仿生自组装的炮天雄多糖和α-硫辛酸纳米士兵：针对系膜增生性肾小球肾炎的高度特异性靶向治疗
Biomimetic self-assembled nanosoldiers of paotianxiong polysaccharides and α-lipoic acid: Highly specific targeted therapy for mesangial proliferative glomerulonephritis.
摘要(中文译文)
作为慢性肾脏病进展中高度普遍的病症，系膜增生性肾小球肾炎（MsPGN）的治疗选择有限，肾小球屏障在很大程度上限制了药物疗效。活性氧（ROS）、炎症和异常细胞增殖在MsPGN的发病机制中发挥关键作用。为克服传统药物和纳米载体递送系统在MsPGN治疗中的局限性，本研究提出了一种有趣的“药物-载体一体化、协同靶向”策略。我们的初步实验发现，泡天雄多糖（PP）具有抑制系膜细胞（MCs）增殖的作用。开发了将亲水性PP与疏水性α-硫辛酸（LA）结合的新型自组装纳米颗粒。该设计将LA的ROS清除和抗炎功能与PP在诱导MCs凋亡方面的优势相结合，从而协同抑制MCs的异常增殖并同时提高生物利用度。首次采用LPS/PDGF-BB激活的MC膜包覆纳米颗粒进行仿生递送，实现靶向MsPGN治疗。所制备的纳米颗粒（平均粒径：74 nm）在MCs中表现出显著的摄取。在体外，它们表现出抑制MCs增殖、清除ROS和减轻炎症的显著能力。在体内，它们可实现主动和被动靶向的协同效应，并有效蓄积于肾小球MCs中。通过调节氧化应激、抑制M1巨噬细胞极化和抑制生长因子表达的协同作用，它们可有效缓解MsPGN。此外，治疗期间未观察到明显的不良反应。总体而言，本研究构建了一种用于MsPGN治疗的新型自组装纳米制剂，提供了一种靶向肾小球MCs的新颖且有前景的仿生纳米递送策略。
Abstract
As a highly prevalent condition in chronic kidney disease progression, mesangial proliferative glomerulonephritis (MsPGN) has limited therapeutic options, with the glomerular barrier substantially restricting drug efficacy. Reactive oxygen species (ROS), inflammation, and aberrant cellular proliferation play pivotal roles in the pathogenesis of MsPGN. To overcome limitations of conventional drugs and nanocarrier delivery systems in MsPGN treatment, this study proposed an interesting "drug-carrier integration, synergistic targeting' strategy. Our preliminary experiment found that Paotianxiong polysaccharides (PP) has the effect of inhibiting mesangial cells (MCs) proliferation. Novel self-assembling nanoparticles incorporating hydrophilic PP and hydrophobic α-lipoic acid (LA) were developed. This design integrates the ROS scavenging and anti-inflammatory functions of LA with the superiority of PP in inducing MCs apoptosis, thereby synergistically inhibiting the abnormal proliferation of MCs and improving bioavailability simultaneously. For the first time, nanoparticles were coated with LPS/PDGF-BB-activated MC membranes for biomimetic delivery, enabling targeted MsPGN therapy. The prepared nanoparticles (average size: 74 nm) demonstrated significant uptake in MCs. In vitro, they exhibited remarkable capabilities in inhibiting MCs proliferation, scavenging ROS, and reducing inflammation. In vivo, they can achieve the synergistic effect of active and passive targeting and effectively accumulate in glomerular MCs. Through the synergistic effects of regulating oxidative stress, inhibiting M1 macrophage polarization, and suppressing growth factor expression, they can effectively alleviate MsPGN. Furthermore, no significant adverse effects were observed during treatment. Overall, this study constructed a novel self-assembled nanoformulation for MsPGN treatment, provided a new and promising biomimetic nano-delivery strategy targeting glomerular MCs.
如何引用
AMA
Qiao Ren, Xiaoxi Liang, Jiaxin Jiang, Xue Wen, Yi Lin, Quan Zhang, et al. Biomimetic self-assembled nanosoldiers of paotianxiong polysaccharides and α-lipoic acid: Highly specific targeted therapy for mesangial proliferative glomerulonephritis.. Materials today. Bio. 2026; doi:10.1016/j.mtbio.2026.103313.
APA
Qiao Ren, Xiaoxi Liang, Jiaxin Jiang, Xue Wen, Yi Lin, Quan Zhang, et al (2026). Biomimetic self-assembled nanosoldiers of paotianxiong polysaccharides and α-lipoic acid: Highly specific targeted therapy for mesangial proliferative glomerulonephritis.. Materials today. Bio. https://doi.org/10.1016/j.mtbio.2026.103313
GB/T 7714
Qiao Ren, Xiaoxi Liang, Jiaxin Jiang, Xue Wen, Yi Lin, Quan Zhang, et al. Biomimetic self-assembled nanosoldiers of paotianxiong polysaccharides and α-lipoic acid: Highly specific targeted therapy for mesangial proliferative glomerulonephritis.[J]. Materials today. Bio, 2026 doi:10.1016/j.mtbio.2026.103313.
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