:日期:2026-09-03Phosphatidylinositol-4,5-bisphosphate (PIP2) is a signaling lipid that regulates multiple ion channels. In rod cyclic nucleotide-gated (CNG) channels, PIP2 was reported to inhibit activity, controlling light sensitivity and dynamic range. Reports of low PIP2 levels in rod outer segment (ROS) membranes questioned the physiological relevance of such inhibition, and the underlying mechanism remained unclear. Here we define the mechanism of PIP2 inhibition of human CNGA1, the principal rod CNG channel subunit. Flux assays and single-channel electrophysiology of purified, liposome-reconstituted CNGA1 channels demonstrate inhibition at PIP2 concentrations estimated for ROS membranes. Cryo-EM structures of PIP2-free channels in lipid nanodiscs capture closed, intermediate, and open conformations, whereas the open state is absent with PIP2. PIP2 binds at the interface between voltage-sensing, pore, and C-linker domains, stabilizing closed states and sterically preventing channel opening. Our findings establish the physiological relevance and structural mechanism of PIP2 inhibition, and provide an inhibitory allosteric site for therapeutic targeting.
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10. {"_":"Increased encoding of aversive stimuli by lateral habenula neurons during Δ-tetrahydrocannabinol withdrawal.","sup":["9"]}
PMID:日期:2026-09-03The lateral habenula (LHb) integrates cortical and basal forebrain (BF) input and is implicated in negative affective states, but its involvement in negative affect associated with cannabis withdrawal is unknown. Here, effects of withdrawal from the psychoactive cannabis constituent, Δ-tetrahydrocannabinol (Δ-THC), on fear conditioning (FC) and LHb function were measured in rats using calcium photometry and electrophysiology. FC-associated LHb calcium signals, freezing behavior, and LHb excitatory-inhibitory (E-I) ratios were increased during Δ-THC withdrawal, and local GABA release was impaired, indicating disinhibition of LHb output neurons. GABA release was also impaired at optogenetically activated BF-LHb axons, and not from ventral tegmental area-LHb inputs. The results indicate that Δ-THC withdrawal increases LHb excitability through disinhibition, contributing to increased fear of primary and conditioned aversive stimuli. Our findings implicate the LHb in cannabis withdrawal-associated negative affect and offer insight into the neural mechanisms of cannabis use disorder.