五匹马远端第三掌骨与近端第一指骨的大体和组织病理学比较及氟化钠正电子发射断层扫描放射性药物摄取
Gross and Histopathologic Comparison of the Distal Third Metacarpal Bone and the Proximal First Phalanx with Sodium Fluoride Positron Emission Tomography Radiopharmaceutical Uptake in Five Horses.
摘要(中文译文)
掌指关节损伤是赛马发病和灾难性骨折的主要原因，然而早期骨性病变往往难以通过传统影像学检查发现。本初步研究旨在探讨氟化钠正电子发射断层扫描（F-NaF PET）放射性药物摄取与第三掌骨远端（MC3）及第一指骨近端（P1）大体病理和组织病理学改变之间的相关性。五匹马（三匹患有球节损伤的赛马纯血马和两匹非赛马对照）生前接受了F-NaF PET和锥形束CT成像（CBCT），随后对预定义解剖部位进行了死后大体和组织学检查。定量PET指标，包括最大标准化摄取值（SUV）、SUV和PET分级，与软骨及软骨下骨的大体病理和组织病理学评分进行了比较。尽管在特定部位PET指标与大体或组织学评分之间存在显著的区域相关性，但鉴于评估的马匹数量较少，我们的结果需谨慎解读。PET指标与大体病理评分之间的相关性在掌骨远端外侧背侧髁以及P1近端外侧背侧和P1中部被识别。PET指标与透明软骨组织病理学评分的相关性见于P1背内侧和外侧、P1背外侧旁矢状面以及MC3内侧旁矢状沟。PET指标与组织学软骨下骨评分的相关性在MC3内侧掌侧髁、内侧旁矢状沟和掌侧外侧旁矢状面具有显著性。对于P1，PET指标与组织学软骨下骨评分在旁矢状面中外侧和背内侧区域显著相关。总体而言，这些发现表明F-NaF PET能够识别与特定球节区域组织学和大致病理相对应的局限性骨重塑，支持其用于检测骨性损伤的效用，尽管这种关系因解剖位置而异。尚需在更大数量的马匹中进一步研究。
Abstract
Injuries of the metacarpophalangeal joint are a major cause of morbidity and catastrophic fracture in racing horses, yet early osseous pathology is often difficult to detect using conventional imaging. This pilot study aimed to correlate sodium fluoride Positron Emission Tomography (F-NaF PET) radiopharmaceutical uptake with gross and histopathologic changes in the distal third metacarpal bone (MC3) and proximal first phalanx (P1). Five horses (three racing Thoroughbreds with fetlock injury and two non-racing controls) underwent ante-mortem F-NaF PET and cone-beam CT imaging (CBCT), followed by post-mortem gross and histologic examination of predefined anatomic sites. Quantitative PET measures, including maximum standardized uptake value (SUV), SUV, and PET grade, were compared with gross pathology and histopathologic scores for cartilage and subchondral bone. While there were significant regional correlations between PET metrics and gross or histologic scores at select sites, our results need to be considered in light of the small number of horses evaluated. Correlations between PET metrics and gross pathology score were identified on the distal metacarpus on the lateral dorsal condyle and on proximal P1 for lateral dorsal and mid-P1. Correlation of PET metrics and hyaline cartilage histopathology scores were found for dorsal medial and lateral P1, parasagittal dorsolateral P1 and the medial parasagittal groove of MC3. Correlation of PET metrics and histologic subchondral bone scores were significant for medial palmar condyle, medial parasagittal groove, and parasagittal palmar lateral of MC3. For P1, PET metrics and histologic subchondral bone scores were significantly correlated for parasagittal mid-lateral and medial dorsal regions. Overall, these findings demonstrate that F-NaF PET identifies localized bone remodeling that corresponds to histologic and gross pathology at specific fetlock regions, supporting its utility for detecting osseous injury, although relationships varied by anatomic location. Further work with larger numbers of horses is needed.
如何引用
AMA
Maureen Kelleher, Jacqueline Marr, Brittney Graham, Thomas Cecere, Brett Klamer, Sergey Anishchenko, et al. Gross and Histopathologic Comparison of the Distal Third Metacarpal Bone and the Proximal First Phalanx with Sodium Fluoride Positron Emission Tomography Radiopharmaceutical Uptake in Five Horses.. Veterinary sciences. 2026; doi:10.3390/vetsci13060591.
APA
Maureen Kelleher, Jacqueline Marr, Brittney Graham, Thomas Cecere, Brett Klamer, Sergey Anishchenko, et al (2026). Gross and Histopathologic Comparison of the Distal Third Metacarpal Bone and the Proximal First Phalanx with Sodium Fluoride Positron Emission Tomography Radiopharmaceutical Uptake in Five Horses.. Veterinary sciences. https://doi.org/10.3390/vetsci13060591
GB/T 7714
Maureen Kelleher, Jacqueline Marr, Brittney Graham, Thomas Cecere, Brett Klamer, Sergey Anishchenko, et al. Gross and Histopathologic Comparison of the Distal Third Metacarpal Bone and the Proximal First Phalanx with Sodium Fluoride Positron Emission Tomography Radiopharmaceutical Uptake in Five Horses.[J]. Veterinary sciences, 2026 doi:10.3390/vetsci13060591.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出