尽管认识有限，但沙特阿拉伯公众对基因组编辑的接受是由治疗益处推动的
Public acceptance of genome editing in Saudi Arabia is driven by therapeutic benefit despite limited awareness.
摘要(中文译文)
基因组编辑技术正在改变精准医学和罕见病治疗领域；然而，其负责任的临床整合依赖于公众认知、伦理接受度以及对监管监督的信任。来自文化多样性人群的证据仍然有限，尤其是在基因组医学投资快速增长的地区。本研究开展了一项大规模全国性横断面调查，采用结构化自填式电子问卷，发放给18岁及以上的成年人。该工具评估了人口学特征、对基因组编辑的认知、感知获益与风险、伦理关切以及对基因组编辑应用的接受度。采用描述性统计、相关性分析和回归分析来检验与接受度相关的因素。共有1，712名参与者完成了调查。不到一半的受访者报告此前了解基因组编辑，表明基线熟悉度有限。对治疗性应用的支持率较高，尤其是当干预措施被表述为针对严重或危及生命的疾病的治疗时。积极态度和感知到的临床获益与接受度强烈相关，而感知风险则表现出适度的负相关。认知程度较高与伦理审慎性增加相关。对国家监管框架的信任显著增强了对基因治疗应用的信心。这些发现表明，沙特阿拉伯公众对治疗性基因组编辑持相对支持的态度，尤其是当其使用被置于适当的伦理和监管边界之内时。通过提供来自一个代表性不足且基因组学快速发展的地区的人群水平证据，本研究提供了可为文化响应性政策、公众参与以及基因组编辑技术的负责任临床转化提供参考的见解。
Abstract
Genome editing technologies are transforming precision medicine and rare disease therapeutics; however, their responsible clinical integration depends on public awareness, ethical acceptance, and trust in regulatory oversight. Evidence from culturally diverse populations remains limited, particularly in regions undergoing rapid investment in genomic medicine. A large nationwide cross-sectional survey was conducted using a structured, self-administered electronic questionnaire distributed to adults aged 18 years and older. The instrument assessed demographic characteristics, awareness of genome editing, perceived benefits and risks, ethical concerns, and acceptance of genome editing applications. Descriptive statistics, correlation analyses, and regression analyses were performed to examine factors associated with acceptance. A total of 1,712 participants completed the survey. Fewer than half of respondents reported prior awareness of genome editing, indicating limited baseline familiarity. Support for therapeutic applications was high, particularly when interventions were framed as treatments for serious or life-threatening conditions. Favourable attitudes and perceived clinical benefit were strongly associated with acceptance, while perceived risk demonstrated a modest negative association. Greater awareness was associated with increased ethical caution. Trust in national regulatory frameworks significantly strengthened confidence in gene therapy applications. These findings indicate a relatively supportive public perspective toward therapeutic genome editing in Saudi Arabia, particularly when its use is framed within appropriate ethical and regulatory boundaries. By providing population level evidence from an underrepresented region undergoing rapid genomic development, this study offers insights that may inform culturally responsive policy, public engagement, and responsible clinical translation of genome editing technologies.
如何引用
AMA
Hala Aldahshan, Tourkiah Alessa, Tahani O Alkahtani, Abeer Al-Hubaysh, Hamood AlSudais, Sana Saeed Alqarni, et al. Public acceptance of genome editing in Saudi Arabia is driven by therapeutic benefit despite limited awareness.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1827655.
APA
Hala Aldahshan, Tourkiah Alessa, Tahani O Alkahtani, Abeer Al-Hubaysh, Hamood AlSudais, Sana Saeed Alqarni, et al (2026). Public acceptance of genome editing in Saudi Arabia is driven by therapeutic benefit despite limited awareness.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1827655
GB/T 7714
Hala Aldahshan, Tourkiah Alessa, Tahani O Alkahtani, Abeer Al-Hubaysh, Hamood AlSudais, Sana Saeed Alqarni, et al. Public acceptance of genome editing in Saudi Arabia is driven by therapeutic benefit despite limited awareness.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1827655.
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