设计体外模型以复制慢性伤口的复杂性
Engineering in vitro models to replicate the complexity of chronic wounds.
摘要(中文译文)
慢性创面是一个重大的临床挑战，其驱动因素包括持续性炎症、蛋白水解失衡、微生物定植以及组织再生受损。本综述批判性地审视了慢性创面研究中使用的二维和三维体外模型，评估其在静脉性腿部溃疡、糖尿病足溃疡和压力性溃疡中再现慢性化特征的能力。当前系统缺乏再现不愈合表型关键特征所需的生化复杂性。基于定量临床创面渗出液数据，我们提出了一个以特征为驱动、按病因分层的框架，为体外模型和慢性创面模拟培养基提供模块化设计考量。
Abstract
Chronic wounds represent a major clinical challenge driven by sustained inflammation, proteolytic imbalance, microbial colonisation, and impaired tissue regeneration. This review critically examines 2D and 3D in vitro models used in chronic wound research, evaluating their capacity to recapitulate chronicity across venous leg ulcers, diabetic foot ulcers, and pressure ulcers. Current systems lack the biochemical complexity required to reproduce key features of the non-healing phenotype. Building on quantitative clinical wound exudate data, we propose a feature-driven, aetiology-stratified framework that provides modular design considerations for in vitro models and chronic wound simulating media.
如何引用
AMA
Lucas Argandoña, Kristina Ivanova, Tzanko Tzanov. Engineering in vitro models to replicate the complexity of chronic wounds.. Nature communications. 2026; doi:10.1038/s41467-026-75311-2.
APA
Lucas Argandoña, Kristina Ivanova, Tzanko Tzanov (2026). Engineering in vitro models to replicate the complexity of chronic wounds.. Nature communications. https://doi.org/10.1038/s41467-026-75311-2
GB/T 7714
Lucas Argandoña, Kristina Ivanova, Tzanko Tzanov. Engineering in vitro models to replicate the complexity of chronic wounds.[J]. Nature communications, 2026 doi:10.1038/s41467-026-75311-2.
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