连接齿状回和脾后颗粒皮质的回路调节雄性小鼠的骨折愈合
A circuit linking dentate gyrus and retrosplenial granular cortex regulates fracture healing in male mice.
摘要(中文译文)
创伤性脑损伤常加速骨折修复，但连接脑状态与骨愈合的神经环路仍不清楚。本研究表明，在雄性小鼠中，连接齿状回（DG）与压后颗粒皮质（RSGc）的海马-皮质环路调控骨损伤后的修复。骨骼损伤增加了两个区域中活动相关的标记。抑制DG或RSGc的兴奋性神经元，或抑制与DG-RSGc通路相关的神经元群体，可加速修复，而激活DG或RSGc兴奋性神经元则延迟愈合。RSGc激活抵消了DG抑制的促愈合效应，支持在所测试条件下DG-RSGc环路的依赖性。抑制性环路操作与循环神经肽Y升高、修复部位巨噬细胞IDO1诱导以及L-犬尿氨酸升高相关，后者促进成骨分化。药理学阻断与挽救实验支持一条NPY-IDO1-犬尿氨酸效应臂，将中枢环路状态与外周骨修复联系起来。
Abstract
Traumatic brain injury often accelerates fracture repair, but the neural circuits linking brain state to bone healing remain unclear. Here we show that, in male mice, a hippocampal-cortical circuit linking the dentate gyrus (DG) and the retrosplenial granular cortex (RSGc) regulates repair after bone injury. Skeletal injury increased activity-associated labeling in both regions. Inhibiting excitatory neurons in the DG or RSGc, or suppressing neuronal populations associated with the DG-RSGc pathway, accelerated repair, whereas activating DG or RSGc excitatory neurons delayed healing. RSGc activation counteracted the pro-healing effect of DG inhibition, supporting DG-RSGc circuit dependence under the tested conditions. Inhibitory circuit manipulations were associated with increased circulating neuropeptide Y, macrophage IDO1 induction at the repair site, and elevated L-kynurenine, which promoted osteogenic differentiation. Pharmacological blockade and rescue experiments support an NPY-IDO1-kynurenine effector arm linking central circuit state to peripheral bone repair.
如何引用
AMA
Wei Zhang, Wei Zhang, Yue Guo, Danni Chen, Xiaowen Jiang, Jingjing Zhang, et al. A circuit linking dentate gyrus and retrosplenial granular cortex regulates fracture healing in male mice.. Nature communications. 2026; doi:10.1038/s41467-026-75340-x.
APA
Wei Zhang, Wei Zhang, Yue Guo, Danni Chen, Xiaowen Jiang, Jingjing Zhang, et al (2026). A circuit linking dentate gyrus and retrosplenial granular cortex regulates fracture healing in male mice.. Nature communications. https://doi.org/10.1038/s41467-026-75340-x
GB/T 7714
Wei Zhang, Wei Zhang, Yue Guo, Danni Chen, Xiaowen Jiang, Jingjing Zhang, et al. A circuit linking dentate gyrus and retrosplenial granular cortex regulates fracture healing in male mice.[J]. Nature communications, 2026 doi:10.1038/s41467-026-75340-x.
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