超声引导下的坐骨神经和隐神经阻滞可增强实验性骨科后肢手术绵羊的围手术期镇痛
Ultrasound-Guided Sciatic and Saphenous Nerve Blocks Enhance Perioperative Analgesia in Sheep Undergoing Experimental Orthopaedic Hindlimb Surgery.
摘要(中文译文)
由于伦理考量以及改善围手术期稳定性的需要，绵羊实验外科对精细化麻醉方案的需求日益增加。本研究评估了在加那利毛羊接受侵入性后肢骨科手术时，采用两种不同局部麻醉药进行超声引导下坐骨神经与隐神经联合阻滞的镇痛效果。十五只临床健康绵羊被随机分配至三组：利多卡因（2%）、布比卡因（0.5%）或对照组（仅全身麻醉）。记录术中生理参数，包括心率、呼吸频率和动脉血压，并使用改良墨尔本疼痛量表评估术后疼痛。接受局部区域麻醉的绵羊术后疼痛评分显著低于对照组动物。术中，仅呼吸频率在组间存在显著差异，布比卡因组数值较低。布比卡因组表现出更低且更稳定的呼吸频率，术中心率呈降低趋势，术后早期疼痛评分也持续较低。与对照组相比，利多卡因的术中及术后效果有限。呼吸频率似乎比其他生理参数与疼痛评分的关系更为密切。总之，超声引导下坐骨神经与隐神经阻滞与接受骨科手术绵羊围手术期镇痛效果的改善相关。使用布比卡因与术中较低的呼吸频率及术后疼痛评分降低相关，提示其在围手术期镇痛中具有潜在益处。
Abstract
The demand for refined anaesthetic protocols in ovine experimental surgery has increased due to ethical considerations and the need to improve perioperative stability. This study evaluated the analgesic efficacy of ultrasound-guided combined sciatic and saphenous nerve blocks using two different local anaesthetics in Hair Canarian Sheep undergoing invasive orthopaedic hindlimb surgery. Fifteen clinically healthy sheep were randomly assigned to one of three groups: lidocaine (2%), bupivacaine (0.5%), or control (general anaesthesia alone). Intraoperative physiological parameters, including heart rate, respiratory rate, and arterial blood pressure, were recorded, and postoperative pain was assessed using a modified Melbourne Pain Scale. Sheep receiving locoregional anaesthesia showed significantly lower postoperative pain scores compared with control animals. Intraoperatively, a significant difference between groups was observed only for respiratory rate, with lower values in the bupivacaine group. The bupivacaine group exhibited lower and more stable respiratory rates, with a trend towards lower heart rates during surgery, as well as consistently lower pain scores during the early postoperative period. Lidocaine provided limited intraoperative and postoperative effects compared with the control group. Respiratory rate appeared to be more closely associated with pain scores than other physiological parameters. In conclusion, ultrasound-guided sciatic and saphenous nerve blocks were associated with improved perioperative analgesia in sheep undergoing orthopaedic surgery. The use of bupivacaine was associated with lower respiratory rates intraoperatively and reduced postoperative pain scores, suggesting a potential benefit in perioperative analgesia.
如何引用
AMA
Oliver Rodriguez, Pedro Figueirinhas, Daniela Vazquez, Sara Del-Rosario, Yeray Brito-Casillas, Sergio Martin, et al. Ultrasound-Guided Sciatic and Saphenous Nerve Blocks Enhance Perioperative Analgesia in Sheep Undergoing Experimental Orthopaedic Hindlimb Surgery.. Veterinary sciences. 2026; doi:10.3390/vetsci13040318.
APA
Oliver Rodriguez, Pedro Figueirinhas, Daniela Vazquez, Sara Del-Rosario, Yeray Brito-Casillas, Sergio Martin, et al (2026). Ultrasound-Guided Sciatic and Saphenous Nerve Blocks Enhance Perioperative Analgesia in Sheep Undergoing Experimental Orthopaedic Hindlimb Surgery.. Veterinary sciences. https://doi.org/10.3390/vetsci13040318
GB/T 7714
Oliver Rodriguez, Pedro Figueirinhas, Daniela Vazquez, Sara Del-Rosario, Yeray Brito-Casillas, Sergio Martin, et al. Ultrasound-Guided Sciatic and Saphenous Nerve Blocks Enhance Perioperative Analgesia in Sheep Undergoing Experimental Orthopaedic Hindlimb Surgery.[J]. Veterinary sciences, 2026 doi:10.3390/vetsci13040318.
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