一种基于丝瓜结构纳米纤维膜的智能热响应缓释敷料，用于无烟艾灸治疗
A Smart Thermo-Responsive and Sustained-Release Dressing Based on Loofah-Structured Nanofibrous Membrane for Smokeless Moxibustion Therapy.
摘要(中文译文)
作为传统中医最具特色的治疗方法之一，艾灸疗法因其镇痛、抗炎和抗肿瘤作用而备受关注。然而，传统艾灸疗法缺乏便携性，燃烧过程中产生大量有害气体排放，且燃烧温度不可控，导致治疗效果不稳定。本研究开发了一种具有三层结构的智能热响应缓释敷料。在该设计中，电热碳纤维层负责产热，热致变色纳米纤维膜层实现温度可视化。核心功能层为通过静电纺丝制备的聚乳酸/中空碳纳米球/艾叶精油纳米纤维膜。借助其多级多孔结构及中空碳纳米球的微胶囊效应，该膜实现了高达164.32%的艾叶精油负载量，有效维持10天的缓释效果。该敷料表现出优异的热响应性和可重复使用性，即使在连续200次循环后仍能保持精确的温度控制。使用猪皮模型进行的实验表明，精油中的活性成分可渗透至角质层及去角质层组织中，且热疗显著增强了其经皮吸收。本研究为传统艾灸疗法的现代化提供了一种绿色、安全且便捷的解决方案。
Abstract
As one of the most distinctive therapeutic methods in traditional Chinese medicine, moxibustion therapy has garnered significant attention for its analgesic, anti-inflammatory, and anti-tumor effects. However, traditional moxibustion therapy lacks portability, generates substantial harmful gas emissions during combustion, and exhibits uncontrollable burning temperatures, which lead to unstable therapeutic outcomes. In this work, a smart thermo-responsive and sustained-release dressing with a three-layer structure is developed. Within this design, the electrothermal carbon fiber layer is responsible for heat generation, while the thermochromic nanofiber membrane layer enables temperature visualization. The core functional layer is a polylactic acid/hollow carbon nanosphere/mugwort essential oil nanofiber membrane fabricated via electrospinning. Leveraging its hierarchical porous structure and the microencapsulation effect of the hollow carbon nanospheres, the membrane achieves a high mugwort essential oil loading capacity of 164.32%, effectively maintaining sustained release over 10 days. The dressing exhibits excellent temperature responsiveness and reusability, maintaining accurate temperature control even after 200 consecutive cycles. Experiments using a porcine skin model demonstrated that the active components of the essential oil can penetrate into both the stratum corneum and stratum corneum-removed tissue, with thermotherapy significantly enhancing their transdermal absorption. This study provides a green, safe, and convenient solution for modernizing traditional moxibustion therapy.
如何引用
AMA
Jiaofan Sun, Yuanyuan Rao, Xin Zhang, Jing Liu, Shasha Feng, Yutang Kang, et al. A Smart Thermo-Responsive and Sustained-Release Dressing Based on Loofah-Structured Nanofibrous Membrane for Smokeless Moxibustion Therapy.. Small (Weinheim an der Bergstrasse, Germany). 2026; doi:10.1002/smll.74875.
APA
Jiaofan Sun, Yuanyuan Rao, Xin Zhang, Jing Liu, Shasha Feng, Yutang Kang, et al (2026). A Smart Thermo-Responsive and Sustained-Release Dressing Based on Loofah-Structured Nanofibrous Membrane for Smokeless Moxibustion Therapy.. Small (Weinheim an der Bergstrasse, Germany). https://doi.org/10.1002/smll.74875
GB/T 7714
Jiaofan Sun, Yuanyuan Rao, Xin Zhang, Jing Liu, Shasha Feng, Yutang Kang, et al. A Smart Thermo-Responsive and Sustained-Release Dressing Based on Loofah-Structured Nanofibrous Membrane for Smokeless Moxibustion Therapy.[J]. Small (Weinheim an der Bergstrasse, Germany), 2026 doi:10.1002/smll.74875.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出