早期活动预防机械通气患者ICU获得性衰弱：一项综合性综述
Early mobilization to prevent ICU-acquired weakness in mechanically ventilated patients: an integrative review.
摘要(中文译文)
重症监护病房获得性衰弱(ICU-AW)是危重症患者常见且严重的并发症，可导致机械通气撤机困难、住院时间延长及出院后功能状态受损。检索、评价并整合机械通气患者通过早期活动预防ICU-AW的最佳证据，为临床实践提供参考。遵循“5S”金字塔模型，自上而下系统检索国内外数据库，文献类型包括临床决策、指南、证据总结、最佳实践、专家共识、团体标准及系统评价。共纳入22项研究，包括1篇证据总结、3项指南、3项专家共识和15项系统评价。从这些文献中提取了27条证据，涵盖9个方面：多学科康复团队的建立、活动时机、活动评估、活动方式、运动频率与强度、活动前准备、活动监测、活动后观察及注意事项。本研究呈现了早期活动预防机械通气患者ICU-AW的关键证据，强调其在改善患者结局中的作用。系统评估、及时启动、个体化活动方案、渐进性运动方案、持续监测和多学科协作是有效且安全实施活动的关键。早期被动和主动活动可降低ICU-AW的发生率，缩短通气和ICU住院时间，并改善出院时的功能状态。http://ebn.nursing.fudan.edu.cn/registerResources，标识符ES20245841。
Abstract
Intensive Care Unit-acquired weakness (ICU-AW) is a prevalent and serious complication in critically ill patients, leading to difficulty in weaning from mechanical ventilation, prolonged hospital stays, and impaired functional status after discharge. To retrieve, evaluate, and integrate the best evidence for preventing ICU-AW through early mobilization in mechanically ventilated patients, and to provide references for clinical practice. Following the "5S" pyramid model, a top-down, systematic retrieval was conducted across domestic and international databases. The types of literature encompass clinical decisions, guidelines, evidence summaries, best practices, expert consensus, group standards, and systematic reviews. A total of 22 studies were included, comprising 1 evidence summary, 3 guidelines, 3 expert consensus statements, and 15 systematic reviews. 27 pieces of evidence were extracted from these articles, covering 9 areas: establishment of a multidisciplinary rehabilitation team, timing of mobilization, mobilization assessment, mobilization methods, frequency and intensity of exercise, pre-mobilization preparation, mobilization monitoring, post-mobilization observation, and precautions. This study presents key evidence on early mobilization to prevent ICU-AW in mechanically ventilated patients, highlighting its role in improving patient outcomes. Systematic assessment, timely initiation, individualized mobilization plans, progressive exercise protocols, continuous monitoring, and multidisciplinary collaboration are essential for the effective and safe implementation of mobilization. Early passive and active mobilization can reduce the incidence of ICU-AW, shorten ventilation and ICU stay, and improve functional status at discharge. http://ebn.nursing.fudan.edu.cn/registerResources, identifier ES20245841.
如何引用
AMA
Xinru Song, Ziwei He, Aijian Lei, Yanxin Ma, Yuding Hu, Xiao Li, et al. Early mobilization to prevent ICU-acquired weakness in mechanically ventilated patients: an integrative review.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1808281.
APA
Xinru Song, Ziwei He, Aijian Lei, Yanxin Ma, Yuding Hu, Xiao Li, et al (2026). Early mobilization to prevent ICU-acquired weakness in mechanically ventilated patients: an integrative review.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1808281
GB/T 7714
Xinru Song, Ziwei He, Aijian Lei, Yanxin Ma, Yuding Hu, Xiao Li, et al. Early mobilization to prevent ICU-acquired weakness in mechanically ventilated patients: an integrative review.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1808281.
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