杜比单抗在Netherton遗传性皮肤病皮肤微生物组变化中的作用：病例报告和文献综述
The role of dupilumab in skin microbiome shifts in the Netherton genodermatosis: a case report and review of literature.
摘要(中文译文)
皮肤菌群失调在炎症性皮肤病中起着至关重要的作用，尤其是在Netherton综合征（NS）等遗传性皮肤病中。本病例报告旨在探讨一名Netherton综合征患者在度普利尤单抗（dupilumab）治疗前及治疗期间皮肤微生物组的变化，以扩充目前该领域有限的证据。我们报告一例出生即诊断为NS的35岁女性患者，在接受度普利尤单抗治疗前表现为特应性皮炎（AD）、回状线状鱼鳞病和严重瘙痒。开始度普利尤单抗治疗后，在三个不同时间点从皮损部位采集皮肤拭子：基线时、连续治疗1个月后及连续治疗1年后。基线时，微生物组分析显示微生物多样性较低，以特定菌种为主。1年后，观察到微生物多样性显著增加，以特定菌种为主，且另一菌种数量增加。临床上，患者在这些微生物组变化的同时获得缓解。治疗后，皮肤微生物组显示微生物多样性增加，有益共生菌重新建立，更接近健康皮肤。本病例报告的发现强调了度普利尤单抗在恢复健康皮肤微生物组的同时改善遗传性皮肤病Netherton综合征症状和临床表现的作用。
Abstract
Skin dysbiosis plays a crucial role in inflammatory skin diseases, particularly in genodermatoses such as Netherton syndrome (NS). This case report aimed to investigate changes in the skin microbiome of a patient with Netherton syndrome before and during dupilumab therapy, with the goal of expanding the limited evidence currently available on this topic. We report the case of a 35-year-old woman diagnosed with NS at birth, who, prior to dupilumab therapy, presented with atopic dermatitis (AD), ichthyosis linearis circumflexa, and severe pruritus. Dupilumab therapy was initiated, and skin swabs were collected from lesional sites at three different time points: at baseline, after 1 month, and after 1 year of continuous dupilumab therapy. At baseline, a microbiome analysis revealed low microbial diversity with a predominance of and species. After 1 year, a significant increase in microbial diversity, with a predominance of species and an increase in species, was observed. Clinically, the patient experienced remission in parallel with these microbiome shifts. Post-treatment, the skin microbiome showed increased microbial diversity and re-establishment of beneficial commensals, more closely resembling healthy skin. The findings of this case report underscore the role of dupilumab in restoring a healthy skin microbiome along with symptomatological and clinical improvement in the genodermatosis Netherton syndrome.
如何引用
AMA
Elena Campione, Anna Simonelli, Enrico Salvatore Pistoia, Terenzio Cosio, Fabio Artosi, Laura Diluvio, et al. The role of dupilumab in skin microbiome shifts in the Netherton genodermatosis: a case report and review of literature.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1854027.
APA
Elena Campione, Anna Simonelli, Enrico Salvatore Pistoia, Terenzio Cosio, Fabio Artosi, Laura Diluvio, et al (2026). The role of dupilumab in skin microbiome shifts in the Netherton genodermatosis: a case report and review of literature.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1854027
GB/T 7714
Elena Campione, Anna Simonelli, Enrico Salvatore Pistoia, Terenzio Cosio, Fabio Artosi, Laura Diluvio, et al. The role of dupilumab in skin microbiome shifts in the Netherton genodermatosis: a case report and review of literature.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1854027.
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