可转位元件通过细胞类型特异性表观基因组关联影响人类调控格局
Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations.
摘要(中文译文)
转座元件（TEs）是能够在基因组内产生自身拷贝的DNA序列。研究表明，转座元件可作为顺式调控元件并在人类基因组中被招募利用。因此，其影响可能源于与表观基因组的关系。然而，目前仍缺乏一项系统性分析，将转座元件与人类各细胞类型中的染色质组蛋白修饰相关联。本研究利用国际人类表观基因组联盟提供的数据集，该数据集包含47种细胞类型中6种组蛋白修饰的4867项统一处理的ChIP-seq实验，结果显示转座元件在不同组蛋白修饰中具有显著不同的富集水平。我们发现转座元件总体呈耗竭状态，但在特定情境下富集，例如L1元件在H3K9me3组蛋白修饰中的富集。值得注意的是，我们鉴定出456个具有强烈细胞类型特异性富集的细胞类型-组蛋白-转座元件三元组，并表明其中许多三元组与相关生物学过程相关联。
Abstract
Transposable elements (TEs) are DNA sequences able to create copies of themselves within the genome. TEs have been shown to act as cis-regulatory elements and be co-opted in the human genome. Thus, their impact might come from their relationship with the epigenome. However, a systematic analysis that relates TEs with chromatin histone marks across human cell types remains lacking. Here we leverage a dataset from the International Human Epigenome Consortium featuring 4867 uniformly processed ChIP-seq experiments for 6 histone marks across 47 cell types and show that TEs have drastically different enrichments levels across histone marks. We find that TEs are generally depleted but enriched in select contexts such as L1s in H3K9me3 histone mark. Notably, we identify 456 cell type-histone-TE triplets with strong cell-type specific enrichments and show that many of these triplets are associated with relevant biological processes.
如何引用
AMA
Jeffrey Hyacinthe, Guillaume Bourque. Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations.. Nature communications. 2026; doi:10.1038/s41467-026-74920-1.
APA
Jeffrey Hyacinthe, Guillaume Bourque (2026). Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations.. Nature communications. https://doi.org/10.1038/s41467-026-74920-1
GB/T 7714
Jeffrey Hyacinthe, Guillaume Bourque. Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations.[J]. Nature communications, 2026 doi:10.1038/s41467-026-74920-1.
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