ENVIRONMENTAL POLLUTION环境污染
ENVIRONMENTAL POLLUTION(英文缩写 ENVIRON POLLUT),ISSN 0269-7491,eISSN 1873-6424,中文译名:环境污染 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 9.988 | Q1 |
| 2022 | 8.900 | Q1 |
| 2023 | 7.600 | Q1 |
| 2024 | 7.300 | Q1 |
| 2025 | 7.200 | Q1 |
ENVIRONMENTAL POLLUTION 最新收录文献
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1. Mechanistic insight into Metabolic Activation Mechanism of Aniline Disinfection Byproducts catalyzed by P450 Enzymes from Distinct Species: N-hydroxylation Mechanism.
PMID:日期:2026-10-03Disinfection by-products (DBPs) are emerging environmental pollutants generated from reactions between disinfectants and precursor compounds in the water treatment, which pose a serious toxicity effect to the ecological environment and human health. Metabolism, especially by P450 enzymes, is responsible for both the toxification and detoxification of xenobiotics in humans and other organisms. Multidisciplinary theoretical approaches utilizing density functional theory (DFT), quantitative structure-activity relationship (QSAR), and quantum mechanics/molecular mechanics (QM/MM) are used to investigate the metabolic mechanism of aniline DBPs (AN-DBPs) catalyzed by P450 enzymes. The high-throughput DFT calculations confirm that the N-hydroxylation represents a feasible metabolic pathway for AN-DBPs, with the OH rebound reaction serving as the rate-determining step. A machine learning driven QSAR model is developed to predict the energy barriers of the rate-determining step involved in N-hydroxylation for AN-DBPs through employing four molecular descriptors derived from Mordred platform. The QSAR model shows relatively high predictive accuracy, with R values of approximately 0.8. The QM/MM calculations characterize the reaction energy barriers and structural details for the H-abstraction and OH rebound pathways of 2,6-dichloroaniline catalyzed by P450 enzymes from four different species, revealing that zebrafish P450 enzyme is the most readily activated metabolically upon exposure to AN-DBPs. Furthermore, the potential toxicity effects of AN-DBPs and their metabolites are predicted by in silico methods, and the results demonstrate that the metabolites generated from P450-mediated biotransformation process exhibit higher predicted toxicity than the parent AN-DBPs. These unveiled metabolic profiles offer valuable insights for the risk evaluation of AN-DBPs, which can guide future research and regulatory actions.
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2. Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages.
2. 多组学分析揭示6PPDQ暴露巨噬细胞中氧化应激相关的甘油磷脂代谢改变和炎症反应PMID:日期:2026-10-03N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), a transformation product of the tire antioxidant 6PPD, is an emerging environmental contaminant with increasing toxicological concern. While macrophages are critical in recognizing and managing chemical stress, how 6PPDQ exposure perturbs their innate immune functions and intracellular metabolic homeostasis remains largely unexplored. Here, RAW 264.7 macrophages were exposed to 6PPDQ and examined using biochemical assays, integrated transcriptomic and metabolomic analyses, and N-acetylcysteine (NAC)-based antioxidant intervention. Exposure to 6PPDQ caused dose-dependent cellular injury, characterized by increased membrane damage, excessive reactive oxygen species (ROS) accumulation, glutathione depletion, inflammatory mediator upregulation, mitochondrial dysfunction, and enhanced apoptosis. Multi-omics analysis further revealed significant alterations in glycerophospholipid-related metabolic profiles, accompanied by enrichment of TNF and NF-κB inflammatory signaling. Several phospholipid species levels were decreased, whereas the level of lysophosphatidic acid (LPA) and the expression of its related genes Gpat3 and Lpar2 were markedly elevated. Pretreatment with NAC not only suppressed ROS accumulation, but also attenuated both lipid metabolic and inflammatory alterations induced by 6PPDQ. Collectively, these findings suggest that oxidative stress is closely associated with alterations in glycerophospholipid-related metabolic profiles and inflammatory responses during 6PPDQ-induced macrophage injury.
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3. Complement C3 in the silica nanoparticles protein corona promotes macrophage M1 polarization and subacute pulmonary fibrotic remodeling.
3. 二氧化硅纳米颗粒蛋白冠中的补体C3促进巨噬细胞M1极化和亚急性肺纤维化重塑PMID:日期:2026-10-03Silica nanoparticles (SiNPs), widely used in diverse industrial and biomedical applications, are ubiquitous environmental pollutants of emerging concern, posing significant risks to human respiratory health via inhalation exposure. Substantial evidence demonstrates that inhaled SiNPs induce pulmonary fibrosis. Nevertheless, the underlying pathogenic mechanisms remain elusive. While nanomaterials adsorb proteins to form a protein corona that alters their biological activity and contributes to nanoparticle-induced tissue damage, whether this process contributes to SiNPs-induced pulmonary fibrosis remains incompletely characterized. We demonstrated that SiNPs exposure promoted subacute pulmonary fibrotic remodeling and induced macrophage M1 polarization in mice. In vitro, SiNPs formed a protein corona with mouse bronchoalveolar lavage fluid (BALF). The SiNPs protein corona promoted RAW264.7 cells toward M1 phenotype. Integrated proteomic profiling of isolated coronas by LC-MS and human pulmonary fibrosis transcriptomes identified complement C3 as a key corona protein that promoted macrophage M1 polarization and contributed to subacute pulmonary fibrosis progression among the isolated coronas. Mechanistically, the SiNPs-C3 corona enhanced CD86 and MHC-II expression in RAW264.7 cells via the NLRP3/TNF-α/IL-1β axis and directly activated fibroblasts. Pharmacologic blockade of complement C3 with the peptidic inhibitor Cp40 attenuated complement C3 activation, macrophage M1 polarization, and pulmonary fibrosis. Collectively, these findings revealed that complement C3 as a key corona component contributed to SiNPs-induced subacute pulmonary fibrotic remodeling. Complement C3 represented a potential therapeutic target for SiNPs-induced subacute pulmonary fibrosis, providing a rationale for future immunomodulatory therapies.
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4. Dietary exposure to inorganic mercury and methylmercury in Dreissena polymorpha: tissue- and form-specific bioaccumulation, multi-omics and oxidative stress responses.
4. 斑马贻贝中无机汞和甲基汞的膳食暴露：组织特异性和形态特异性的生物累积、多组学及氧化应激响应PMID:日期:2026-10-03Methylmercury (MeHg), despite its low aqueous concentration, poses significant ecotoxicological risks in aquatic food webs. However, its dietary impacts on freshwater biota at environmentally relevant concentrations remain poorly understood. This study investigated bioaccumulation and molecular toxicity pathways in Dreissena polymorpha using transcriptomics, proteomics, metabolomics, and oxidative stress biomarkers following dietary exposure to inorganic Hg (IHg) and MeHg. Data revealed tissue-specific bioaccumulation patterns: the digestive gland, primary site of metal detoxification, accumulated higher total Hg (THg) concentrations, whereas gills showed higher %MeHg, suggesting an additional uptake pathway during filtration. Enzymatic activities and lipid peroxidation levels indicated the absence of oxidative stress, congruent with low exposure concentrations and bioaccumulation. At the molecular level, IHg primarily altered transcriptomic profiles, indicating a regulatory response, while MeHg induced broader proteomic and metabolomic disruptions. Enrichment analyses using The Kyoto Encyclopedia of Genes and Genomes (KEGG) revealed distinct but overlapping pathways. IHg predominantly affected pathways related to amino acid metabolism, environmental information processing, and disease, while MeHg mainly affected energy, lipid, and carbohydrate metabolism, as well as immune and digestive system. These differences suggest contrasting toxicity pathways: IHg primarily disrupted cellular regulation and signaling, whereas MeHg targeted core metabolic and immune processes, reflecting its greater biological reactivity and bioaccumulation potential. Moreover, gills exhibited higher transcriptomic and proteomic responses, whereas the digestive gland showed higher metabolic adjustments, potentially reflecting differences in Hg exposure and tissue-specific Hg accumulation. By coupling functional biomarkers with multi-omics approaches, this study provides new insights into Hg toxicity in freshwater ecosystems and highlights the importance of tissue-specific assessments.
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5. {"_":"Estimating marine PM concentrations and exploring the drivers over the eastern China seas using multi-source data and machine learning.","sub":["2.5"]}
5. {“_”：“利用多源数据和机器学习估算海洋PM浓度并探索中国东部海域的驱动因素。”，“sub”：[“PMID:日期:2026-10-03Fine particulate matter (PM) plays an important role in marine ecosystems and regional climate processes. However, accurate monitoring of PM over marine environments remains challenging due to sparse ground observations and the complex interactions among meteorological conditions, atmospheric chemistry, and pollutant transport. To address this issue, a multi-source data framework for estimating PM concentrations over the eastern China seas was developed by integrating aerosol optical depth (AOD), meteorological variables, and atmospheric chemical parameters (NO, CO, O, and SO). Three machine learning algorithms, including Back Propagation Neural Network (BPNN), Random Forest (RF), and eXtreme Gradient Boosting (XGBoost), were evaluated using sample-based, spatial-based, and temporal-based validation strategies. Results show that XGBoost demonstrated competitive performance among the three models across the different validation strategies, suggesting that the proposed framework is applicable to marine PM estimation. Based on the XGBoost-derived PM estimates, the spatio-temporal variations and dominant influencing factors of marine PM from 2019 to 2024 were further examined. The estimated PM concentrations showed a clear decreasing gradient from west to east and from north to south, with high-value areas mainly located in Bohai Bay and the Shandong coastal regions, indicating a strong influence from terrestrial emissions and coastal pollutant transport. Temporally, PM showed a fluctuating downward trend and a stable seasonal cycle, with winter maxima and summer minima. The marked decline in 2020 further reflected the response of marine PM to changes in inland anthropogenic emissions. SHapley Additive exPlanations (SHAP) analysis showed that AOD dominated PM variations in spring, summer, and autumn, whereas reduced boundary layer height, enhanced northwesterly transport, and increased pollution-related gases such as NO and CO jointly promoted wintertime PM accumulation. These findings demonstrate the value of integrating atmospheric chemical parameters into marine PM estimation and provide insights into air pollution mechanisms over the eastern China seas.
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6. Watershed urbanization and sanitation as predictors of microplastic contamination in stream sediments.
PMID:日期:2026-10-03Urbanization represents a major land-use change with substantial impacts on stream ecosystems. Urban streams are exposed to a wide range of contaminants, including microplastics (MPs), which enter these systems primarily through wastewater and stormwater runoff. However, the effects of urbanization and sanitation coverage on MPs accumulation in subtropical streams remain poorly understood. This study examined the influence of urbanization intensity and sanitation coverage on MP accumulation in sediments from 16 urban streams across five cities in Uruguay, representing a gradient of urbanization and access to sanitation. Higher MP abundances were observed in sediments from streams under greater urban pressure, whereas MPs levels decreased with increasing proportions of households with access to sanitation. Polymer composition was dominated by polyethylene and polypropylene, which are commonly associated with domestic and urban waste. PERI provided a comparative ranking among the sampled streams but should not be interpreted as a measure of actual ecological risk. These results emphasize the need to consider both the degree of urbanization and inequalities in access to services such as sanitation. In addition, the findings highlight the importance of including emerging contaminants such as MPs in comprehensive environmental assessments. This evidence can support the development of public policies aimed at mitigating the impacts of urbanization on aquatic ecosystems and promoting equitable and sustainable territorial management.
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7. Developmental toxicities of albendazole and its metabolites in zebrafish (Danio rerio) embryos.
7. 阿苯达唑及其代谢物对斑马鱼（Danio rerio）胚胎的发育毒性PMID:日期:2026-10-02Albendazole (ABZ) is a benzimidazole anthelmintic medicine widely used in livestock and, especially, aquaculture industries. Given its widespread use, ABZ commonly enters waterways, negatively impacting aquatic organisms. Classified as Pregnancy Category C because of its teratogenic properties, ABZ poses a high risk of developmental toxicity. In this study, zebrafish (Danio rerio) embryos were used to assess the developmental toxicity of ABZ and its two metabolites, ABZ-sulfoxide and ABZ-sulfone. Among these, only ABZ exhibited strong lethality, demonstrating an LC value of 83.3 μg/L, and induced extensive phenotypic changes, including pericardial edema and reduced midbrain and eye areas. Using Tg(cmlc2:EGFP) embryos to assess cardiac morphology, 75 μg/L of ABZ was confirmed to induce a vertical alignment of the atrium and ventricle, instead of the normal S-shaped configuration, and significant reductions in heart rate and ejection fraction were observed. Using ABZ-treated Tg(HuC:EGFP) embryos, neurodevelopmental toxicity was confirmed, with 75 μg/L of ABZ eliminating both intraocular and cranial neuronal signaling. Moreover, early neural function, assessed using tail coiling frequency at 24 h post-fertilization, was significantly reduced in ABZ-treated embryos. Impaired optic neurogenesis was also confirmed, with significant decreases in pax2a and pax6a gene expression. Acridine orange staining identified apoptotic changes, mainly in the head, and inflammatory responses increased in ABZ-treated Tg(mpx:EGFP) embryos, accompanied by increases in mpx (neutrophil marker, 3-fold) and il1β (cytokine, 30-fold) expression. This study showed that ABZ induced severe developmental toxicity at low concentrations, demonstrating that its presence in the environment should be carefully monitored.
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8. From diagnostic device to environmental contaminant: Leachate release from nano-enabled pregnancy tests and associated toxicity during early development stages of zebrafish (Danio rerio).
8. 从诊断设备到环境污染物：斑马鱼（Danio rerio）早期发育阶段纳米妊娠试验的渗滤液释放和相关毒性PMID:日期:2026-10-02Single-use pregnancy test kits, which are widely used, are lateral flow assays (LFAs) that rely on gold nanomaterials (nAu) to produce a visual, rapid readout through colorimetric test lines. However, their environmental impact after disposal remains unclear. This study focused on assessing the release, physiochemical characteristics, and biological effects of nAu-containing leachates from two different pregnancy test kits with differing strip designs (dip-type, laminated vs. midstream, non-laminated, in a removable cassette). The leaching of chemicals from the strips into water was induced by placing used pregnancy test strips in water in different simulated landfill conditions (elevated temperature, low oxygen availability, and extended incubation times). The resulting leachates were characterised using UV-Vis spectroscopy, dynamic light scattering and transmission electron microscopy (TEM). Characterisation of the strips was done using attenuated total reflectance Fourier transform infrared spectroscopy and scanning electron microscopy with energy dispersive X-ray spectroscopy. The selected LFAs released detectable amounts nAu, and visualization using TEM confirmed mean sizes of 8.2 ± 2.9 nm in P and 4.5 ± 2.0 nm for P. FTIR of the strips confirmed that they are mainly composed of polymers such as polyethylene, adhesives, cellulose, and nitrocellulose. Following confirmation that the leachates contained nAu, it was important to assess the biological effects of these leachates. Zebrafish (Danio rerio) were used to conduct fish embryo acute toxicity tests in accordance with the OECD Test Guideline 236. Toxicity effects, including coagulation, oedema formation, deformities, and abnormal swimming behaviours, were significantly induced after exposure to low dose concentrations of the leachates; however, the extent of these effects varied between the LFA types. Neurobehavioral assessment using the optokinetic response assay indicated dose-dependent disrupted visual motor function in exposed larvae (96 hours post-fertilisation). These findings identify pregnancy tests as an overlooked source of contamination in aquatic environments, releasing nAu-containing leachates that can induce toxic effects and highlight the need for safe and sustainable-by-design materials.
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9. Anthropogenic noise alters tropical soundscapes: insights from acoustic network analysis.
9. 人为噪声改变了热带音景：来自声学网络分析的见解PMID:日期:2026-10-02Anthropogenic noise is an increasingly pervasive driver of environmental change, with mining emerging as a major global source of acoustic disturbance, particularly in tropical ecosystems that harbour most of the world's biodiversity. Because animal acoustic communication underpins key behaviours such as mate attraction, territory defence and predator avoidance, understanding how noise impacts soundscapes is critical for conservation. However, robust metrics capable of capturing these impacts remain limited. Here, we propose co-occurrence patterns as a novel proxy to quantify the effects of noise pollution on soundscapes. We conceptualise soundscapes as dynamic networks formed by biophony, geophony and anthropophony. We monitored soundscapes in the Atlantic Forest (Minas Gerais, Brazil), comparing sites located near an opencast mine and 2.5 km away. Four passive acoustic recorders sampled continuously for seven days bimonthly over one year. We focused on mining truck passages as the dominant noise source and analysed animals' acoustic signals co-occurrence before, during and after these events to construct acoustic networks. Network Portrait Divergence was performed to assess structural differences between networks. Network metrics (nodes, edges and centrality) and divergences revealed clear shifts in soundscape structure. Complexity was highest during the wet season without noise, while lowest complexity occurred during noisy periods in the dry season. Although central species retained their relative positions, overall network dynamics changed during noise events. These results suggest that anthropogenic noise alters soundscape structure rather than simply displacing key species, compromising overall acoustic dynamics. Our findings highlight acoustic networks as a promising and scalable tool to detect and interpret noise impacts on biodiversity.
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10. Wastewater inputs and hydrological variability shape catchment-scale transport of polychlorinated dibenzo-p-dioxin and dibenzofuran-like immunoreactivity.
10. 废水输入和水文变化塑造了多氯二苯并对二恶英和二苯并呋喃样免疫反应性的集水区规模迁移PMID:日期:2026-10-02Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) are persistent hazardous pollutants whose riverine transport is shaped by wastewater discharges and hydrological variability. This study quantified PCDD/F-like immunoreactivity, expressed as PCDD/F ELISA equivalents (PCDD/F ELISA-EQ), in untreated and treated wastewater from 17 municipal wastewater treatment plants (WWTPs)-seven small, five medium-sized, and five large-and at eight sites along the Pilica River over two annual cycles. The assay-derived PCDD/F ELISA-EQ metric used in this study is a screening measure distinct from congener-specific PCDD/F concentrations and World Health Organization Toxic Equivalents (WHO-TEQ). Wastewater treatment reduced PCDD/F ELISA-EQ concentrations and loads by 85.9-92.8% and 79.8-90.8%, respectively, across the 17 WWTPs. WWTP size did not significantly affect concentration-reduction efficiency (one-way analysis of variance: F = 0.410, p = 0.665), whereas large WWTPs generated the highest residual loads because of their greater hydraulic throughput. Riverine PCDD/F ELISA-EQ did not follow a consistent downstream gradient but occurred as spatially and seasonally variable pulses. The highest daily loads were recorded in the middle river section during winter high-flow conditions, indicating strong hydrological amplification of contaminant transport. The Sulejów Reservoir appeared to modify this pattern, potentially reflecting dilution and retention processes within the reservoir. Multivariate analyses linked PCDD/F ELISA-EQ mainly with organic matter, suspended solids and redox conditions. These findings show that concentration-based monitoring alone is insufficient to characterize PCDD/F-related pressure. Integrating screening-level PCDD/F ELISA-EQ data with wastewater discharge, river flow and load estimates provides a more robust framework for identifying and prioritizing critical periods, high-load facilities, and vulnerable river sections.