用于组织修复和再生的细胞衍生囊泡改性生物材料
Cell-derived vesicle-modified biomaterials for tissue repair and regeneration.
摘要(中文译文)
近年来，细胞来源囊泡修饰的生物材料（CDVMBs）被认为是一种有前景的策略，可克服传统生物材料在组织修复与再生中的局限性。通过将生物材料载体与细胞来源囊泡相结合，CDVMBs整合了载体的功能优势，包括支持细胞黏附、定植、增殖和功能化，同时融入了细胞来源囊泡的生物活性特性。在本综述中，“细胞来源囊泡”一词指用于载体修饰的两种不同的仿生组分：细胞膜囊泡，主要保留膜相关受体和界面生物学功能；以及外泌体，即富含蛋白质和核酸等生物活性货物的纳米级细胞外囊泡。因此，CDVMBs既可模拟源细胞的表面生物学特性，也可模拟由外泌体货物介导的信号传导功能，从而促进与受损组织的相互作用并刺激组织再生。基于生物材料仿生策略和囊泡来源，CDVMBs被分为细胞膜伪装生物材料（CMCBs）和外泌体修饰生物材料（EMBs）。本综述总结了其工程化策略、生物学机制以及在组织修复中的多样化应用，并进一步讨论了当前面临的挑战和临床转化的未来前景。综上所述，生物材料载体与细胞来源囊泡的整合建立了一个多功能的仿生框架，用于工程化再生微环境并推进组织修复与再生。
Abstract
In recent years, cell-derived vesicle-modified biomaterials (CDVMBs) have been considered a promising strategy to overcome the limitations of traditional biomaterials in tissue repair and regeneration. By combining biomaterial carriers with cell-derived vesicles, CDVMBs integrate the functional advantages of the carriers, including support for cell adhesion, colonization, proliferation, and functionalization, while also incorporating the bioactive properties of cell-derived vesicles. In this review, the term "cell-derived vesicles" refers to two distinct bioinspired components used for carrier modification: cell membrane vesicles, which mainly retain membrane-associated receptors and interfacial biological functions, and exosomes, which are nanosized extracellular vesicles enriched in bioactive cargos such as proteins and nucleic acids. Accordingly, CDVMBs can mimic either the surface biological properties of source cells or the signaling functions mediated by exosomal cargos, thereby promoting interactions with damaged tissues and stimulating tissue regeneration. Based on the biomaterial biomimetic strategy and vesicle source, CDVMBs are classified into cell membrane-camouflaged biomaterials (CMCBs) and exosome-modified biomaterials (EMBs). This review summarizes their engineering strategies, biological mechanisms, and versatile applications for tissue repair, and further discusses the current challenges and future perspectives for clinical translation. Taken together, the integration of biomaterial carriers with cell-derived vesicles establishes a versatile bioinspired framework for engineering regenerative microenvironments and advancing tissue repair and regeneration.
如何引用
AMA
Wanli Song, Junmiao Xue, Pengfei Jia, Yongzhi Xu, Hao Jiang, Zhiyu Yuan, et al. Cell-derived vesicle-modified biomaterials for tissue repair and regeneration.. Materials today. Bio. 2026; doi:10.1016/j.mtbio.2026.103263.
APA
Wanli Song, Junmiao Xue, Pengfei Jia, Yongzhi Xu, Hao Jiang, Zhiyu Yuan, et al (2026). Cell-derived vesicle-modified biomaterials for tissue repair and regeneration.. Materials today. Bio. https://doi.org/10.1016/j.mtbio.2026.103263
GB/T 7714
Wanli Song, Junmiao Xue, Pengfei Jia, Yongzhi Xu, Hao Jiang, Zhiyu Yuan, et al. Cell-derived vesicle-modified biomaterials for tissue repair and regeneration.[J]. Materials today. Bio, 2026 doi:10.1016/j.mtbio.2026.103263.
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