Materials Today Bio今日材料·生物
Materials Today Bio(英文缩写 MATER TODAY BIO),ISSN 2590-0064,eISSN 2590-0064,中文译名:今日材料·生物 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 10.761 | Q1 |
| 2022 | 8.200 | Q1 |
| 2023 | 8.700 | Q1 |
| 2024 | 10.200 | Q1 |
| 2025 | 11.000 | Q1 |
Materials Today Bio 最新收录文献
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1. CPT-TCPP polymeric nanoplatform for sonodynamic-chemotherapy synergistic tumor therapy through ferroptosis-apoptosis dual cell death reprogramming.
1. CPT-TCPP聚合物纳米平台用于声动力化疗，通过铁凋亡-凋亡双细胞死亡重编程协同肿瘤治疗PMID:日期:2026-09-22Traditional cancer therapies are constrained by tumor diversity, therapeutic resistance, and side effects, thereby necessitating the development of precise multimodal antitumor strategies. This work reports a relatively high-drug-loading polymeric nanoplatform, PSCT, for combined sonodynamic therapy and chemotherapy. Camptothecin (CPT) and tetracarboxyphenylporphyrin (TCPP) were covalently linked to a polymer and self-assembled into stable nanoparticles of about 140 nm. PSCT enabled efficient co-delivery of both agents and favored tumor accumulation. In the reductive tumor microenvironment, elevated glutathione triggered disulfide cleavage and drug release. Under ultrasound (US) irradiation, TCPP generated ROS, resulting in lipid peroxidation and mitochondrial impairment. RNA-Seq analysis and molecular dynamics simulations indicated that PSCT combined with US reprogrammed a dual cell death network involving apoptosis and ferroptosis, accompanied by increased Cleaved Caspase-3 and decreased GPX4 expression. In CT26 tumor-bearing mice, PSCT showed efficient tumor accumulation and achieved an 85.19% ± 5.25% tumor inhibition rate without obvious systemic toxicity. This nanoplatform synergizes sonodynamic therapy and chemotherapy, overcoming resistance from single-pathway treatments and providing a low-toxicity strategy for the precise management of deep-seated tumors.
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2. A label-free supramolecular nanoassembly triggers multi-organelle crosstalk-dependent metastasis inhibition via nuclear ROS-HDAC2 axis.
2. 一种无标记超分子纳米组装体通过核ROS-HDAC2轴触发多细胞器串扰依赖性转移抑制PMID:日期:2026-09-20Tumor metastasis, a leading cause of cancer-related mortality, presents a significant challenge due to its complex, multi-step nature and tumor cells' adaptability. Current targeted therapies often face limitations as tumor cells activate compensatory signaling pathways, leading to drug resistance. Here, we introduce a novel molecular drug pair of sorafenib (Sora) and curcumin (Cur) self-assembled into Sora-Cur@diploid nanoparticles (diNPs), which were transformed into label-free diNP@pharmaceutical dots (diNP@PDs) with enhanced fluorescence through a specialized formulation process, eliminating the need for chemical modification. diNP@PDs exhibit photoluminescence capability, simultaneously promoting cross-talk among lysosomes, mitochondria, and nuclei. This lysosomes-mitochondria-nuclei interaction induces perinuclear clustering of organelles, triggering nuclear reactive oxygen species (nuROS) generation. The nuROS epigenetically suppresses HDAC2 activity, inhibiting epithelial-mesenchymal transition (EMT) and tumor metastasis. By integrating multi-organelle targeting with molecular therapy, diNP@PDs offer an innovative strategy for both imaging and inhibiting tumor metastasis, highlighting the potential of interorganelle approaches in oncology.
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3. Intensity-dependent microcurrent stimulation enhances BMSC-derived cartilage microtissue formation under defined culture conditions.
PMID:日期:2026-09-19Engineering phenotypically favorable cartilage-like tissue from bone marrow mesenchymal stem cells (BMSCs) remains challenging because chondrogenic differentiation can be accompanied by insufficient cartilage-associated extracellular matrix accumulation and unfavorable hypertrophic and catabolic responses. Here, we established a microcurrent-assisted culture system for scaffold-free BMSC-derived cartilage microtissues (CMTs) and investigated the intensity-dependent effects of continuous unidirectional direct-current stimulation at 0, 50, 100, 150, 250, or 500 μA under a defined electrical and culture configuration. Among the tested conditions, 150 μA (nominal electrode current density, 3 μA/mm) showed the most consistently favorable overall response, with enhanced cartilage-associated gene and protein expression, greater type II collagen- and glycosaminoglycan-rich matrix accumulation, improved CMT morphology, and higher apparent mechanical properties. In contrast, 250 and 500 μA were associated with reduced cartilage-associated matrix formation and increased fibrotic, hypertrophic, catabolic, inflammatory, and apoptosis-related markers. The 150 μA condition was also associated with a distinct intracellular Ca response pattern and increased NFATc1 nuclear localization; verapamil, BAPTA-AM, and cyclosporin A attenuated NFATc1 nuclear localization, supporting involvement of Ca/calcineurin/NFAT-related signaling without establishing a unique causal mechanism. After 2 weeks of xenogeneic subcutaneous implantation in nude mice, CMTs preconditioned at 150 μA exhibited greater cartilage-like matrix accumulation and higher apparent compressive properties than those preconditioned at 0 or 500 μA. These findings identify 150 μA as the best-performing tested condition under the present electrical configuration and provide short-term ectopic proof-of-concept evidence, while longer-term orthotopic studies are required to evaluate phenotypic stability, tissue integration, and functional outcomes in cartilage-defect models.
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4. A bio-based superhydrophobic pit and fissure sealant for enhanced stability and anticaries application.
PMID:日期:2026-09-18Dental caries is one of the most prevalent chronic diseases worldwide, with most lesions occurring in occlusal pits and fissures. To prevent occlusal caries, pit and fissure sealants are considered one of the most effective measures. However, their anticaries effect are often compromised by secondary caries resulting from biofilm accumulation. Furthermore, traditional sealants based on bisphenol A glycidyl methacrylate (Bis-GMA) may release bisphenol A (BPA), raising concerns about potential endocrine disruption. In this study, we developed a bio-based superhydrophobic pit and fissure sealant by utilizing isosorbide dimethacrylate (IM) as a bio-based resin matrix, fluorinated methacrylate (FMA) as a low-surface-energy component, and a combination of micro- and nano-sized SiO to construct a micro-nano hierarchical surface architecture, after light curing treatment. The bio-based micro-nano structured superhydrophobic pit and fissure sealant (m-n SUP) retained superhydrophobicity after immersion in artificial saliva for 5 days, thermocycling for 5000 cycles, pH cycling for 5000 cycles, tape peeling for 100 cycles, and sandpaper abrasion for 40 cycles. m-n SUP also exhibited favorable mechanical properties and enamel bonding comparable to those of the commercial sealant, together with favorable marginal sealing performance. Moreover, m-n SUP exhibited good cytocompatibility, and markedly reduced salivary mucin adsorption and provided sustained inhibition of the initial adhesion and biofilm formation for five representative oral cariogenic bacteria over 72 h. In a rat model, m-n SUP effectively reduced the incidence and severity of occlusal carie. Overall, this bio-based superhydrophobic pit and fissure sealant can provide a promising bio-based material strategy for pit and fissure caries prevention.
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5. Hypoxia-programmed apoptotic-mimetic M2 macrophage-derived small extracellular vesicles for hydrogel-mediated immunoregenerative bone repair.
5. 缺氧编程的凋亡模拟M2巨噬细胞来源小细胞外囊泡用于水凝胶介导的免疫再生骨修复PMID:日期:2026-09-18Effective regeneration of critical-sized bone defects requires the coordinated reconstruction of immune homeostasis, vascular networks, and osteogenic matrix formation. However, conventional bone-regenerative materials frequently provide structural support or single-pathway osteoinduction, while failing to actively orchestrate the multicellular repair microenvironment. Here, we develop a hydrogel-assisted immunoregenerative strategy based on hypoxia-programmed apoptotic-mimetic small extracellular vesicles derived from M2-like macrophages. Interleukin-4-polarized macrophages were subjected to hypoxic preconditioning to generate M2-HP-Apo-sEVs with increased phosphatidylserine exposure, enhanced cellular internalization, and amplified immunomodulatory potency. Compared with normoxic M2-sEVs, M2-HP-Apo-sEVs more effectively reprogrammed inflammatory macrophages toward a pro-resolving phenotype, suppressed inflammatory cytokine production, and enhanced reparative cytokine secretion. The vesicles further promoted osteogenic differentiation of bone marrow mesenchymal stem cells and stimulated endothelial migration and capillary-like network formation, demonstrating coordinated osteo-immuno-angiogenic activity. To enable sustained local delivery, M2-HP-Apo-sEVs were incorporated into photocrosslinkable GelMA hydrogels and implanted into critical-sized calvarial defects. The GelMA-M2-HP-Apo-sEV system substantially enhanced bone regeneration, vascularization, and osteogenic matrix deposition while attenuating local inflammation. This work establishes a cell-free vesicle-hydrogel platform that integrates donor-cell hypoxic programming, apoptotic-mimetic membrane signaling, and local biomaterial delivery for immunoregenerative bone repair.
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6. Bioactive polythioctic acid-engineered ropivacaine alleviates bone cancer pain through prolonged analgesia and multi-functional neuroprotection.
PMID:日期:2026-09-18Bone cancer pain (BCP), driven by tumor-induced bone destruction and central sensitization, represents a major clinical challenge. Although ropivacaine (Rop) is a cornerstone for BCP management, it fails to provide prolonged analgesia and neuroprotective benefits. Through RNA transcriptomics and phenotypic analysis in a murine model of metastatic BCP, we show that while Rop rapidly alleviates mechanical and thermal hyperalgesia, it paradoxically exacerbates spinal oxidative stress and neuroinflammation. To address this paradox, we engineered a multifunctional, redox-responsive polymer platform designed to prolong analgesia and mitigate Rop-associated neuronal injury concurrently. Leveraging polythioctic acid (PTA) with a responsive disulfide framework, the encapsulated Rop achieves a sustained release profile to facilitate prolonged analgesia under reductive tumor microenvironment. Meanwhile, the liberated thioctic acid (TA) acts as an antioxidant to ameliorate both neurotoxicity and neuroinflammation. Consequently, the PTA@Rop nanoparticle achieves a 1.6-fold extension of the analgesia window compared to free Rop , leading to preservation of bone microarchitecture and suppression of pro-inflammatory cytokine cascades. Mechanistically, transcriptomic profiling further reveals that PTA@Rop platform reshapes the spinal gene expression landscape and reduced nerve growth factor (NGF) homeostasis to suppress central sensitization. Our nanobiotechnology engineering decouples prolonged analgesia of Rop from unwanted neurotoxicity, providing proof-of-concept evidence for a mechanism-driven nanoplatform for BCP management.
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7. An integrated design strategy for structurally stable full-thickness human skin models with regulatory-qualified barrier assessment.
7. 具有监管合格屏障评估的结构稳定的全厚度人体皮肤模型的集成设计策略PMID:日期:2026-09-18Three-dimensional full-thickness (FT) human skin models provide advantages over reconstructed human epidermis (RhE) by incorporating dermal-epidermal interactions but face persistent challenges with scaffold detachment, contraction, and OECD-compatible barrier validation. In this study, we establish design strategy for full-thickness (FT) human skin by defining and implementing coordinated dermal and epidermal design principles that stabilize construct geometry and support regulatory-relevant barrier function. Quantitative analysis reveals that fibroblast-mediated detachment and contraction in dermal equivalents are governed by a critical fibroblast-per-collagen threshold, defining conditions that maintain structural integrity. In epidermal equivalents, keratinocytes alone can generate sufficient mechanical stress to detach and deform COL1 scaffolds, and poly(dopamine) (PDA) coating reinforces tissue-insert anchorage to suppress detachment and geometric deformation without altering keratinocyte activation. Incorporating a Matrigel/COL1 dermal matrix that provides a basement-membrane-derived matrix environment improved epidermal stratification and spatial separation of proliferative (Ki67-positive) and terminally differentiated (loricrin-positive) keratinocytes, while bulk RNA-seq and qPCR analyses show Matrigel-dependent upregulation of keratin, junctional, and barrier-associated genes. These structural and transcriptional changes translate into enhanced barrier function, as quantified by a direct gravimetric transepithelial water-loss (TEWL) and transepithelial electrical resistance (TEER) measurements. Under Triton X-100 exposure, the optimized FT-skin achieves an ET of 4.5 h, satisfying OECD Test Guideline 431 performance criteria (>2.0 h) and closely matching the ET of 5.0 h obtained with an RhE model, while OECD Test Guideline 439-compatible irritation testing correctly classifies non-irritant and irritant chemicals. This structurally stable, regulatory-aligned FT-skin integrates dermal and epidermal contributions to barrier function and embodies an integrated design strategy that provides practical, experimentally grounded design principles for assessment of skin corrosion, irritation, and future multi-component skin equivalents.
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8. Biomimetic nanoparticles camouflaged with M2 macrophage membrane for osteoporosis therapy: A triple-action strategy that upregulates anti-inflammation and osteogenic responses while suppressing MMP-9.
8. 仿生纳米颗粒伪装M2巨噬细胞膜用于骨质疏松症治疗：一种上调抗炎和成骨反应同时抑制MMP-9的三重作用策略PMID:日期:2026-09-18Osteoporosis is a systemic skeletal disorder characterized by bone loss and microstructural deterioration, and its pathogenesis is closely associated with dysregulation of the bone marrow immune microenvironment. In this study, bioinformatic analysis first revealed significant oxidative stress and mitochondrial metabolic dysfunction in macrophages within the osteoporotic microenvironment. Based on this, we constructed a biomimetic nanoplatform (ZCM2) composed of ZIF-8@CaCO core-shell nanoparticles camouflaged with M2 macrophage membranes, designed to achieve comprehensive osteoporosis therapy through a triple synergistic mechanism: the ZIF-8 core scavenges reactive oxygen species to exert antioxidant and anti-inflammatory effects, inhibits MMP-9 secretion to reduce pathological bone resorption, and the CaCO shell releases calcium ions to promote osteogenic differentiation. ZCM2 exhibited favorable biosafety, high cellular uptake efficiency, and excellent bone-targeting capability. Mechanistic studies demonstrated that ZCM2 upregulates the expression of Nrf2 and HO-1, downregulates the expression of NF-κB p65, and significantly reduces the secretion of matrix metalloproteinase-9 (MMP-9) by macrophages, thereby attenuating bone resorption. Meanwhile, calcium ions released from the CaCO shell activate the RUNX2/OSX/OPN signaling axis, promoting osteogenic differentiation of bone marrow mesenchymal stem cells. In an ovariectomized mouse model of osteoporosis, ZCM2 markedly improved bone microarchitecture, promoted new bone formation, and effectively inhibited bone resorption activity. Collectively, this biomimetic nanoplatform integrates anti-inflammatory, anti-resorptive, and pro-osteogenic functions, offering a multifaceted synergistic therapeutic strategy for osteoporosis.
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9. Engineered naringenin-loaded nanoscale coordination polymers for targeted treatment of acute kidney injury.
PMID:日期:2026-09-18Acute kidney injury (AKI) is a severe clinical condition lacking targeted and effective pharmacotherapies. Dysregulated inflammation, largely driven by the nuclear factor-κB (NF-κB) signaling pathway, is a primary mediator of tubular damage in AKI. While bioinformatic and preliminary analyses identified the natural flavonoid naringenin (Nag) as a potent NF-κB inhibitor, its therapeutic utility is severely restricted by poor aqueous solubility, rapid systemic metabolism, and insufficient renal accumulation. To address these pharmacokinetic limitations, we synthesized ultra-small (<10 nm) iron-naringenin nanoscale coordination polymers (Fe-Nag NPs). This sub-10 nm design exploits glomerular filtration for passive targeting, specifically leveraging the enhanced vascular permeability of injured kidneys. In both ischemia-reperfusion (IR) and cisplatin-induced murine AKI models, Fe-Nag NPs achieved significantly higher renal drug concentrations compared to free naringenin administration. This targeted delivery substantially improved therapeutic outcomes, as evidenced by restored renal function, attenuated acute histopathological lesions, and the profound suppression of pro-inflammatory cascades. Furthermore, Fe-Nag NPs provided sustained renoprotection, effectively mitigating the functional transition from severe AKI to chronic kidney disease (CKD). By seamlessly integrating transcriptomic insights with functional nanomaterial design, this metal-organic platform not only validates targeted NF-κB inhibition for AKI treatment but also offers a robust strategy for the precise delivery of poorly soluble bioactive natural products.
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10. {"_":"High-quantity capture of heterogeneous circulating tumor cells based on a multinanobody-functionalized carboxymethyl cellulose cryogel.","i":["in vivo"]}
10. {"_":"基于多纳米抗体功能化羧甲基纤维素冷冻凝胶的异质性循环肿瘤细胞的高通量捕获。","i":["体内"]}PMID:日期:2026-09-17Circulating tumor cells (CTCs) carry multidimensional information from primary tumors, yet current separation strategies lead to insufficient quantity of cells available for robust downstream analyses. To address this issue, we propose an capture strategy for high-quantity CTC enrichment based on a multinanobody-functionalized carboxymethyl cellulose cryogel (MNB-PAAC). By addressing the trade-off between pore size and mechanical property, the MNB-PAAC sets up a sieving barrier in the bloodstream. It allows free passage of blood cells through its interconnected macropores, while enhancing CTC-nanobody interactions, contributing to a high CTC capture efficiency of 72.3 ± 4.5% in the bloodstream. Consequently, up to 2.7 × 10 CTCs could be harvested from 4000 mL blood at 1 CTC/mL using 0.1 cm of the MNB-PAAC. experiments on cancer rat models demonstrated that the MNB-PAAC could capture diverse CTC subtypes across multiple cancers, and the captured CTCs exhibited consistent information with the primary tumor tissues. With its robust capability for high-quantity CTC enrichment, the proposed strategy will not only improve the reliability of CTC-based cancer analysis, but may also facilitate the establishment of patient-derived tumor organoid, showing great potential to accelerate the development of personalized cancer medicine.