TRENDS IN GENETICS遗传学趋势
TRENDS IN GENETICS(英文缩写 TRENDS GENET),ISSN 0168-9525,eISSN 1362-4555,中文译名:遗传学趋势 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 11.821 | Q1 |
| 2022 | 11.400 | Q1 |
| 2023 | 13.600 | Q1 |
| 2024 | 16.300 | Q1 |
| 2025 | 12.900 | Q1 |
TRENDS IN GENETICS 最新收录文献
-
1. How mutagenic are transposable elements?
1. 转座元件有多强的致突变性？PMID:日期:2026-09-29Even though transposable elements (TEs) are known to be ubiquitous, studies on mutation rates often overlook this dynamic component of the genome. Fortunately, both our understanding of the mechanisms and assays of movement within and between lineages have expanded. In this review, we aggregate direct estimates of TE mutation rates from the literature to quantify the mutagenicity of mobile DNA. Overall, based on a subset of comparable studies, the mean rate of gain is 1.6 × 10 elements per copy per generation, an order of magnitude faster than the mean rate of loss (1.9 × 10). We discuss challenges for comparing rates across studies and outline the major genotypic and phenotypic consequences of TE movement. In conclusion, TEs can no longer be sidelined as 'junk' given the genetic variation they generate. Instead, we argue the role of TEs as an endogenous mutagen means they demand a more central place in mutation research.
-
2. Richer together: genetics and spirituality in public conversation.
2. 共同丰富：公共对话中的遗传学与灵性PMID:日期:2026-09-29Using a conference on genetics and spirituality as a case study, this article examines strategies for engaging diverse audiences in conversations about Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and related genetic technologies. Six lessons are identified for fostering constructive dialog, mutual learning, and public engagement across scientific and spiritual communities.
-
3. DNA methylation: unifying framework for complex chronic conditions.
3. DNA甲基化：复杂慢性疾病的统一框架PMID:日期:2026-09-24Complex chronic conditions represent a growing health burden that is poorly understood and inadequately managed within current health systems. This review focuses on the potential of epigenetic DNA methylation to provide a pathway for better understanding of four closely related conditions: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), long COVID (LC), fibromyalgia (FM), and hypermobile Ehlers-Danlos syndrome (hEDS). These conditions have extensive overlapping symptoms, suggesting shared underlying pathophysiological mechanisms. Epigenetic regulation, particularly DNA methylation, provides a powerful framework for comparative and longitudinal studies across these clinically overlapping conditions. Here, we synthesise evidence from current DNA methylation studies in ME/CFS, LC, and FM, and consider how an integrated cross-condition approach could advance mechanistic insight, enable diagnostic stratification, and improve patient outcomes.
-
4. Beyond gene editing: the age of chromosome-scale genome engineering.
4. 超越基因编辑：染色体级别基因组工程时代PMID:日期:2026-09-19Genome engineering is moving from local sequence modification to manipulation of megabase-scale regions and whole chromosomes. This shift reflects the growing recognition that many biological functions and disease states are shaped by chromosome-scale features, including gene dosage across multiple loci, long-range regulation, chromatin context, replication timing, competition for limiting epigenetic factors, and three-dimensional genome organization. Here, we review the toolkit for chromosome-scale manipulation in higher eukaryotes, focusing on chromosome transfer, targeted chromosome elimination, and their integration into chromosome transplantation workflows. We discuss how these approaches, together with advances in large DNA assembly, synthetic biology, and genome-wide validation, are making chromosome-scale genome engineering an increasingly tractable experimental framework for understanding, building, and repairing genomes, while outlining the analytical requirements and current technical barriers that limit routine implementation.
-
5. African genomes are not a subset.
PMID:日期:2026-09-14Africa harbors more genetic variation than the rest of the world combined, but approximately 1% of genomes in major databases derive from individuals of African ancestry. This is not an equity problem; it is a scientific error that distorts drug dosing, degrades risk scores, and undermines precision medicine globally.
-
6. Mitotic chromosomes: from the chromosome scaffold model to condensins and physical forces.
PMID:日期:2026-09-14Mitotic chromosome organization and assembly remain fundamental questions in genetics. Since the chromosome scaffold model proposed in 1977 highlighted the role of nonhistone proteins in determining chromosome shape and size, key nonhistone proteins, including condensins and topoisomerase IIα (topoIIα), have been shown to play critical roles in organizing chromosome axes and chromatin loops. Emerging evidence from biochemistry, imaging, and genomics suggests that mitotic chromosome assembly is a dynamic process driven by the interplay of condensin-mediated looping, topoIIα-dependent entanglement/disentanglement, and multiple physical forces, including electrostatic nucleosome interactions, linker histone H1, free Mg, and depletion attraction. In this review, we discuss how these mechanisms contribute to chromosome assembly and propose that interphase chromatin domains function as dynamic building blocks of mitotic chromosomes.
-
7. Hologenomic interactions promote the higher-order evolvability of phenotypic complexity.
PMID:日期:2026-09-12Current models for evolvability and complexity generally focus on mutational and regulatory processes in the host genome alone, limiting their ability to explain the origin, inheritance, and dynamics of many phenotypes. We describe a framework treating multigenome interactions in the holobiont as a central process that impacts the genotype-phenotype map, expanding the dimensionality of mechanisms producing heritable variation, generating novel traits, and exploring adaptive trajectories. These mechanisms can promote both complex phenotypic innovation and evolutionary systems drift. Many evolutionary pathways and novelties cannot be fully understood from host data alone but require consideration of hologenomic targets of selection. We outline hypotheses and methods to quantify and evaluate their impacts as a fundamental macroevolutionary process.
-
8. Circular RNAs as central regulators of RNA stability.
PMID:日期:2026-09-07Circular RNAs (circRNAs) are a class of covalently closed, single-stranded RNAs generated predominantly through back-splicing of pre-mRNAs. Unlike their linear counterparts, circRNAs lack free 5' and 3' termini, rendering them intrinsically resistant to exoribonucleolytic degradation and conferring exceptional stability. In addition, accumulating evidence has revealed that circRNAs actively participate in regulating the stability of other RNA species. This review explores the current understanding of intrinsic molecular features dictating circRNA stability. Furthermore, we emphasize recent progress on how circRNAs crosstalk with and regulate the stability of other RNA species, including mRNAs and microRNAs, through various mechanisms. Ultimately, we provide an integrated perspective for understanding circRNA-centered regulation of RNA stability.
-
9. The study of evolvability in gene regulatory networks.
9. 基因调控网络中可演化性的研究PMID:日期:2026-09-07Evolvability refers to the capacity of biological systems to generate heritable and adaptive phenotypic variation. Theoretical work has identified general principles linking gene regulatory network (GRN) architecture, including modularity and connectivity, to the generation of such variation, whereas empirical studies have uncovered its molecular basis in specific systems. Despite these advances, the two approaches have largely developed in parallel, with direct tests of theoretically derived hypotheses remaining rare. Recent advances in single-cell omics techniques, GRN inference, and experimental perturbation methods now provide opportunities for a closer link between theory and empirical research on evolvability. Here, we synthesise the main advances on this topic and outline potentially fruitful avenues for investigating how network structure and developmental dynamics shape evolvability across systems.
-
10. Trends in large-scale human population cohorts.
10. 大规模人类人群队列的趋势PMID:日期:2026-09-01As a foundational infrastructure of biomedical research, large-scale human population cohorts have undergone rapid progress over the past decades. Driven by advances in high-throughput omics technologies, widespread adoption of electronic health records, and the emergence of artificial intelligence, these cohorts now integrate deep molecular profiling with longitudinal real-world data at an unprecedented scale. This transformation has shifted cohort research from primarily descriptive association studies toward mechanistic discovery, refined risk stratification, and genetically informed therapeutic development. In parallel, cohort initiatives are expanding globally beyond Western populations, accompanied by increasingly diverse funding, governance, and data-sharing models. Here, we review the major transformative trends shaping large-scale human population cohorts and discuss how these resources are redefining disease biology, translational research, and the future of precision medicine.