浆细胞性乳腺炎患者术后乳房功能和生活质量随访研究：1年纵向分析
Postoperative breast function and quality of life follow-up study in patients with plasma cell mastitis: a 1-year longitudinal analysis.
摘要(中文译文)
浆细胞性乳腺炎（PCM）是一种需要外科干预的慢性炎症性乳腺疾病，然而术后功能结局和生活质量尚缺乏充分描述。本研究评估了PCM手术治疗后乳房功能和健康相关生活质量的纵向变化。本回顾性纵向队列研究纳入142例经组织学确诊的PCM女性患者，均于2020年1月至2023年12月期间接受手术治疗。患者在基线、术后6个月和12个月接受评估。主要结局为乳房外观满意度（BREAST-Q）、疼痛强度（数字评定量表）和上肢功能（Quick-DASH）。次要结局为健康相关生活质量（SF-36）。采用线性混合模型分析随时间的变化，并进行Bonferroni校正的两两比较。平均年龄为35.67 ± 8.42岁。手术方式包括广泛局部切除（n = 71，50.0%）、局限切除（n = 32，22.5%）、区段乳房切除（n = 24，16.9%）和全乳切除（n = 15，10.6%）。BREAST-Q评分从基线的42.38 ± 12.56改善至12个月时的68.74 ± 14.23（P < 0.001）。疼痛评分从5.82 ± 2.14降至1.45 ± 1.23（P < 0.001）。Quick-DASH评分从38.67 ± 15.34改善至12.89 ± 8.76（P < 0.001）。SF-36躯体健康总评从38.45 ± 8.92升高至48.76 ± 7.34（P < 0.001）。所有结局在6个月时均显示显著改善，并在12个月时持续获益。12个月时达到最小临床重要差异的比例分别为：外观满意度89.4%、疼痛92.3%、功能85.2%。PCM的手术治疗可使乳房功能和生活质量获得显著且具有临床意义的改善，并持续至12个月。这些以患者为中心的结局数据支持手术干预的有效性，并可为术前咨询提供依据。
Abstract
Plasma cell mastitis (PCM) is a chronic inflammatory breast disease requiring surgical intervention, yet postoperative functional outcomes and quality of life remain poorly characterized. This study evaluated longitudinal changes in breast function and health-related quality of life following surgical treatment for PCM. This retrospective longitudinal cohort study included 142 women with histologically confirmed PCM who underwent surgical treatment between January 2020 and December 2023. Patients were assessed at baseline, 6 months, and 12 months postoperatively. Primary outcomes were breast appearance satisfaction (BREAST-Q), pain intensity (Numerical Rating Scale), and upper extremity function (Quick-DASH). Secondary outcome was health-related quality of life (SF-36). Linear mixed models analyzed changes over time with Bonferroni-adjusted pairwise comparisons. Mean age was 35.67 ± 8.42 years. Surgical procedures included wide local excision ( = 71, 50.0%), limited excision ( = 32, 22.5%), segmental mastectomy ( = 24, 16.9%), and total mastectomy ( = 15, 10.6%). BREAST-Q scores improved from 42.38 ± 12.56 at baseline to 68.74 ± 14.23 at 12 months ( < 0.001). Pain scores decreased from 5.82 ± 2.14 to 1.45 ± 1.23 ( < 0.001). Quick-DASH scores improved from 38.67 ± 15.34 to 12.89 ± 8.76 ( < 0.001). SF-36 Physical Component Summary increased from 38.45 ± 8.92 to 48.76 ± 7.34 ( < 0.001). All outcomes showed significant improvement at 6 months with continued gains at 12 months. The proportion achieving minimal clinically important differences at 12 months was 89.4% for appearance satisfaction, 92.3% for pain, and 85.2% for function. Surgical treatment for PCM results in significant and clinically meaningful improvements in breast function and quality of life sustained through 12 months. These patient-centered outcome data support surgical intervention effectiveness and inform preoperative counseling.
如何引用
AMA
Yining Ren, Wei Xing, Shurong Wang, Zhao Xu, Zixing Gong, Xuhui Qin. Postoperative breast function and quality of life follow-up study in patients with plasma cell mastitis: a 1-year longitudinal analysis.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1773980.
APA
Yining Ren, Wei Xing, Shurong Wang, Zhao Xu, Zixing Gong, Xuhui Qin (2026). Postoperative breast function and quality of life follow-up study in patients with plasma cell mastitis: a 1-year longitudinal analysis.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1773980
GB/T 7714
Yining Ren, Wei Xing, Shurong Wang, Zhao Xu, Zixing Gong, Xuhui Qin. Postoperative breast function and quality of life follow-up study in patients with plasma cell mastitis: a 1-year longitudinal analysis.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1773980.
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