运动对氟中毒的影响：综合多系统综述
The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.
摘要(中文译文)
氟中毒是一种由长期过量摄入氟化物引起的全身性疾病，对全球牲畜健康和农业生产构成重大威胁。本系统综述综合了关于运动对氟中毒调节作用的现有证据，整合了人体研究、动物实验及方法学考量。人体研究表明，氟暴露与认知发育、肌肉功能和运动能力之间存在负相关，且运动以运动强度依赖的方式影响氟化物的药代动力学。动物实验一致表明，规律的中等强度运动可通过激活Nrf2/ARE抗氧化通路、调节BMP-2/Smads和OPG/RANKL/RANK信号传导、抑制炎症反应以及维持肠道屏障完整性，减轻氟化物引起的多器官系统损伤。当前氟中毒模型在暴露剂量、暴露时长和运动方案方面存在显著异质性，凸显了标准化及考虑遗传背景的必要性。总体而言，运动在减轻氟中毒诱导的多器官损伤方面显示出前景，尽管人体证据仍然有限。未来研究应优先开展模型优化、阐明分子靶点以及探索协同干预措施，为兽医临床管理提供基础。
Abstract
Fluorosis, a systemic condition caused by chronic excessive fluoride intake, poses significant threats to livestock health and agricultural productivity worldwide. This systematic review synthesizes current evidence on the modulatory effects of exercise against fluorosis, integrating human studies, animal experiments, and methodological considerations. Human studies indicate negative associations between fluoride exposure and cognitive development, muscle function, and exercise capacity, with exercise influencing fluoride pharmacokinetics in an exercise-intensity-dependent manner. Animal experiments consistently demonstrate that regular moderate-intensity exercise attenuates fluoride-induced damage across multiple organ systems through activation of the Nrf2/ARE antioxidant pathway, modulation of BMP-2/Smads and OPG/RANKL/RANK signaling, suppression of inflammatory responses, and preservation of intestinal barrier integrity. Substantial heterogeneity exists among current fluorosis models regarding exposure dosages, durations, and exercise protocols, underscoring the need for standardization and consideration of genetic background. Overall, exercise shows promise for mitigating fluorosis-induced multi-organ damage, although human evidence remains limited. Future research should prioritize model optimization, elucidation of molecular targets, and exploration of synergistic interventions to provide a foundation for veterinary clinical management.
如何引用
AMA
Fengge Han, Xiaohui Li, Sheraz Ahmad, Qi Lei, Zilong Sun. The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.. Veterinary sciences. 2026; doi:10.3390/vetsci13050446.
APA
Fengge Han, Xiaohui Li, Sheraz Ahmad, Qi Lei, Zilong Sun (2026). The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.. Veterinary sciences. https://doi.org/10.3390/vetsci13050446
GB/T 7714
Fengge Han, Xiaohui Li, Sheraz Ahmad, Qi Lei, Zilong Sun. The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.[J]. Veterinary sciences, 2026 doi:10.3390/vetsci13050446.
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