Clinical Outcomes of Once-Weekly Hypofractionated Intensity-Modulated Radiation Therapy with Concurrent α-Sulfoquinovosyl-Acylpropanediol for Modified Adams Stage 4 Canine Intranasal Tumors: A Retrospective Case Series.
我们描述了接受每周一次大分割放射治疗（RT）联合放射增敏剂α-磺基喹诺糖基酰基丙二醇（SQAP）治疗的改良Adams 4期鼻腔肿瘤犬的肿瘤反应和生存情况，并比较了线性与体积学反应评估。本回顾性病例系列纳入20只接受调强放疗（每次8 Gy，每周一次）并同期给予SQAP的犬。通过增强计算机断层扫描，采用类RECIST线性测量和体积分析评估肿瘤反应。采用Kaplan-Meier分析估计总生存期（OS）。20只犬中，4只归类为4a期，16只归类为4b期。最佳类RECIST反应为完全缓解（CR）5只、部分缓解（PR）12只、疾病稳定（SD）4只。体积学反应为CR 5只、PR 11只、SD 5只。无病例的最佳反应为疾病进展。所有犬的中位OS为342天（95%置信区间[CI]，206-419天）。剔除1例非肿瘤相关死亡后，中位OS为356天（95% CI，231-419天）。探索性分析显示，4a期和4b期犬的中位OS分别为393天和297天。在部分病例中，体积学评估似乎对检测肿瘤再生长更为敏感。皮肤不良事件仅限于放射野内脱毛，未观察到完全视力丧失。8只犬记录到癫痫发作活动。总之，每周一次大分割调强放疗联合同期SQAP与晚期鼻腔肿瘤犬具有临床意义的生存结局相关。然而，由于缺乏单纯放疗对照组，无法确定SQAP对这些结局的独立贡献。
We described tumor response and survival in dogs with modified Adams stage 4 intranasal tumors treated with once-weekly hypofractionated radiation therapy (RT) combined with the radiosensitizer α-sulfoquinovosyl-acylpropanediol (SQAP), and compared linear and volumetric response assessments. Twenty dogs treated with intensity-modulated RT (8 Gy per fraction, once weekly) and concurrent SQAP were included in this retrospective case series. Tumor response was assessed using RECIST-like linear measurements and volumetric analysis on contrast-enhanced computed tomography. Overall survival (OS) was estimated using Kaplan-Meier analysis. Of the 20 dogs, 4 were classified as stage 4a and 16 as stage 4b. The best RECIST-like responses were complete response (CR) in 5 dogs, partial response (PR) in 12, and stable disease (SD) in 4. Volumetric responses were CR in 5 dogs, PR in 11, and SD in 5. No cases demonstrated progressive disease as the best response. The median OS for all dogs was 342 days (95% confidence interval [CI], 206-419 days). Censoring one non-tumor-related death yielded a median OS of 356 days (95% CI, 231-419 days). Exploratory analysis revealed median OS of 393 and 297 days for stage 4a and 4b dogs, respectively. Volumetric assessment appeared more sensitive for detecting tumor regrowth in selected cases. Dermatologic adverse events were limited to alopecia within the radiation field, and no complete vision loss was observed. Seizure activity was documented in eight dogs. In conclusion, once-weekly hypofractionated intensity-modulated RT combined with concurrent SQAP was associated with clinically meaningful survival outcomes in dogs with advanced intranasal tumors. However, because no radiotherapy-alone control group was available, the independent contribution of SQAP to these outcomes could not be determined.
Akihiro Ohnishi, Yuko Mizutani, Saki Kageyama, Shinya Mizutani, Taketoshi Asanuma. Clinical Outcomes of Once-Weekly Hypofractionated Intensity-Modulated Radiation Therapy with Concurrent α-Sulfoquinovosyl-Acylpropanediol for Modified Adams Stage 4 Canine Intranasal Tumors: A Retrospective Case Series.. Veterinary sciences. 2026; doi:10.3390/vetsci13060601.
Akihiro Ohnishi, Yuko Mizutani, Saki Kageyama, Shinya Mizutani, Taketoshi Asanuma (2026). Clinical Outcomes of Once-Weekly Hypofractionated Intensity-Modulated Radiation Therapy with Concurrent α-Sulfoquinovosyl-Acylpropanediol for Modified Adams Stage 4 Canine Intranasal Tumors: A Retrospective Case Series.. Veterinary sciences. https://doi.org/10.3390/vetsci13060601
Akihiro Ohnishi, Yuko Mizutani, Saki Kageyama, Shinya Mizutani, Taketoshi Asanuma. Clinical Outcomes of Once-Weekly Hypofractionated Intensity-Modulated Radiation Therapy with Concurrent α-Sulfoquinovosyl-Acylpropanediol for Modified Adams Stage 4 Canine Intranasal Tumors: A Retrospective Case Series.[J]. Veterinary sciences, 2026 doi:10.3390/vetsci13060601.
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