用于胶质瘤靶向双模成像和自氧光疗的氟化电荷可逆酞菁纳米乳剂
Fluorinated charge-reversible phthalocyanine nanoemulsions for glioma-targeted dual-modal imaging and self-oxygenated phototherapy.
摘要(中文译文)
胶质瘤是高度侵袭性的脑肿瘤，预后较差，受限于靶向性不足、肿瘤缺氧及限制性血脑屏障（BBB）。在此，我们提出一种氟化酞菁锰基纳米乳剂，用于胶质瘤的双模态成像和有效光疗。通过侧链修饰和锰螯合工程化的两亲性酞菁表现出“开启型”近红外荧光（NIRF）、敏感的氟-19磁共振成像（F MRI）以及高光疗效力。与氟化油自组装并包覆叶酸修饰的电荷可逆聚合物，制备出成像灵敏度和光疗效力显著增强的纳米乳剂。体外和体内研究证明其具有优异的肿瘤靶向性、深部穿透、高效细胞摄取、双细胞器定位，并可诱导凋亡和焦亡。在原位胶质瘤模型中，该纳米乳剂可穿越血脑屏障、在肿瘤中蓄积、抑制肿瘤生长并延长生存期，且无明显全身毒性。该策略凸显了将光敏剂工程化与智能纳米乳剂设计相结合，用于靶向、高效和成像引导癌症治疗的前景。
Abstract
Gliomas are highly aggressive brain tumors with poor prognosis, limited by inadequate targeting, tumor hypoxia, and the restrictive blood-brain barrier (BBB). Here, we present a fluorinated phthalocyanine manganese-based nanoemulsion for dual-modal imaging and effective phototherapy of gliomas. The amphiphilic phthalocyanine, engineered through side-chain modification and Mn chelation, exhibits "turn-on" near-infrared fluorescence (NIRF), sensitive fluorine-19 magnetic resonance imaging (F MRI), and high phototherapy efficacy. Self-assembly with fluorinated oil and coating with a folic acid-modified charge-reversible polymer produces a nanoemulsion with markedly enhanced imaging sensitivity and phototherapeutic efficacy. and studies demonstrate superior tumor targeting, deep penetration, efficient cellular uptake, dual-organelle localization, and induction of both apoptosis and pyroptosis. In orthotopic glioma models, the nanoemulsion crosses the BBB, accumulates in tumors, suppresses tumor growth, and prolongs survival without obvious systemic toxicity. This strategy underscores the promise of integrating photosensitizer engineering with smart nanoemulsion design for targeted, efficient, and imaging-guided cancer therapy.
如何引用
AMA
Tingjuan Wu, Qiao Yu, Jing Zhang, Lijun Zhu, Chaohui Ye, Xin Zhou, et al. Fluorinated charge-reversible phthalocyanine nanoemulsions for glioma-targeted dual-modal imaging and self-oxygenated phototherapy.. Materials today. Bio. 2026; doi:10.1016/j.mtbio.2026.103269.
APA
Tingjuan Wu, Qiao Yu, Jing Zhang, Lijun Zhu, Chaohui Ye, Xin Zhou, et al (2026). Fluorinated charge-reversible phthalocyanine nanoemulsions for glioma-targeted dual-modal imaging and self-oxygenated phototherapy.. Materials today. Bio. https://doi.org/10.1016/j.mtbio.2026.103269
GB/T 7714
Tingjuan Wu, Qiao Yu, Jing Zhang, Lijun Zhu, Chaohui Ye, Xin Zhou, et al. Fluorinated charge-reversible phthalocyanine nanoemulsions for glioma-targeted dual-modal imaging and self-oxygenated phototherapy.[J]. Materials today. Bio, 2026 doi:10.1016/j.mtbio.2026.103269.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出